3335-22-6Relevant articles and documents
A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters Using Silver(I) Fluoride
Newton, Josiah,Driedger, Daniel,Nodwell, Matthew B.,Schaffer, Paul,Martin, Rainer E.,Britton, Robert,Friesen, Chadron M.
supporting information, p. 15993 - 15997 (2019/11/19)
Herein we report the mild and rapid fluorodesulfurization of thionoesters using only silver(I) fluoride. This reaction demonstrates excellent functional group tolerance and complements existing strategies for difluoroalkyl ether synthesis, which rely on t
Palladium-Nanoparticles-Catalyzed Oxidative Annulation of Benzamides with Alkynes for the Synthesis of Isoquinolones
Sharma, Nidhi,Saha, Rajib,Parveen, Naziya,Sekar, Govindasamy
supporting information, p. 1947 - 1958 (2017/06/09)
A novel method to synthesize isoquinolones via oxidative annulation of N-alkoxy benzamides and alkynes using binaphthyl-stabilized palladium nanoparticles (Pd-BNP) as catalyst has been developed. This methodology affords various isoquinolone derivatives in good to excellent yields with high regioselectivities in the presence of air as oxidant. N-Methoxybenzothioamide was also found to undergo oxidative annulation with alkyne successfully and provided a sulfur analogue of isoquinolones in moderate yields. The Pd-BNP catalyst was easily recovered and reused up to four times without any apparent agglomeration. (Figure presented.).
Laser flash photolysis studies of oxygen and sulfur atom transfer reactions from oxiranes and thiiranes to singlet carbenes
Pezacki, John Paul,Wood, Paul D.,Gadosy, Timothy A.,Lusztyk, Janusz,Warkentin, John
, p. 8681 - 8691 (2007/10/03)
Laser flash photolysis (UV-LFP) studies of benzylchlorodiazirine (1a), phenylchlorodiazirine (1b), phenylmethoxydiazirine (1c), 2,2-dimethoxy-5,5- dimethyl-Δ3-1,3,4-oxadiazoline (6a), 3,4-diaza-2,2-dimethoxy 1- oxa[4.3]spirooct-3-ene (6b), 5',5'-dimethoxyspiro[adamantane]-2,2 -[Δ3- 1,3,4-oxadiazoline] (6c), and diazofluorene (DAF) in the presence of oxiranes and thiiranes are reported. These compounds, upon irradiation, afford benzylchlorocarbene (2a), phenylchlorocarbene (2b), methoxyphenylcarbene (2c), dimethylcarbene (8a), cyclobutylidene (8b), adamantylidene (8c), and fluorenylidene (FL), respectively. Absolute rate constants for the transfer of oxygen and sulfur atoms to these carbenes have been determined in both acetonitrile and cyclohexane solvents. These carbenes abstract oxygen and sulfur atoms with bimolecular rate constants ranging from 104 to 1010 M- 1 s-1 at 22 °C. Ylides from attack of carbenes onto heteroatom donors were not observed for any of the heteroatom transfer reactions. It was found that the magnitudes of the rate constants for heteroatom transfer are dependent on the philicity of the carbene intermediate, and trends in the kinetic data suggest that oxygen and sulfur atom transfers occur by concerted mechanisms through ylide-like transition states. The reactions of dimethoxycarbene (14) with cyclohexene oxide and propylene sulfide have been studied by the thermolysis of 6a, in benzene, at 110 °C. It was found that dimethoxycarbene also abstracts oxygen and sulfur atoms, albeit in low yields. It is concluded that, for singlet carbenes, carbene electrophiiicity is important in these heteroatom transfer processes.
5,6-dihydro-4H-1,3-oxa(or thia)zine derivatives, their preparation and compositions containing them
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, (2008/06/13)
Compounds of formula: STR1 in which R1 denotes 2-indolyl, 2-thienyl, 3-furyl, naphthyl, phenyl, or phenyl substituted with one or two halogen atoms, with alkoxy, alkyl, nitro, acylamino, alkylthio, acyl, trifluoromethoxy, morpholino, piperidino
