342601-30-3

Basic information

• Product Name: 5-(Thiophen-3-yl)nicotinaldehyde
• Synonyms: 5-(Thiophen-3-yl)nicotinaldehyde
• CAS NO: 342601-30-3
• Molecular Formula: C₁₀H₇NOS
• Molecular Weight: 189.23368
• Mol File: 342601-30-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(Thiophen-3-yl)nicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Thiophen-3-yl)nicotinaldehyde(342601-30-3)
• EPA Substance Registry System: 5-(Thiophen-3-yl)nicotinaldehyde(342601-30-3)

Safety Data

• Hazardous Substances Data: 342601-30-3(Hazardous Substances Data)

Upstream product

• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 6165-69-1 Thien-3-ylboronic acid 
• 37669-64-0 (5-bromopyridin-3-yl)methanol 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 223563-61-9 3-(hydroxymethyl)-5-(3-thiophene)pyridine 

Relevant articles and documents

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γ-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.

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The cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl)porphyrin (TMPyP4) binds to quadruplex DNA and is thereby an inhibitor of human telomerase (Wheelhouse et al. J. Am. Chem. Soc. 1998, 120, 3261-3262). Herein the synthesis and telomerase-inhibiting activity of a wide range of analogues of TMPyP4 are reported, from which rules for a structure-activity relationship (SAR) have been discerned: (1) stacking interactions are critical for telomerase inhibition, (2) positively charged substituents are important but may be interchanged and combined with hydrogen-bonding groups, and (3) substitution is tolerated only on the meso positions of the porphyrin ring, and the bulk of the substituents should be matched to the width of the grooves in which they putatively lie. This SAR is consistent with a model presented for the complexation of TMPyP4 with human telomeric quadruplex DNA.