- The syntheses of 4,4'-(1,n-dioxaalkane)-bisbenzaldehydes and 4,4'-(1,n- dioxaalkane)-bis(α-methoxy phenylacetic acids)
-
The syntheses of 4,4'-(1,n-dioxaalkane)-bis(α-methoxyphenylacetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4'-(1,n-dioxaalkane)-bisbenz
- Jiang, Jianjun,Compere Jr., Edward L.
-
-
Read Online
- Synthesis, anti-Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine
-
Three new bisguanylhydrazones analogous to pentamidine were synthesized, fully characterized and tested as anti-Trypanosoma cruzi candidates. Contrary to literature reports, that bicationic compounds are more active than monocationic compounds against Try
- Borges, Márcia Narcizo,Messeder, Jorge Cardoso,Figueroa-Villar, José Daniel
-
-
Read Online
- Synthesis, Molecular Docking Studies, and Anticonvulsant Evaluation of Novel bis-Phenylhydrazones against Chemically induced Seizures in Mice
-
A series of novel bis-phenylhydrazones were synthesized by the condensation of dialdehydes with phenylhydrazine to evaluate them for their anticonvulsant activity. Efficacy of newly synthesized compounds against pentylenetetrazole (PTZ)-induced, strychnin
- Siddiqi, Humaira Masood,Tabasum, Aneela,Qasim, Sumera,Akhtar, Muhammad Shoaib,Kalsoom, Saima,Ansari, Farzana Latif
-
-
Read Online
- Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst
-
Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) which are linked to aliphatic or aromatic spacers via ether or ester linkages were performed in good to excellent yields by the reaction of 5,5-dimethyl-1,3-cyclohexanedione with the appropriate bis-aldehydes using p-TSA as an organic acid solid catalyst. The reaction of the bis-aldehydes with barbituric acid or 1,3-dimethylbarbituric acid instead of 5,5-dimethyl-1,3-cyclohexanedione afforded the corresponding Knoevenagel condensation adducts in good yield.
- Darweesh, Ahmed F.,Salama, Soad K.,Abdelhamid, Ismail A.,Elwahy, Ahmed H. M.
-
-
Read Online
- Synthesis, characterization and anticancer activity of dinuclear ruthenium(II) complexes linked by an alkyl chain
-
A series of 1,10-phenanthroline-based dinucleating bridging ligands BL1-3 and their dinuclear ruthenium Ru(ii) complexes [(bpy)2Ru(BL1-3)Ru(bpy)2](PF6)4 (bpy = 2,2′-bipyridine; PF6/su
- Zhang, Yan,Lai, Lu,Cai, Ping,Cheng, Gong-Zhen,Xu, Xi-Ming,Liu, Yi
-
-
Read Online
- A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate
-
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent
- Hirsch, Anna K. H.,Imberty, Anne,Kinsinger, Thorsten,Kuhaudomlarp, Sakonwan,Lepsik, Martin,Minervini, Saverio,Titz, Alexander,Yousaf, Sultaan,Zahorska, Eva
-
-
Read Online
- Synthesis, antitumor activity, enzyme assay, DNA binding and molecular docking of Bis-Schiff bases of pyrazoles
-
A novel series of Bis-Schiff bases of pyrazoles 9–24 were synthesized by the direct condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly synthesized Bis-Schiff bases of pyrazoles 9–24 were characterized and confirmed by analyt
- Morsy, Nesrin M.,Hassan, Ashraf S.,Hafez, Taghrid S.,Mahran, Mohamed R. H.,Sadawe, Inass A.,Gbaj, Abdul M.
