4-Fluoromethamphetamine

Base Information

• Chemical Name: 4-Fluoromethamphetamine
• CAS No.: 351-03-1
• Molecular Formula: C10H14FN
• Molecular Weight: 167.226
• Mol file: 351-03-1.mol

Synonyms:Benzeneethanamine,4-fluoro-N,α-dimethyl-;1-(4-Fluorophenyl)-2-(methylamino)propane;p-Fluoro-N,α-dimethylbenzeneethanamine;DL-4-Fluoromethamphetamine;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 4-Fluoromethamphetamine

Chemical Property:

• Boiling Point: 221.26 °C at 760 mmHg
• Flash Point: 87.615 °C
• Density: 0.991 g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoromethamphetamine

There total 6 articles about 4-Fluoromethamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-chloropropyl)-4-fluorobenzene (7387-75-9) + methylamine (74-89-5) → (±)-1-(4-fluorophenyl)-N-methylpropan-2-amine (351-03-1)

Guidance literature:

With ethanol; at 160 ℃;

DOI:10.1021/ja01210a032

Reference yield:

4-fluorophenyl acetone (459-03-0) + methylamine hydrochloride (593-51-1) → (±)-1-(4-fluorophenyl)-N-methylpropan-2-amine (351-03-1)

Guidance literature:

4-fluorophenyl acetone; methylamine hydrochloride; With titanium(IV) isopropylate; triethylamine; In ethanol; for 3h;

With sodium tetrahydroborate; In ethanol; for 3h; Further stages.;

DOI:10.1021/jm0004547

Reference yield:

fluorobenzene (462-06-6) → (±)-1-(4-fluorophenyl)-N-methylpropan-2-amine (351-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: FeCl₃ / -21 - -16 °C

2: ethanol / 160 °C

With ethanol; iron(III) chloride;

DOI:10.1021/ja01210a032

upstream raw materials:

1-(2-chloropropyl)-4-fluorobenzene

methylamine

4-fluorophenyl acetone

methylamine hydrochloride

Downstream raw materials:

(+/-)-N-methyl-N-(2-propenyl)-[2-(4-fluoro-phenyl)-1-methyl]-ethylamine

Refernces

• 1、 Roiban, Gheorghe-Doru,Kern, Marcelo,Liu, Zhi,Hyslop, Julia,Tey, Pei Lyn,Levine, Matthew S.,Jordan, Lydia S.,Brown, Kristin K.,Hadi, Timin,Ihnken, Leigh Anne F.,Brown, Murray J. B.. "Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox". . p. 4475 - 4479. Retrieved 2017/12/07.
• 2、 -. "N-2[(4-fluoro-phenyl)-1-methyl]-2-ethyl-N-methyl-N-propynyl amine and the method of use thereof". . . Retrieved 2008/06/13.