34252-44-3

Basic information

• Product Name: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID;2-Methylindazole-3-carboxylic acid;2H-Indazole-3-carboxylic acid,2-methyl-;3-Carboxy-2-methyl-2H-indazole;2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole-3-carboxylic acid;2-Methyl-2H-indazole-3-carboxylicacid97%;Granisetron EP impurity G;2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole
• CAS NO: 34252-44-3
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• EINECS: 1533716-785-6
• Product Categories: Chemical Amines;Amines;Aromatics;Heterocycles
• Mol File: 34252-44-3.mol

Chemical Properties

• Melting Point: 217-219
• Boiling Point: 417.4 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: white solid
• Density: 1.35
• Vapor Pressure: 1.03E-07mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.02±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(34252-44-3)
• EPA Substance Registry System: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(34252-44-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-22
• RIDADR: 2811
• Hazardous Substances Data: 34252-44-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID is used as a reagent for the synthesis of 5-HT2A and 5-HT3 receptor ligands. These ligands are crucial in the development of medications aimed at treating a range of CNS-related disorders. 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID's involvement in the creation of these ligands highlights its importance in the pharmaceutical industry, as it contributes to the advancement of treatments for various neurological conditions.
Used in Research and Development:
In addition to its application in the pharmaceutical industry, 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID is also utilized in research and development. Scientists and researchers employ 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID to study the interactions between 5-HT2A and 5-HT3 receptors and their respective ligands. This knowledge is vital for understanding the underlying mechanisms of CNS-related disorders and for the development of more effective therapeutic strategies.

InChI:InChI=1/C9H8N2O2/c1-11-8(9(12)13)6-4-2-3-5-7(6)10-11/h2-5H,1H3,(H,12,13)

Upstream product

• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 74-88-4 methyl iodide 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 50264-88-5 indazole-3-carbonitrile 
• 109216-61-7 3-methoxycarbonyl-2-methylisoindazole 
• 4498-68-4 ethyl 1H-indazole-3-carboxylate 
• 77-78-1 dimethyl sulfate 
• 186581-53-3 diazomethane 
• 31748-45-5 2-methyl-2H-indazole-3-carbonitrile 

Downstream Products

• 1029643-59-1 3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride 
• 1029643-68-2 N-({1-[2-(2-fluorophenyl)ethyl]piperidin-4-yl}methyl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-72-8 2-methyl-N-[(1-{2-[4-(trifluoromethyl)phenyl]ethyl}piperidin-4-yl)methyl]-2H-indazole-3-carboxamide 
• 1029643-78-4 N-({1-[2-(2,4-difluorophenyl)ethyl]piperidin-4-yl}methyl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-73-9 N-{1-(2-(2-fluorophenyl)ethyl)piperidin-4-yl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-76-2 N-(1-benzylpiperidin-4-yl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-77-3 N-{1-[3-(4-fluorophenyl)propyl]piperidin-4-yl}-2-methyl-2H-indazole-3- carboxamide 
• 1029643-74-0 N-{2-[4-(4-fluorophenyl)piperidin-1-yl]ethyl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-75-1 N-{3-[4-(4-fluorophenyl)piperidin-1-yl]propyl}-2-methyl-2H-indazole-3-carboxamide 
• 1029647-76-4 N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide 
• 1029647-73-1 N-{1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl}-2-methyl-2H-indazole-3-carboxamide 
• 441715-65-7 ethyl (5-chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetate 
• 127472-42-8 endo-N-(9-methyl-9-azabicyclo<3.3.1>nonan-3-yl)-2-methyl-2H-indazole-3-carboxamide 
• 181071-92-1 2-methyl-2H-indazole-3-carbonyl chloride 

Relevant articles and documents

Efficient syntheses of exo-granisetron hydrochloride and other potential impurities present in granisetron hydrochloride, an anti-emetic drug

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS

2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.