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METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE is a chemical compound that serves as a precursor in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its unique structure, which includes a Boc-protected piperidine moiety and a beta-glycine group. METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE is valuable in medicinal chemistry for its potential to be further modified and incorporated into drug candidates.

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  • TERT-BUTYL 4-AMINO-4-(2-METHOXY-2-OXOETHYL)PIPERIDINE-1-CARBOXYLATE

    Cas No: 362703-57-9

  • USD $ 1.9-2.9 / Gram

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  • 362703-57-9 Structure
  • Basic information

    1. Product Name: METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE
    2. Synonyms: tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;4-Piperidineacetic acid, 4-amino-1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester;4-Amino-1-[(tert-butoxy)carbonyl]-4-piperidineacetic acid methyl ester;tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)
    3. CAS NO:362703-57-9
    4. Molecular Formula: C13H24N2O4
    5. Molecular Weight: 272.343
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 362703-57-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 348℃
    3. Flash Point: 165℃
    4. Appearance: /
    5. Density: 1.096
    6. Vapor Pressure: 5.04E-05mmHg at 25°C
    7. Refractive Index: 1.48
    8. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    9. Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
    10. CAS DataBase Reference: METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE(362703-57-9)
    12. EPA Substance Registry System: METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE(362703-57-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 362703-57-9(Hazardous Substances Data)

362703-57-9 Usage

Uses

Used in Pharmaceutical Industry:
METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE is used as a building block for the development of new pharmaceuticals, particularly for the synthesis of SHP2 protein tyrosine phosphatase inhibitors. These inhibitors are of interest in the treatment of various diseases, including cancer and inflammatory disorders, due to their ability to modulate key signaling pathways involved in these conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE is used as a key intermediate in the synthesis of bioactive molecules. Its unique structure allows for the attachment of various functional groups, enabling the creation of diverse drug candidates with potential therapeutic applications.
Used in Drug Design and Optimization:
METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE is utilized in drug design and optimization processes to improve the potency, selectivity, and pharmacokinetic properties of drug candidates. By incorporating this compound into the molecular structure, researchers can fine-tune the properties of new drugs to enhance their therapeutic efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 362703-57-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,7,0 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 362703-57:
(8*3)+(7*6)+(6*2)+(5*7)+(4*0)+(3*3)+(2*5)+(1*7)=139
139 % 10 = 9
So 362703-57-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H24N2O4/c1-12(2,3)19-11(17)15-7-5-13(14,6-8-15)9-10(16)18-4/h5-9,14H2,1-4H3

362703-57-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 4-amino-4-methoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:362703-57-9 SDS

362703-57-9Downstream Products

362703-57-9Relevant articles and documents

Dual Nickel/Photoredox-Catalyzed Deaminative Cross-Coupling of Sterically Hindered Primary Amines

Dorsheimer, Julia R.,Ashley, Melissa A.,Rovis, Tomislav

supporting information, p. 19294 - 19299 (2021/11/23)

We report a method to activate α-3° amines for deaminative arylation via condensation with an electron-rich aldehyde and merge this reactivity with nickel metallaphotoredox to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. The reaction is accelerated by added ammonium salts. Evidence is provided in support of two roles for the additive: inhibition of nickel black formation and acceleration of the overall reaction rate. We demonstrate a robust scope of amine and haloarene coupling partners and show an expedited synthesis of ALK2 inhibitors.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

-

, (2017/09/27)

The present invention provides compounds, compositions thereof, and methods of using the same.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

-

Paragraph 0255; 0256, (2015/06/17)

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.

Synthesis and structure-activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

Gilmore, John L.,King, Bryan W.,Harris, Cathy,Maduskuie, Thomas,Mercer, Stephen E.,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Ribadeneria, Maria D.,Vaddi, Krishna,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.,Duan, James J.-W.

, p. 2699 - 2704 (2007/10/03)

A novel series of achiral TNF-α converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11 nM in a porcine TACE assay and inhibited TNF-α production in an LPS-stimulated whole blood assay with an IC5

Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha

-

Page/Page column 49, (2010/11/30)

The present application describes novel β-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3

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