3484-22-8

Basic information

• Product Name: 5-Nitro-2,3,3-trimethylindolenine
• Synonyms: 5-NITRO-2,3,3-TRIMETHYLINDOLENINE;2,3,3-TRIMETHYL-5-NITRO-3H-INDOLE;2,3,3-trimethyl-5-nitro-3h-indol;5-NITRO-2,3,3-TRIMETHYLINDOLE;5-NITRO-2.3.3-TRIMETHYLINDOLENINE HPLC 98.0% YELLOW CRYSTALS OR CRYSTALLINE POWDER;5-Nitro-2,3,3-trimethylindoleninez;2,3,3-trimethyl-5-nitroindole;2,3,3-trimethyl-5-nitro-indole
• CAS NO: 3484-22-8
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• EINECS: 1806241-263-5
• Product Categories: Heterocycle-Indole series
• Mol File: 3484-22-8.mol

Chemical Properties

• Melting Point: 130-131 °C(Solv: ethanol (64-17-5))
• Boiling Point: 315.7ºC at 760 mmHg
• Flash Point: 144.7 ºC
• Appearance: Crystals or crystalline powder
• Density: 1.23 g/cm³
• Vapor Pressure: 0.000798mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: 2-8°C
• PKA: 3.17±0.40(Predicted)
• CAS DataBase Reference: 5-Nitro-2,3,3-trimethylindolenine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-2,3,3-trimethylindolenine(3484-22-8)
• EPA Substance Registry System: 5-Nitro-2,3,3-trimethylindolenine(3484-22-8)

Safety Data

• Hazardous Substances Data: 3484-22-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-Nitro-2,3,3-trimethylindolenine is used as a reactant in the synthesis of various organic compounds, serving as a key intermediate for the production of a range of chemical products.
Used in Dye and Pigment Production:
In the dye and pigment industry, 5-Nitro-2,3,3-trimethylindolenine is used as a precursor for the synthesis of dyes and pigments, contributing to the development of colorants for different applications.
Used in Pharmaceutical Industry:
5-Nitro-2,3,3-trimethylindolenine is used as a precursor in the pharmaceutical industry for the synthesis of various medicinal compounds, playing a crucial role in the development of new drugs.
Safety Considerations:
Due to the presence of a nitro group, 5-Nitro-2,3,3-trimethylindolenine can be potentially explosive and hazardous to human health. It is essential to handle this chemical with care, adhering to proper safety protocols to minimize risks during its use in various applications.

InChI:InChI=1/C11H12N2O2/c1-7-11(2,3)9-6-8(13(14)15)4-5-10(9)12-7/h4-6H,1-3H3

Upstream product

• 91337-77-8 3-methyl-butan-2-one-(4-nitro-phenylhydrazone) 
• 1640-39-7 2,3,3-trimethylindoleniune 
• 563-80-4 3-methyl-butan-2-one 
• 100-16-3 4-nitrophenylhydrazone 
• 3034-19-3 (2-nitrophenyl)hydrazine 
• 636-99-7 4-nitrophenylhydrazine hydrochloride 

Downstream Products

• 140451-71-4 5-nitro-2,3,3-trimethylindolino(1,2-b)oxazoline 
• 64944-14-5 1,2,3,3-tetramethyl-5-nitro-3H-indol-1-ium iodide 
• 773-63-7 5-amino-2,3,3-trimethyl-3H-indole 
• 119374-54-8 1-ethyl-2,3,3-trimethyl-5-nitro-3H-indolium iodide 
• 119374-55-9 1-butyl-5-nitro-2,3,3-trimethylindolium iodide 
• 1146961-58-1 1-(2-hydroxyethyl)-5-nitro-2,3,3-trimethylindoleninium iodide 
• 1355342-74-3 C₁₇H₂₇N₂⁽¹⁺⁾*I^(1-) 
• 1355342-75-4 C₃₀H₃₈N₃O⁽¹⁺⁾*Cl^(1-) 
• 1355342-76-5 C₃₉H₅₂N₃O₂⁽¹⁺⁾*Cl^(1-) 
• 1355342-77-6 C₄₆H₆₆N₅O₃⁽¹⁺⁾*Cl^(1-) 
• 1458033-62-9 1'-ethyl-3',3'-dimethyl-5',6-dinitro-1',3,3',4-tetrahydrospiro[chromene-2,2'-indole] 

Relevant articles and documents

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Heptamethine nitroindole cyanine dye, preparation method and application thereof

The invention discloses a heptamethine nitro indocyanine dye, a preparation method and application thereof, and belongs to the field of polymethine indocyanine dyes and preparation thereof, wherein the structural formula of the heptamethine nitro indocyanine dye is represented by a formula (I). The preparation method comprises the following steps: 1) carrying out a heating reaction on raw materials containing a 2,3,3-trimethyl-nitroindole derivative and a nucleophilic substituted compound under a vacuum condition to obtain an organic ammonium salt; and 2) carrying out a heating reaction on a solution containing the organic ammonium salt obtained in the step 1) and a cycloalkene derivative under a closed condition. The dye has near-infrared light absorption and fluorescence development properties, and can be used as a probe auxiliary agent; and the preparation method has the advantages of short synthesis route, environment-friendly solvent, simple process, avoidance of noble metal catalysis, high yield, high purity and the like, is high in applicability, and can be used for synthesizing products of various structure types.

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Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituents have a great influence on the photochemical properties of molecules, which will further affect their applications. Yet, the effects of substituents on metastable-state photoacids have not been studied systematically. In this work, 16 metastable-state photoacid derivatives were designed and synthesized on the basis of substituents having a large range of σ–π electron–donor–acceptor capabilities. The effects of substituents on the color display [or maximum absorption band(s)], solubility, pKa values, dark/photoacidity, photosensitivity, and relaxation kinetic(s) were investigated in detail. This study will be helpful for the targeted design and synthesis of promising photoacids and the application of their photocontrolled proton-release processes in functional materials/devices.

A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

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