-
-
- Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene
-
In this work, the new trinuclear manganese catalyst defined as Fe3O4@NFC@NNSM-Mn(iii) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP analysis. There have been reports of the use of magnetic catalysts for the synthesis of xanthine derivatives. The critical potential interest in the present method include short reaction time, high yields, recyclability of the catalyst, easy workup, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. Also, the synthesized catalyst was used as a recyclable trinuclear catalyst in alcohol oxidation reactions at 40 °C. The magnetic catalyst activity of Fe3O4@NFC@NNSM-Mn(iii) could be attributed to the synergistic effects of the catalyst Fe3O4@NFC@NNS-Mn(iii) with melamine. Employing a sustainable and safe low temperature, using an eco-friendly solvent, no need to use any additive, and long-term stability and magnetic recyclability of the catalyst for at least six successive runs are the advantages of the current protocol towards green chemistry. This protocol is a benign, environmentally friendly method for heterocycle synthesis. This journal is
- Ghamari Kargar, Pouya,Bagherzade, Ghodsieh,Eshghi, Hossein
-
p. 4339 - 4355
(2021/02/03)
-
- BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA
-
The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.
- -
-
Page/Page column 31-32; 42
(2021/05/15)
-
- Structural chemistry and anti-inflammatory activity of flexible/restricted phenyl dimers
-
Three phenyl dimer compounds, namely 3,3′-Diformyldiphenoxyethane (C16H14O4) (1), 1-(4-[2-(4-Acetyl-phenoxy)-ethoxy]-phenyl)-ethanone (C17H16N2O3) (2), 1-{4-[2-(4-Acetyl-phenoxymethyl)-benzyloxy]-phenyl}-ethanone (C24H22O4) (3), were obtained and fully characterized, including their crystal structure determinations. The structural properties of two compounds 4, 4′-(ethylenedioxy)dibenzaldehyde) (C16H14O4) (Tewari et al. Acta Cryst. E63:o1930, 2007) [1] (4) and 4-(2-Phenoxy-ethoxy)-benzaldehyde (C15H14O3) (Valgera et al. CCDC 710835, 2016) [2] (5) are discussed with the role of the substituent in crystal packing. In vivo, anti-inflammatory activities of all compounds were studied on Wistar strain albino rats. All the compounds exhibited anti-inflammatory activity except 5. Compounds 1, 2, 4 have shown moderate-to-intermediate effects on inhibitory properties. Compound (3) with restricted rotation in the compound-like SC-558 drug was shown to possess good inhibitory properties at 180?min. In silico analysis was performed and compared with experimental in vivo results.
- Singh, Ved Prakash,Dowarah, Jayanta,Tewari, Ashish Kumar,Geiger, David K.
-
p. 1289 - 1303
(2020/01/22)
-
- Novel 2-cyanoacrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents
-
Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate as well as its corresponding bis-derivatives, 5–10, with aliphatic linkers were synthesized, fully characterized, and tested as novel anticancer agents. The targeted compounds, 5–10, wer
- Sroor, Farid M.,Aboelenin, Mohamad M.,Mahrous, Karima F.,Mahmoud, Khaled,Elwahy, Ahmed H. M.,Abdelhamid, Ismail A.
-
-
- Biferrocenyl Schiff bases as efficient corrosion inhibitors for an aluminium alloy in HCl solution: A combined experimental and theoretical study
-
The corrosion inhibitive capabilities of some ferrocene-based Schiff bases on aluminium alloy AA2219-T6 in acidic medium were investigated using Tafel polarization, electrochemical impedance spectroscopy (EIS), weight loss measurement, FT-IR spectroscopy and scanning electron microscopic (SEM) techniques. The influence of molecular configuration on the corrosion inhibition behavior has been explored by quantum chemical calculation. Ferrocenyl Schiff bases 4,4′-((((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcua), 4,4′-((((ethane-1,2-diylbis(oxy))bis(2-methoxy-1,4-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcub) and 4,4′-((((ethane-1,2-diylbis(oxy))bis(2-ethoxy-1,4-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcuc) have been synthesized and characterized by FT-IR, 1H and 13C NMR spectroscopic studies. These compounds showed a substantial corrosion inhibition against aluminium alloy in 0.1 M of HCl at 298 K. Fcub and Fcuc showed better anticorrosion efficiency as compared with Fcua due to the electron donating methoxy and ethoxy group substitutions, respectively. Polarization curves also indicated that the studied biferrocenyl Schiff bases were mixed type anticorrosive materials. The inhibition of the aluminium alloy surface by biferrocenyl Schiff bases was evidenced through scanning electron microscopy (SEM) studies. Semi-empirical quantum mechanical studies revealed a correlation between corrosion inhibition efficiency and structural functionalities.
