Preparation of trifluoromethyl-substituted alcohols from allylsilanes and trifluoroacetic anhydride
The titanium tetrachloride-mediated addition of allyltrimethylsilane or 1,8-bis(trimethylsilyl)-2,6-octadiene and trifluoroacetic anhydride led to trifluoromethyldiallylcarbinol or (dl)-1-trifluoromethyl-2,5- divinylcyclopentanol, respectively, in fair yields; this latter was further converted into several 1-trifluoromethyl-2-vinylcyclopentane derivatives.
Pellissier, Helene,Wilmouth, Serge,Santelli, Maurice
Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines
A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.
Jiang, Biao,Xiong, Xen-Nan,Yang, Cai-Guang
p. 475 - 477
(2007/10/03)
Convenient approaches to 4-trifluoromethylpyridine
A number of approaches to the synthesis of 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)ether in two steps.
Cholesterol biosynthesis inhibitors are described which are derivatives of coenzyme A having the general formula STR1 wherein n is 1 to 3, inclusive, and CoA is coenzyme A minus a hydrogen atom from a sulfhydryl substituent. They are produced by reacting coenzyme A with a fluorinated 3-hydroxy-3-methylglutaric anhydride of the general formula STR2 in dilute aqueous alkali.
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(2008/06/13)
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