5043-01-6

Usage

Uses

Used in Pharmaceutical Industry:
6-FLUORO-2-NAPHTHOIC ACID is used as an intermediate in the production of pharmaceuticals for its ability to contribute to the synthesis of complex organic molecules that can be utilized in the development of new drugs.
Used in Agrochemical Industry:
6-FLUORO-2-NAPHTHOIC ACID is used as an intermediate in the production of agrochemicals, where its chemical properties are leveraged to create compounds that can be used in the development of pesticides and other agricultural chemicals.
Used in Dye Industry:
6-FLUORO-2-NAPHTHOIC ACID is used as an intermediate in the production of dyes, where its unique structure and properties are employed to create a variety of colorants for different applications.
Used in Research and Development:
6-FLUORO-2-NAPHTHOIC ACID is used in research and development activities, particularly for the development of new drugs and materials, where its specific structural features and chemical properties are explored for innovative applications.

InChI:InChI=1/C11H7FO2/c12-10-4-3-7-5-9(11(13)14)2-1-8(7)6-10/h1-6H,(H,13,14)

Upstream product

• 5043-00-5 methyl 6-fluoro-4-methyl-2-naphthoate 
• 702640-90-2 6-fluoro-2-naphthoic acid ethyl ester 
• 7499-66-3 6-Bromonaphthalen-2-amine 
• 13790-83-5 6-fluoro-2-naphthonitrile 
• 33627-02-0 2-acetyl-6-fluoronaphthalene 
• 324-41-4 2-bromo-6-fluoronaphthalene 

Downstream Products

• 13916-91-1 6-fluoronaphthalen-2-amine 
• 944351-48-8 (6-fluoronaphthalen-2-yl)methanol 
• 1185653-38-6 N-(((3S,5S)-1-(2,2-diphenylethyl)-3-(2-(methoxy(methyl)amino)-2-oxoethyl)-2-oxo-1,4-diazepan-5-yl)methyl)-6-fluoro-2-naphthamide 
• 581-72-6 2-bromomethyl-6-fluoronaphthalene 
• 958328-31-9 6-Fluoro-naphthalene-2-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide 
• 324-41-4 2-bromo-6-fluoronaphthalene 
• 5043-00-5 methyl 6-fluoro-4-methyl-2-naphthoate 

Relevant academic research and scientific papers

SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS

Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3-C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.

Inhibitors of factor Xa

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Inhibitors of factor Xa

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Kinetics of Base-catalysed Iodination of Substituted Acetonaphthones

Kinetics of iodination of 6-substituted 2-acetonaphthones and of 4-substituted 1-acetonaphthones in 20percent pyridine-20percent methanol-60percent water (v/v) have been followed at three temperatures.The Hammett equation applies very well to these reactions.The rate constants for various heterocyclic base-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones in 60percent (v/v) methanol-water solvent have been correlated with pKa values of the conjugate acids of the heterocyclic bases via the Broensted equation giving β values of 0.88, 1.01 and 0.92 for acetophenone, 1-acetonaphthone and 2-acetonaphthone respectively.The influence of solvent on the rates of pyridine-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones has also been studied.