34074-28-7

Upstream product

• 74-90-8 hydrogen cyanide 
• 104-66-5 1,2-diphenoxyethane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-93-4 ethylene dibromide 
• 25909-66-4 ethylene glycol bis[4-(ethoxycarbonyl)phenyl] ether 
• 107-06-2 1,2-dichloro-ethane 
• 4672-49-5 1,2-bis(methanesulfonyloxy)ethane 
• 54373-15-8 4-(2-chloroethoxy)benzaldehyde 
• 53912-89-3 (2S)-2-(3-pyridyl)piperidine hydrochloride 
• 144-62-7 oxalic acid 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 58765-11-0 4-hydroxybenzaldehyde potassium salt 
• 98-59-9 p-toluenesulfonyl chloride 
• 6315-52-2 1,2-bis-tosyloxyethane 

Downstream Products

• 119415-65-5 1,2-bis-(4-phenethylaminomethyl-phenoxy)-ethane 
• 129720-08-7 (S)-bis(2-methylbutyl) 3,3'-<1,2-ethanediylbis>bis<2-propenoate> 
• 87367-68-8 3-(4-{2-[4-(2,2-Bis-ethoxycarbonyl-vinyl)-phenoxy]-ethoxy}-phenyl)-2-ethoxycarbonyl-acrylic acid ethyl ester 
• 252006-60-3 (2E,2E)-3,3-(4,4-(ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(1-phenylprop-2-en-1-one) 
• 872132-66-6 N'-[1-(4-{2-[4-(Methylsulfanylthiocarbonyl-hydrazonomethyl)-phenoxy]-ethoxy}-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester 

Relevant academic research and scientific papers

The syntheses of 4,4'-(1,n-dioxaalkane)-bisbenzaldehydes and 4,4'-(1,n- dioxaalkane)-bis(α-methoxy phenylacetic acids)

The syntheses of 4,4'-(1,n-dioxaalkane)-bis(α-methoxyphenylacetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4'-(1,n-dioxaalkane)-bisbenz

Synthesis, anti-Trypanosoma cruzi activity and micelle interaction studies of bisguanylhydrazones analogous to pentamidine

Three new bisguanylhydrazones analogous to pentamidine were synthesized, fully characterized and tested as anti-Trypanosoma cruzi candidates. Contrary to literature reports, that bicationic compounds are more active than monocationic compounds against Try

Synthesis, Molecular Docking Studies, and Anticonvulsant Evaluation of Novel bis-Phenylhydrazones against Chemically induced Seizures in Mice

A series of novel bis-phenylhydrazones were synthesized by the condensation of dialdehydes with phenylhydrazine to evaluate them for their anticonvulsant activity. Efficacy of newly synthesized compounds against pentylenetetrazole (PTZ)-induced, strychnin

Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst

Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) which are linked to aliphatic or aromatic spacers via ether or ester linkages were performed in good to excellent yields by the reaction of 5,5-dimethyl-1,3-cyclohexanedione with the appropriate bis-aldehydes using p-TSA as an organic acid solid catalyst. The reaction of the bis-aldehydes with barbituric acid or 1,3-dimethylbarbituric acid instead of 5,5-dimethyl-1,3-cyclohexanedione afforded the corresponding Knoevenagel condensation adducts in good yield.

Synthesis, characterization and anticancer activity of dinuclear ruthenium(II) complexes linked by an alkyl chain

A series of 1,10-phenanthroline-based dinucleating bridging ligands BL1-3 and their dinuclear ruthenium Ru(ii) complexes [(bpy)2Ru(BL1-3)Ru(bpy)2](PF6)4 (bpy = 2,2′-bipyridine; PF6/su

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate

Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent

Synthesis, antitumor activity, enzyme assay, DNA binding and molecular docking of Bis-Schiff bases of pyrazoles

A novel series of Bis-Schiff bases of pyrazoles 9–24 were synthesized by the direct condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly synthesized Bis-Schiff bases of pyrazoles 9–24 were characterized and confirmed by analyt

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

In this work, the new trinuclear manganese catalyst defined as Fe3O4@NFC@NNSM-Mn(iii) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP analysis. There have been reports of the use of magnetic catalysts for the synthesis of xanthine derivatives. The critical potential interest in the present method include short reaction time, high yields, recyclability of the catalyst, easy workup, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. Also, the synthesized catalyst was used as a recyclable trinuclear catalyst in alcohol oxidation reactions at 40 °C. The magnetic catalyst activity of Fe3O4@NFC@NNSM-Mn(iii) could be attributed to the synergistic effects of the catalyst Fe3O4@NFC@NNS-Mn(iii) with melamine. Employing a sustainable and safe low temperature, using an eco-friendly solvent, no need to use any additive, and long-term stability and magnetic recyclability of the catalyst for at least six successive runs are the advantages of the current protocol towards green chemistry. This protocol is a benign, environmentally friendly method for heterocycle synthesis. This journal is

BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA

The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

Biferrocenyl Schiff bases as efficient corrosion inhibitors for an aluminium alloy in HCl solution: A combined experimental and theoretical study

The corrosion inhibitive capabilities of some ferrocene-based Schiff bases on aluminium alloy AA2219-T6 in acidic medium were investigated using Tafel polarization, electrochemical impedance spectroscopy (EIS), weight loss measurement, FT-IR spectroscopy and scanning electron microscopic (SEM) techniques. The influence of molecular configuration on the corrosion inhibition behavior has been explored by quantum chemical calculation. Ferrocenyl Schiff bases 4,4′-((((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcua), 4,4′-((((ethane-1,2-diylbis(oxy))bis(2-methoxy-1,4-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcub) and 4,4′-((((ethane-1,2-diylbis(oxy))bis(2-ethoxy-1,4-phenylene))bis(methaneylylidene))bis(azaneylylidene))bisferrocene (Fcuc) have been synthesized and characterized by FT-IR, 1H and 13C NMR spectroscopic studies. These compounds showed a substantial corrosion inhibition against aluminium alloy in 0.1 M of HCl at 298 K. Fcub and Fcuc showed better anticorrosion efficiency as compared with Fcua due to the electron donating methoxy and ethoxy group substitutions, respectively. Polarization curves also indicated that the studied biferrocenyl Schiff bases were mixed type anticorrosive materials. The inhibition of the aluminium alloy surface by biferrocenyl Schiff bases was evidenced through scanning electron microscopy (SEM) studies. Semi-empirical quantum mechanical studies revealed a correlation between corrosion inhibition efficiency and structural functionalities.