- Adeel Asghar, Muhammad,Akhter, Zareen,Butt, Tehmeena Maryum,Hussain, Rizwan,Janjua, Naveed Kausar,Kanwal, Sehrish,Liaqat, Faroha,Nazir, Uzma,Sani, Asma,Shah, Faiz Ullah
-
p. 7585 - 7599
(2020/03/10)
-
- Design, synthesis,: In silico docking studies and biological evaluation of novel quinoxaline-hydrazide hydrazone-1,2,3-triazole hybrids as α-glucosidase inhibitors and antioxidants
-
A new series of quinoxaline-hydrazidehydrazone-1,2,3-triazole hybrids, 14a-j, 15a-j and 16a-e, was designed, synthesized and screened for in vitro α-glucosidase and antioxidant activities. For the synthesis of the target compounds, quinoxaline hydrazides were condensed with benzaldehyde triazoles in the presence of AcOH (cat) in ethanol. The key step in the preparation of compounds 8a-j was the Cu(i)-catalyzed [3+2] cycloaddition reaction (CuAAC) with appropriate alkynes (6, 7) and azides, and 13a-j were prepared from simple aldehydes utilizing the same click reaction as the final step. Quinoxaline hydrazides (3, 3a) were synthesized from o-phenylenediamine and pyruvic acid via three-step reactions comprising cyclization, alkylation and hydrazidation. Among these hybrids, 14a (IC50 = 21.92 μg mL-1), 14b (IC50 = 22.32 μg mL-1), 14c (IC50 = 23.58 μg mL-1) and 15a (IC50 = 24.50 μg mL-1) showed good α-glucosidase inhibition compared with the standard acarbose (IC50 = 22.32 μg mL-1). Further, the scavenging abilities of the synthesized compounds as antioxidants were studied using the DPPH, H2O2, and NO methods; as per the obtained results, compounds 14a, 14b, 14c and 15a displayed good antioxidant activity. Docking studies of the active compounds and acarbose as a standard with α-glucosidase (PDB ID: 2ZEO) were performed to determine the molecular interactions between the inhibitors and the active site of the enzyme. Better binding energies of the active compounds than of the standard acarbose were observed. Therefore, our new hybrid molecules may be useful for further optimization in developing new lead molecules with both α-glucosidase inhibition and antioxidant activities.
- Settypalli, Triloknadh,Chunduri, Venkata Rao,Maddineni, Aruna Kumari,Begari, Nagaraju,Allagadda, Rajasekhar,Kotha, Peddanna,Chippada, Appa Rao
-
p. 15435 - 15452
(2019/10/08)
-
- Synthesis and spectral study of some new (tetrazole, thiazolidin-4-one) compounds derived from amino drugs and evaluation their antibacterial activities
-
Two new series of substituted tetrazole and thiazolidin-4-one derivatives were synthesized by a three-step procedure, involving the reaction of p-hydroxybenzaldehyde with dichloroethane to result compound 1. The reaction of compound 1 with various amino d
- Mahdi, Inas S.,Yousif, Selvana Adwar,Khammas, Sameaa J.
-
p. 409 - 417
(2020/01/03)
-
- Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors
-
Known PTP1B inhibitors with bis-anionic moieties exhibit potent inhibitory activity, good selectivity, however, they are incapable of penetrating cellular membranes. Based upon our finding of a new pharmacophoric group in inhibition of PTP1B and the struc
- Yang, Fengzhi,Xie, Fangzhou,Zhang, Ying,Xia, Yu,Liu, Wenlu,Jiang, Faqin,Lam, Celine,Qiao, Yixue,Xie, Dongsheng,Li, Jianqi,Fu, Lei
-
supporting information
p. 2166 - 2170
(2017/04/27)
-
- Novel PTP1B enzyme inhibitor, preparation method and applications thereof
-
The present invention provides a novel PTP1B enzyme inhibitor, a preparation method and applications thereof, and particularly discloses a class of bis 2-substituted ethylene sulfonate compounds and a preparation method thereof, and uses of the bis 2-substituted ethylene sulfonate compounds as the PTP1B enzyme activity inhibitor. According to the present invention, the prepared novel compound has good PTP1B enzyme activity inhibition effect, and has the application value in preparation of drugs for treatment and prevention of diabetes and obesity.
