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2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester, also known as clopidogrel methyl ester, is a chemical compound that serves as a key intermediate in the synthesis of the antiplatelet drug clopidogrel. It is a methyl ester derivative of clopidogrel, a medication widely prescribed to prevent blood clots in patients with a history of heart attack, stroke, or peripheral vascular disease. 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester is significant in the pharmaceutical industry due to its antiplatelet and antithrombotic properties, making it a crucial component in medications for various cardiovascular conditions.

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  • 344298-51-7 Structure
  • Basic information

    1. Product Name: 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester
    2. Synonyms: Methyl 2-chloro-4-Methoxypyridine-3-carboxylate;2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester
    3. CAS NO:344298-51-7
    4. Molecular Formula: C8H8ClNO3
    5. Molecular Weight: 201.60702
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 344298-51-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 290℃
    3. Flash Point: 129℃
    4. Appearance: /
    5. Density: 1.288
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester(344298-51-7)
    11. EPA Substance Registry System: 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester(344298-51-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 344298-51-7(Hazardous Substances Data)

344298-51-7 Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester is used as an intermediate in the synthesis of clopidogrel for its antiplatelet and antithrombotic effects. It plays a vital role in the production of medications aimed at preventing blood clots in patients with a history of heart attack, stroke, or peripheral vascular disease.
Used in Cardiovascular Medications:
2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester is used as a precursor in the development of antiplatelet drugs for the treatment and prevention of cardiovascular conditions. Its contribution to the synthesis of clopidogrel makes it an essential component in medications that help manage the risk of blood clot formation in at-risk patients.

Check Digit Verification of cas no

The CAS Registry Mumber 344298-51-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,2,9 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 344298-51:
(8*3)+(7*4)+(6*4)+(5*2)+(4*9)+(3*8)+(2*5)+(1*1)=157
157 % 10 = 7
So 344298-51-7 is a valid CAS Registry Number.

344298-51-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2-chloro-4-methoxynicotinate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:344298-51-7 SDS

344298-51-7Relevant articles and documents

HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS

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Page/Page column 159, (2021/11/13)

Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

2-PYRIDYLOXY-3-ESTER-4-ETHER OREXIN RECEPTOR ANTAGONISTS

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Page/Page column 37, (2015/06/25)

The present invention is directed to 2-pyridyloxy-3-ester-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prev

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