34123-57-4

Basic information

• Product Name: MONODESMETHYL ISOPROTURON
• Synonyms: 1-(4-Isopropylphenly)-3-methylurea;1-Methyl-3-[4-(propan-2-yl)phenyl]urea;isoproturon-monodemethyl
• CAS NO: 34123-57-4
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 34123-57-4.mol

Chemical Properties

• Boiling Point: 272.9°Cat760mmHg
• Flash Point: 99.9°C
• Appearance: /
• Density: 1.059g/cm³
• Vapor Pressure: 0.00592mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: MONODESMETHYL ISOPROTURON(CAS DataBase Reference)
• NIST Chemistry Reference: MONODESMETHYL ISOPROTURON(34123-57-4)
• EPA Substance Registry System: MONODESMETHYL ISOPROTURON(34123-57-4)

Safety Data

• Hazardous Substances Data: 34123-57-4(Hazardous Substances Data)

Usage

Uses

Used in Pesticide Industry:
MONODESMETHYL ISOPROTURON is used as a fungicide for controlling fungal growth in various crops. Its application helps protect plants from diseases and enhances crop yield and quality.
Used in Environmental Monitoring:
As a metabolite of the herbicide isoproturon, MONODESMETHYL ISOPROTURON can be used in environmental monitoring to assess the presence and impact of isoproturon in the environment. This helps in understanding the extent of pesticide contamination and taking necessary measures to mitigate its effects on ecosystems and human health.

InChI:InChI=1/C11H16N2O/c1-8(2)9-4-6-10(7-5-9)13-11(14)12-3/h4-8H,1-3H3,(H2,12,13,14)

Upstream product

• 99-88-7 4-Isopropylaniline 
• 624-83-9 methyl isocyanate 
• 34123-59-6 N-(4-isopropylphenyl)-N',N'-dimethylurea 
• 31027-31-3 4-isopropylphenylisocyanate 
• 74-89-5 methylamine 

Downstream Products

• 62351-02-4 N-methyl-N-isopropylthio-N'-(4-isopropylphenyl)-urea 
• 62385-89-1 N-methyl-N-n-butylthio-N'-(4-isopropylphenyl)-urea 
• 756481-46-6 7-benzyloxymethyl-3-(2-chloro-4-isopropylphenyl)-8-ethyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione 
• 756481-47-7 1-benzyloxymethyl-4-[(2-chloro-4-isopropylphenyl)amino]-2-ethyl-N-methyl-1H-imidazole-5-carboxamide 
• 756481-48-8 7-benzyloxymethyl-3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 756481-20-6 3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 756481-49-9 3-(2-chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 1027973-23-4 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-5-nitroso-1H-pyrimidine-2,4-dione 
• 756481-24-0 5,6-diamino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 756481-32-0 6-amino-1-(2-chloro-4-isopropyl-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 756481-34-2 1-(2-chloro-4-isopropyl-phenyl)-3-methyl-urea 

Relevant articles and documents

Iron(III) photo-induced degradation of isoproturon: correlation between degradation and toxicity.

The degradation of isoproturon photoinduced by Fe(III) was investigated under both artificial and solar light. The monomeric species Fe(OH)2+ present under the experimental conditions ([Fe(III)] = 3 x 10(-4) M) is the main Fe(III) species responsible for

Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6H- purin-6-one and 3,7-dihydro-1H-purine-2,6-dione derivatives as corticotropin-releasing factor1 receptor antagonists

A growing body of evidence suggests that CRF1 receptor antagonism offers considerable therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such as anxiety and depression. A series of novel 1,2,3,7-tetrahydro-6H-purin-6-one and 3,7-dihydro-1H-purine-2, 6-dione derivatives was synthesized and evaluated as corticotropin releasing factor-1 (CRF1) receptor antagonists. Compounds within this series, represented by compound 12d (IC50 = 5.4 nM), were found to be highly potent CRF1 receptor antagonists. In addition, compounds 12d and 12j were determined to be selective CRF1 antagonists. The synthesis, structure-activity relationships and pharmacokinetic properties of compounds within this series is presented.

Antimitotic antitumor agents: Synthesis, structure-activity relationships, and biological characterization of N-aryl-N′-(2-chloroethyl)ureas as new selective alkylating agents

A series of N-aryl-N′-(2-chloroethyl)ureas (CEUs) and derivatives were synthesized and evaluated for antiproliferative activity against a wide panel of tumor cell lines. Systematic structure-activity relationship (SAR) studies indicated that: (i) a branched alkyl chain or a halogen at the 4-position of the phenyl ring or a fluorenyl/indanyl group, (ii) an exocyclic urea function, and (iii) a N′-2-chloroethyl moiety were required to ensure significant cytotoxicity. Biological experiments, such as immunofluorescence microscopy, confirmed that these promising compounds alter the cytoskeleton by inducing microtubule depolymerization via selective alkylation of β-tubulin. Subsequent evaluations demonstrated that potent CEUs were weak alkylators, were non-DNA-damaging agents, and did not interact with the thiol function of either glutathione or glutathione reductase. Therefore, CEUs are part of a new class of antimitotic agents. Finally, among the series of CEUs evaluated, compounds 12, 15, 16, and 27 were selected for further in vivo trials.