- -
-
Paragraph 0110-0111
(2017/08/31)
-
- Synthesis and mesomorphic properties of new methylene-linked linear symmetrical liquid crystal dimers
-
A series of methylene-linked symmetrical liquid crystal dimers were synthesized. Their structures were confirmed by physicochemical techniques. Differential scanning calorimetry and polarizing optical microscopy verified the liquid crystal behaviors and t
- Al-Hamdani, Uhood J.,Al-Ibrahim, Aiman G.,Abbo, Hanna S.,Titinchi, Salam J.J.
-
-
- One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity
-
Abstract A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were char
- Linga Goud,Ramesh,Ashok,Prabhakar Reddy
-
p. 673 - 678
(2015/05/05)
-
- Synthesis of N-aryloxyalkylanabasine derivatives
-
N-Aryloxyalkylanabasine derivatives were prepared via the reaction of anabasine hydrochloride with various aryloxyhaloalkanes in the presence of potash in DMF. The reaction occurred with retention of the chiral center C-(2) of the piperidine group. Side products of bis(aryloxy)ethanes were characterized.
- Slyn'Ko,Tatarova,Shakirov,Shul'Ts
-
p. 294 - 301
(2013/07/26)
-
- New bispyrazoline derivatives built around aliphatic chains: Synthesis, characterization and antimicrobial studies
-
The bispyrazolines 3a-3h built around the alkyl chains of varying lengths have been synthesized from the cyclization reactions of bischalcones with phenyl hydrazine. The bischalcones 2a-2h were obtained from the Claisen-Schmidt reactions of acetophenone w
- Yusuf, Mohamad,Jain, Payal
-
p. 117 - 127
(2013/05/08)
-
- Biological evaluation of bisbenzaldehydes against four Mycobacterium species
-
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
- Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
-
p. 731 - 738
(2013/07/25)
-
- Chelate cooperativity and spacer length effects on the assembly thermodynamics and kinetics of divalent pseudorotaxanes
-
Homo- and heterodivalent crown-ammonium pseudorotaxanes with different spacers connecting the two axle ammonium binding sites have been synthesized and characterized by NMR spectroscopy and ESI mass spectrometry. The homodivalent pseudorotaxanes are investigated with respect to the thermodynamics of divalent binding and to chelate cooperativity. The shortest spacer exhibits a chelate cooperativity much stronger than that of the longer spacers. On the basis of crystal structure, this can be explained by a noninnocent spacer, which contributes to the binding strength in addition to the two binding sites. Already very subtle changes in the spacer length, i.e., the introduction of an additional methylene group, cause substantial changes in the magnitude of cooperative binding as expressed in the large differences in effective molarity. With a similar series of heterodivalent pseudorotaxanes, the spacer effects on the barrier for the intramolecular threading step has been examined with the result that the shortest spacer causes a strained transition structure and thus the second binding event occurs slower than that of the longer spacers. The activation enthalpies and entropies show clear trends. While the longer spacers reduce the enthalpic strain that is present in the transition state for the shortest member of the series, the longer spacers become entropically slightly more unfavorable because of conformational fixation of the spacer chain during the second binding event. These results clearly show the noninnocent spacers to complicate the analysis of multivalent binding. An approximate description which considers the binding sites to be connected just by a flexible chain turns out to be more a rough approximation than a good model. The second conclusion from the results presented here is that multivalency is expressed in both the thermodynamics and the kinetics in different ways. A spacer optimized for strong binding is suboptimal for fast pseudorotaxane formation.
