331949-29-2

Basic information

• Product Name: O2-benzyl O1-tert-butyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate
• CAS NO: 331949-29-2
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.37
• Mol File: 331949-29-2.mol

Chemical Properties

• Boiling Point: 441.4°C at 760 mmHg
• Flash Point: 220.8°C
• Density: 1.225g/cm³
• Vapor Pressure: 1.44E-08mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: O2-benzyl O1-tert-butyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: O2-benzyl O1-tert-butyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate(331949-29-2)
• EPA Substance Registry System: O2-benzyl O1-tert-butyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate(331949-29-2)

Safety Data

• Hazardous Substances Data: 331949-29-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 
• 94885-52-6 benzyl (L)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 331949-31-6 benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate 
• 571200-56-1 N-(Boc)-(2S,5S)-(5-(tert-butyl)carboxymethyl)proline benzyl ester 
• 412303-22-1 (2S,5R)-N-(tert-butoxycarbonyl)-5-tert-butylpropline benzyl ester 
• 863660-29-1 benzyl (2S)-N-tert-butoxycarbonyl-5-allylpyrrolidine-2-carboxylate 
• 372187-19-4 (2S,5R)-5-allylpyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 

Relevant articles and documents

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We describe the synthesis of benzyl (6S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6- carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic acid as starting material.

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Improved synthesis of (2S,5S)-5-tert-butylproline

(2S,5S)-N-Boc-5-tert-butylproline (1) was synthesized by an improved procedure featuring the conversion of (2S)-1-tert-butyldimethylsiloxy-2-N-(PhF)amino-5-oxo-6,6-dimethylheptane (16) into its corresponding imino alcohol followed by directed hydride deli