3337-66-4Relevant articles and documents
Design and construction of endo -functionalized multiferrocenyl hexagons via coordination-driven self-assembly and their electrochemistry
Chen, Li-Jun,Li, Quan-Jie,He, Jiuming,Tan, Hongwei,Abliz, Zeper,Yang, Hai-Bo
, p. 1148 - 1153 (2012)
The construction of a new family of endo-functionalized multiferrocenyl hexagons with various sizes via coordination-driven self-assembly is described. The structures of these novel metallacycles, containing several ferrocenyl moieties at their interior s
Bifunctional pillararene derivative ligand, metal organic cage and preparation method
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Paragraph 0033; 0038; 0040, (2020/07/28)
The invention discloses a bifunctional pillararene derivative ligand, a metal organic cage and a preparation method. The pillararene derivative ligand has a structure shown as a formula (I); a pillararene and tetraphenyl ethylene with large steric hindran
Preparation method of amiodarone hydrochloride (by machine translation)
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Paragraph 0077-0079, (2019/08/12)
The invention provides a preparation method, and relates to the technical field of drug synthesis, in particular to a preparation method of amiodarone hydrochloride. The invention uses methyl hydroxybenzoate as a main raw material, and sequentially undergoes a substitution reaction, etherification reaction, hydrolysis reaction, chloro reaction, a reaction, amination reaction and acidification, and the amiodarone hydrochloride. The preparation method provided by the invention does not need the process, reduces the use, reduces the environmental pollution, greatly reduces the environmental pollution and shortens the synthesis route while chlorination of 3, 5 - diiod -4 - (2 -hydroxyethoxy) - benzoic acid by using the thionyl chloride is reduced, and the synthetic route. The preparation method provided by the invention is simple in process, low in cost, small in pollution and high in yield. (by machine translation)
Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant
Sdahl, Mark,Conrad, Jürgen,Braunberger, Christina,Beifuss, Uwe
, p. 19549 - 19559 (2019/07/05)
The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.
Method for synthesizing amiodarone impurity G and application of amiodarone impurity G
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Paragraph 0054-0058, (2017/07/07)
The invention provides a method for synthesizing an amiodarone impurity G and application of the amiodarone impurity G, and relates to the technical field of chemical synthesis. According to the method for synthesizing the amiodarone impurity G, the amiod
Xanthine oxidase inhibitor and application thereof
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Paragraph 0097; 0098, (2017/08/26)
The invention discloses a xanthine oxidase inhibitor and application thereof. The xanthine oxidase inhibitor is a compound shown as a general formula (I) and is a pharmaceutically acceptable salt. The xanthine oxidase inhibitor, which is the compound and
IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF
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Paragraph 00133, (2016/12/22)
The present disclosure provides new procedures and intermediates for the preparation of Sofosbuvir.
Generation of 3-borylbenzynes, their regioselective Diels-Alder reactions, and theoretical analysis
Takagi, Akira,Ikawa, Takashi,Kurita, Yurio,Saito, Kozumo,Azechi, Kenji,Egi, Masahiro,Itoh, Yuji,Tokiwa, Hiroaki,Kita, Yasuyuki,Akai, Shuji
supporting information, p. 4338 - 4352 (2013/06/04)
3-Borylbenzynes were generated in situ from 6-boryl-2-iodophenyl trifluoromethanesulfonates using i-PrMgCl·LiCl and applied to Diels-Alder reactions with substituted furans and pyrroles. The reactions allowed good functional group compatibility and produced the cycloadducts in high yields with high distal selectivities. Effective conversion of the boryl group of the products was achieved. A series of these reactions provides a new method for producing multifunctionalized benzo-fused aromatic compounds. Additionally, the regioselectivities of these Diels-Alder reactions were theoretically analyzed by DFT calculations to find that the reactions were mainly controlled by the electrostatic effect and aryne distortion caused by the boryl group.
Regiocomplementary cycloaddition reactions of boryl- and silylbenzynes with 1,3-dipoles: Selective synthesis of benzo-fused azole derivatives
Ikawa, Takashi,Takagi, Akira,Goto, Masahiko,Aoyama, Yuya,Ishikawa, Yoshinobu,Itoh, Yuji,Fujii, Satoshi,Tokiwa, Hiroaki,Akai, Shuji
, p. 2965 - 2983 (2013/06/26)
Benzo-fused nitrogen-containing heterocycles are abundant in biologically active compounds. One of the most important methods for preparing such heterocycles is the (3 + 2) cycloaddition reaction of benzynes with 1,3-dipolar compounds. However, the reacti
Preparation and regioselective Diels-Alder reactions of borylbenzynes: Synthesis of functionalized arylboronates
Ikawa, Takashi,Takagi, Akira,Kurita, Yurio,Saito, Kozumo,Azechi, Kenji,Egi, Masahiro,Kakiguchi, Keisuke,Kita, Yasuyuki,Akai, Shuji
supporting information; experimental part, p. 5563 - 5566 (2010/09/05)
(Figure Presented) B+ [4+2]: 3-Borylbenzynes undergo Diels-Alder reactions with substituted furans and pyrroles to give highly functionalized arylboronic acid derivatives with either good or exclusive regioselectivities (see picture). The effect of the boryl group on the regioselectivity arises from electronic rather than steric effects.