- Jiang, Wei,Nowosinski, Karol,Loew, Nora L.,Dzyuba, Egor V.,Klautzsch, Fabian,Schaefer, Andreas,Huuskonen, Juhani,Rissanen, Kari,Schalley, Christoph A.
-
supporting information; experimental part
p. 1860 - 1868
(2012/03/11)
-
- Synthesis of photoactive bichromophoric dyads containing 2-styrylquinoline and 2-naphthol moieties
-
A three-step approach to the synthesis of bichromophoric dyads of the general formula SQ - (CH2)n - Np (SQ is the 2-(4-oxystyryl)quinoline moiety, Np is the 3-oxy-2-naphthol moiety, n = 2, 4, 5) was developed from available reagents.
- Gavrishova,Li,Sadykova,Budyka
-
experimental part
p. 1495 - 1499
(2012/07/13)
-
- Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents
-
A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium
- Mayence, Annie,Vanden Eynde, Jean Jacques,Kaiser, Marcel,Brun, Reto,Yarlett, Nigel,Huang, Tien L.
-
experimental part
p. 7493 - 7500
(2012/01/03)
-
- The interesting DNA-binding properties of three novel dinuclear Ru(II) complexes with varied lengths of flexible bridges
-
Three binuclear Ru(II) complexes with two [Ru(bpy)2(pip)] 2+-based subunits {where bpy = 2,2′-bipyridine and pip = 2-phenylimidazo[4,5-f][1,10]phenanthroline} being linked by varied lengths of flexible bridges, were synthesized and characterized by 1H NMR, elemental analysis, UV-visible (UV-vis) and photoluminescence spectroscopy. The structures of the three complexes were optimized by density functional theory calculations. The interaction of the complexes with calf thymus DNA was investigated by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN)6]4-, DNA competitive binding with ethidium bromide, DNA melting experiments, and viscosity measurements. The experimental results indicated that the three complexes bound to the DNA most probably in a threading intercalation binding mode with high DNA binding constant values three orders of magnitude greater than the DNA binding constant value reported for proven DNA intercalator, mononuclear counterpart [Ru(bpy)2(p-mopip)]2+ {p-mopip = 2-(4-methoxylphenyl) imidazo[4,5-f][1,10]phenanthroline}.
- Ju, Chuan-Chuan,Zhang, An-Guo,Yuan, Chui-Li,Zhao, Xiao-Long,Wang, Ke-Zhi
-
p. 435 - 443
(2012/02/14)
-
- Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: Synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells
-
Much effort has been spent on searching for better P-glycoprotein- (P-gp-) based multidrug resistance (MDR) modulators. Our approach was to target the binding sites of P-gp using dimers of dietary flavonoids. A series of apigenin-based flavonoid dimers, linked by poly(ethylene glycol) chains of various lengths, have been synthesized. These flavonoid dimers modulate drug chemosensitivity and retention in breast and leukemic MDR cells with the optimal number of ethylene glycol units equal to 2-4. Compound 9d bearing four ethylene glycol units increased drug accumulation in drug-resistant cells and enhanced cytotoxicity of paclitaxel, doxorubicin, daunomycin, vincristine, and vinblastine in drug-resistant breast cancer and leukemia cells in vitro, resulting in reduction of IC50 by 5-50 times. This compound also stimulated P-gp's ATPase activity by 3.3-fold. Its modulating activity was presumably by binding to the substrate binding sites of P-gp and disrupting drug efflux.
