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CAS

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351-03-1

4-Fluoromethamphetamine, also known as 4-FMA, is a synthetic psychoactive substance that belongs to the amphetamine class. It is structurally similar to methamphetamine but with a fluorine atom attached to the 4-position of the phenyl ring. This modification results in a compound that is more potent and longer-lasting than its parent compound. 4-FMA acts as a stimulant, affecting the central nervous system by increasing the release and blocking the reuptake of dopamine, norepinephrine, and serotonin, leading to heightened alertness, euphoria, and increased energy. However, its use is associated with significant health risks, including addiction, cardiovascular issues, and potential neurotoxicity. It is not approved for medical use and is considered a controlled substance in many countries due to its potential for abuse and harmful effects.

351-03-1 Suppliers

This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn't provide relevant sales information.
  • 351-03-1 Structure

  • Basic information

    1. Product Name: 4-Fluoromethamphetamine
    2. Synonyms: Benzeneethanamine,4-fluoro-N,α-dimethyl-;1-(4-Fluorophenyl)-2-(methylamino)propane;p-Fluoro-N,α-dimethylbenzeneethanamine;DL-4-Fluoromethamphetamine;
    3. CAS NO:351-03-1
    4. Molecular Formula: C10H14FN
    5. Molecular Weight: 167.226
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 351-03-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 221.26 °C at 760 mmHg
    3. Flash Point: 87.615 °C
    4. Appearance: N/A
    5. Density: 0.991 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-Fluoromethamphetamine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-Fluoromethamphetamine(351-03-1)
    11. EPA Substance Registry System: 4-Fluoromethamphetamine(351-03-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 351-03-1(Hazardous Substances Data)

351-03-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 351-03-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 351-03:
(5*3)+(4*5)+(3*1)+(2*0)+(1*3)=41
41 % 10 = 1
So 351-03-1 is a valid CAS Registry Number.

351-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluorophenyl)-N-methylpropan-2-amine

1.2 Other means of identification

Product number -
Other names p-Fluoromethamphetamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:351-03-1 SDS

351-03-1Relevant articles and documents

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Matzel, Philipp,Krautschick, Lukas,H?hne, Matthias

, p. 2022 - 2027 (2017/10/07)

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox

Roiban, Gheorghe-Doru,Kern, Marcelo,Liu, Zhi,Hyslop, Julia,Tey, Pei Lyn,Levine, Matthew S.,Jordan, Lydia S.,Brown, Kristin K.,Hadi, Timin,Ihnken, Leigh Anne F.,Brown, Murray J. B.

, p. 4475 - 4479 (2017/12/07)

Chiral secondary and tertiary amines are ubiquitous in pharmaceutical, fine, and specialty chemicals, but their synthesis typically suffers from significant sustainability and selectivity challenges. Biocatalytic alternatives, such as enzyme-catalyzed reductive amination, offer several advantages over traditional chemistry, but industrial applicability has not yet been demonstrated. Herein, we report the use of cell lysates expressing imine reductases operating at 1:1 stoichiometry for a variety of amines and carbonyls. A collection of biocatalysts with diversity in coverage of small molecules and direct industrial applicability is presented.

Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists

Fotsch,Sonnenberg,Chen,Hale,Karbon,Norman

, p. 2344 - 2356 (2007/10/03)

1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC50S less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).

N-2[(4-fluoro-phenyl)-1-methyl]-2-ethyl-N-methyl-N-propynyl amine and the method of use thereof

-

, (2008/06/13)

The invention relates to the new N-[2-/4-fluorophenyl/-1-methyl]-ethyl-N-methyl-N-propynyl amine of the Formula I STR1 and isomers and salts thereof. The compound of the formula I is useful as a selective MAO inhibitor.