2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

Base Information

Chemical Name:2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester
CAS No.:344298-51-7
Molecular Formula:C₈H₈ClNO₃
Molecular Weight:201.609
Hs Code.:
Mol file:344298-51-7.mol

Synonyms:2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester;Methyl 2-chloro-4-Methoxypyridine-3-carboxylate

Suppliers and Price of 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2-Chloro-4-methoxynicotinate
10mg
$ 45.00

Matrix Scientific
Methyl2-chloro-4-methoxynicotinate 97%
1g
$ 1012.00

Frontier Specialty Chemicals
Methyl2-chloro-4-methoxynicotinate 98%
1g
$ 30.00

Frontier Specialty Chemicals
Methyl2-chloro-4-methoxynicotinate 98%
5g
$ 120.00

Crysdot
Methyl2-chloro-4-methoxynicotinate 95+%
1g
$ 248.00

Crysdot
Methyl2-chloro-4-methoxynicotinate 95+%
5g
$ 941.00

Chemenu
methyl2-chloro-4-methoxynicotinate 95%
5g
$ 888.00

Chemenu
methyl2-chloro-4-methoxynicotinate 95%
1g
$ 234.00

Atlantic Research Chemicals
Methyl2-Chloro-4-methoxynicotinate 95%
1gm:
$ 420.61

Alichem
Methyl2-Chloro-4-methoxynicotinate
5g
$ 855.45

Total 9 raw suppliers

Chemical Property of 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

Chemical Property:

Boiling Point:290℃
Flash Point:129℃
PSA：48.42000
Density:1.288
LogP:1.53020
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Chloro-4-methoxynicotinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

There total 2 articles about 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 442903-28-8
methyl 2,4-dichloronicotinate

: 124-41-4
sodium methylate

: 344298-51-7
methyl 2-chloro-4-methoxynicotinate

Guidance literature:: In methanol; for 16h; Inert atmosphere;

Reference yield:

: 67-56-1
methanol

: 262423-77-8
2,4-dichloronicotinic acid

: 344298-51-7
methyl 2-chloro-4-methoxynicotinate

Guidance literature:: With hydrogenchloride; at 80 ℃;

Reference yield:

: 344298-51-7
methyl 2-chloro-4-methoxynicotinate

: methyl 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-4-methoxypyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h

2: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 5 h / 20 °C

3: triethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;