- Chan, Kin-Fai,Zhao, Yunzhe,Burkett, Brendan A.,Wong, Iris L. K.,Chow, Larry M. C.,Chan, Tak Hang
-
p. 6742 - 6759
(2007/10/03)
-
- DNA sequence-specific ligands: XII. Synthesis and cytological studies of dimeric hoechst 33258 molecules
-
We synthesized dimeric Hoechst dye molecules composed of two moieties of Hoechst 33258 fluorescent dye with the phenolic hydroxy groups tethered via pentamethylene, heptamethylene, or triethylene oxide linkers. A characteristic pattern of differential staining of chromosome preparations from human HL60 premonocytic leukemia cells was observed for all the three fluorescent dyes. The most contrasting pattern was obtained for the bisHoechst analogue with the heptamethylene linker; its quality was comparable with the picture obtained in the case of chromosome staining with 4′,6-diamidino-2-phenylindole. The ability to penetrate into live human fibroblasts was studied for the three bisHoechst compounds. The fluorescence intensity of nuclei of live and fixed cells stained with the penta- and heptamethylene-linked bisHoechst analogues was found to differ only slightly, whereas the fluorescence of the nuclei of live cells stained with triethylene oxide-linked bisHoechst was considerably weaker than that of the fixed cells. The bisHoechst molecules are new promising fluorescent dyes that can both differentially stain chromosome preparations and penetrate through cell and nuclear membranes and effectively stain cell nuclei.
- Gromyko,Popov,Mosoleva,Streltsov,Grokhovsky,Oleinikov,Zhuze
-
p. 344 - 351
(2008/02/03)
-
- Synthesis and thermal properties of twin dimers containing cyanostilbene groups as a mesogenic group
-
Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cycmostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the est
- Aoki,Mihara,Koide
-
-
- A facile and selective synthetic method for the preparation of aromatic dialdehydes from diesters via the amine-modified SMEAH reduction system
-
A new reduction system employing N-methylpiperazine-modified sodium bis(2-methoxyethoxy)aluminum hydride (NMP-SMEAH) for the conversion of aromatic diesters to dialdehydes is described. The method is plain and efficient, and can be carried out under mild and operationally simple conditions applicable for large scale productions.
- Hagiya, Kazutake,Mitsui, Sunao,Taguchi, Hiroaki
-
p. 823 - 828
(2007/10/03)
-
- Synthesis and characterisation of a series of new aza-crown ethers
-
A series of aza-crown ethers were synthesised by the in situ reduction of Schiff base crown ethers that were obtained by the condensation of a dialdehyde with a diamine in methanol solution. The aza-crown ethers were characterised by elemental analysis, F
- Hu, Xiao Li,Lu, Guang Nong,Chen, Lei,Yang, Ru Dong
-
p. 356 - 357
(2007/10/03)
-
- Bisoxadiazolidine derivative
-
A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. STR1 each represents a phenylene group L: (1) an oxygen, (2) a STR2 (3) a --S(O)n --, (4) a --CO--, (5) a STR3 (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.
- -
-
-
- Terminal-Terminal Types of Liquid Crystals. I. Synthesis and Electrooptical Properties of a Ferroelectric Liquid Crystal
-
A novel ferroelectric liquid crystal, (S)-bis(2-methylbutyl) 3,3'->bis (EBOPBP) was prepared,which are composed of two chiral mesogenic groups interconnected by a very sho
- Shiraishi, Kohei,Kato, Koichi,Sugiyama, Kazuo
-
p. 1848 - 1850
(2007/10/02)
-
- THERMOTROPIC COMPOUNDS WITH TWO TERMINAL MESOGENIC UNITS AND A CENTRAL SPACER. 5. HOMOLOGOUS SERIES OF POLYMETHYLENE-α, ω-BIS(P-OXYBENZYLIDENE ANILINE)
-
Two series of new thermotropic compounds with two terminal mesogenic units, p-oxybenzylidene-p-substituted anilines, attached to both ends of central polymethylene spacer were prepared.The first series of compounds has central polymethylene spacers of var
- Jin, Jung-Il,Park, Joo-Hoon
-
p. 293 - 308
(2007/10/02)
-
- MESOGENIC POLYMERS. 6. TWO SERIES OF ISOMERIC POLYAZOMETHINES.
-
Two homologoous series of alternating rigid-flexible, main chain liquid crystalline polyimines are reported; one based on terephthaldehyde the other based on p-phenylenediamine. It was found through examination of optical microscopic, x-ray diffraction an
- Griffin,Britt,Hung,Steele
-
p. 305 - 314
(2007/10/02)
-