618-76-8

Basic information

• Product Name: 3,5-DIIODO-4-HYDROXYBENZOIC ACID
• Synonyms: NSC 1497;RARECHEM AL BO 0345;3,5-diiodo-4-hydroxy-benzoicaci;4-hydroxy-3,5-diiodo-benzoicaci;ioxynilacid;mandb10903;3,5-DIIODO-4-HYDROXYBENZOIC ACID;4-HYDROXY-3,5-DIIODOBENZOIC ACID
• CAS NO: 618-76-8
• Molecular Formula: C₇H₄I₂O₃
• Molecular Weight: 389.91
• EINECS: 210-562-0
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 618-76-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 275°C (dec.)
• Boiling Point: 346.4°C at 760 mmHg
• Flash Point: 163.3°C
• Appearance: /
• Density: 2.4343 (estimate)
• Vapor Pressure: 2.19E-05mmHg at 25°C
• Refractive Index: 1.784
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Dichloromethane, Ethyl Acetate
• PKA: 3.87±0.10(Predicted)
• Sensitive: Light Sensitive
• BRN: 2212145
• CAS DataBase Reference: 3,5-DIIODO-4-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIIODO-4-HYDROXYBENZOIC ACID(618-76-8)
• EPA Substance Registry System: 3,5-DIIODO-4-HYDROXYBENZOIC ACID(618-76-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• RTECS: DG8597500
• TSCA: Yes
• Hazardous Substances Data: 618-76-8(Hazardous Substances Data)

Usage

Chemical Properties

3,5-DIIODO-4-HYDROXYBENZOIC ACID is Off-White Solid

Uses

3,5-DIIODO-4-HYDROXYBENZOIC ACID is used in the preparation of Thyroid hormone analogues.

InChI:InChI=1/C7H4I2O3/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,10H,(H,11,12)

Upstream product

• 1948-40-9 4-hydroxy-3,5-diiodobenzaldehyde 
• 37470-46-5 4-hydroxy-3-iodobenzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 7664-41-7 ammonia 
• 7553-56-2 iodine 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 190071-24-0 4-acetylamino-3-iodo-benzoic acid 
• 29289-16-5 N-(2-iodo-4-methylphenyl)acetamide 
• 29289-13-2 2-iodo-4-methylaniline 
• 7647-01-0 hydrogenchloride 
• 2122-61-4 4-amino-3,5-diiodobenzoic acid 

Downstream Products

• 54073-94-8 4-hydroxy-3,5-diiodo-benzoic acid ethyl ester 
• 842-35-3 3,5-diiodo-4-benzyloxybenzoic acid 
• 59100-51-5 4-Hexadecyloxy-3,5-diiodo-benzoic acid 
• 340313-47-5 4-(3-bromo-benzyloxy)-3,5-diiodo-benzoic acid 3-bromo-benzyl ester 
• 1228685-61-7 C₁₄H₁₈I₂O₆ 
• 51-38-7 butyl 3,5-di-iodo-4-hydroxybenzoate 
• 1620001-71-9 C₁₉H₂₈I₂O₃ 

Relevant articles and documents

Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogenous conditions, we were keen on developing iodination protocol of arenes that can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activates N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tunes sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chemicals, API, and natural products.

Improving the reactivity of phenylacetylene macrocycles toward topochemical polymerization by side chains modification

The synthesis and self-assembly of two new phenylacetylene macrocycle (PAM) organogelators were performed. Polar 2-hydroxyethoxy side chains were incorporated in the inner part of the macrocycles to modify the assembly mode in the gel state. With this modification, it was possible to increase the reactivity of the macrocycles in the xerogel state to form polydiacetylenes (PDAs), leading to a significant enhancement of the polymerization yields. The organogels and the PDAs were characterized using Raman spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM).

PROCESS FOR PRODUCTION OF PHENOL DERIVATIVES SUBSTITUTED WITH IODINE AT ORTHO POSITION

A process in which a phenol derivative is iodinated to produce a 2-iodophenol or 2,6-diiodophenol derivative substituted with iodine at an ortho position thereof is provided, which does not require any step of recovery of iodine but can produce it at low cost, in high yield and with high quality. A phenol derivative is mixed with a pyridine and hydrogen peroxide or iodic acid as an oxidizing agent, and reacted with molecular iodine. As a result, iodination can be performed very efficiently with iodine in an amount close to the theoretical amount relative to the phenol derivative, and the 2-iodophenol or 2,6-diiodophenol derivative can be obtained in high yield and with high quality.