2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

Base Information

• Chemical Name: 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester
• CAS No.: 344298-51-7
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Mol file: 344298-51-7.mol

Synonyms:2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester;Methyl 2-chloro-4-Methoxypyridine-3-carboxylate

Chemical Property of 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 290℃
• Flash Point: 129℃
• PSA: 48.42000
• Density: 1.288
• LogP: 1.53020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Chloro-4-methoxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester

There total 2 articles about 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 2,4-dichloronicotinate (442903-28-8) + sodium methylate (124-41-4) → methyl 2-chloro-4-methoxynicotinate (344298-51-7)

Guidance literature:

In methanol; for 16h; Inert atmosphere;

Reference yield:

methanol (67-56-1) + 2,4-dichloronicotinic acid (262423-77-8) → methyl 2-chloro-4-methoxynicotinate (344298-51-7)

Guidance literature:

With hydrogenchloride; at 80 ℃;

Reference yield:

methyl 2-chloro-4-methoxynicotinate (344298-51-7) → methyl 2-{[(3R,6R)-1-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-6-methylpiperidin-3-yl]oxy}-4-methoxypyridine-3-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h

2: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 5 h / 20 °C

3: triethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

methanol

2,4-dichloronicotinic acid

methyl 2,4-dichloronicotinate

sodium methylate

Downstream raw materials:

ethyl 2-chloro-4-methoxypyridine-3-carboxylate

Refernces

• 1、 -. "2-PYRIDYLOXY-3-ESTER-4-ETHER OREXIN RECEPTOR ANTAGONISTS". Page/Page column 37. . Retrieved 2015/06/25.