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4-ethyl-2-nitro-aniline, a chemical compound with the molecular formula C8H10N2O2, is a yellow crystalline solid. It is classified as a nitroamine, containing both a nitro group and an amine group. 4-ethyl-2-nitro-aniline is primarily utilized in the production of dyes and pigments, as well as in organic synthesis. Due to its hazardous nature, it requires careful handling and adherence to safety protocols to prevent potential health risks.

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  • 3663-35-2 Structure
  • Basic information

    1. Product Name: 4-ethyl-2-nitro-aniline
    2. Synonyms: 4-ethyl-2-nitro-aniline
    3. CAS NO:3663-35-2
    4. Molecular Formula: C8H10N2O2
    5. Molecular Weight: 166.18
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3663-35-2.mol
  • Chemical Properties

    1. Melting Point: 45-47 °C
    2. Boiling Point: 314°Cat760mmHg
    3. Flash Point: 143.7°C
    4. Appearance: /
    5. Density: 1.218g/cm3
    6. Vapor Pressure: 0.000479mmHg at 25°C
    7. Refractive Index: 1.598
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 0.45±0.10(Predicted)
    11. CAS DataBase Reference: 4-ethyl-2-nitro-aniline(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-ethyl-2-nitro-aniline(3663-35-2)
    13. EPA Substance Registry System: 4-ethyl-2-nitro-aniline(3663-35-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3663-35-2(Hazardous Substances Data)

3663-35-2 Usage

Uses

Used in Dye and Pigment Production:
4-ethyl-2-nitro-aniline is used as a key intermediate in the synthesis of various dyes and pigments. Its unique chemical structure allows for the creation of a wide range of colors, making it valuable in the production of textiles, paints, and other color-intensive products.
Used in Organic Synthesis:
In the field of organic synthesis, 4-ethyl-2-nitro-aniline serves as a versatile building block for the development of new compounds. Its presence of both nitro and amine groups enables a variety of chemical reactions, contributing to the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
4-ethyl-2-nitro-aniline is also utilized in research and development settings, where its unique properties are explored for potential applications in new technologies and materials. Its reactivity and structural characteristics make it a valuable compound for scientific investigations and the advancement of chemical knowledge.

Check Digit Verification of cas no

The CAS Registry Mumber 3663-35-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,6 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3663-35:
(6*3)+(5*6)+(4*6)+(3*3)+(2*3)+(1*5)=92
92 % 10 = 2
So 3663-35-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2/c1-2-6-3-4-7(9)8(5-6)10(11)12/h3-5H,2,9H2,1H3

3663-35-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-ethyl-2-nitroaniline

1.2 Other means of identification

Product number -
Other names 4-Aethyl-2-nitro-anilin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3663-35-2 SDS

3663-35-2Relevant articles and documents

Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis

Wang, Xiaoyu,Zhao, Rui,Ji, Wenming,Zhou, Jie,Liu, Quan,Zhao, Linxiang,Shen, Zhufang,Liu, Shuainan,Xu, Bailing

, p. 118 - 127 (2022/01/03)

Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis, and its inhibitors are expected to be novel antidiabetic agents. Herein, a series of new indole and benzofuran analogues were designed and synthesized to evaluate the inhib

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

-

Paragraph 0367; 0368, (2020/08/16)

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Next Generation of Guanidine Quinoline Copper Complexes for Highly Controlled ATRP: Influence of Backbone Substitution on Redox Chemistry and Solubility

R?sener, Thomas,Hoffmann, Alexander,Herres-Pawlis, Sonja

supporting information, p. 3164 - 3175 (2018/07/31)

Ligands DMEG6etqu, TMG6etqu, DMEG6buqu, and TMG6buqu were developed on the basis of guanidine quinoline (GUAqu) ligands 1,3-dimethyl-N-(quinolin-8-yl)imidazolidin-2-imine (DMEGqu) and 1,1,3,3-tetramethyl-2-(quinolin-8-yl)guanidine (TMGqu). These ligands feature an alkyl substituent at the C6 of the quinoline backbone. The synthetic strategy developed here enables inexpensive syntheses of any kind of C6-substituted GUAqu ligands. On one hand, the alkylation increases the solubility of corresponding copper complexes in apolar atom transfer radical polymerization (ATRP) monomers like styrene. On the other hand, it has a significant electronic influence and thus an effect on the donor properties of the new ligands. Seven CuI and CuII complexes of DMEG6etqu and TMG6etqu have been crystallized and were studied with regard to their structural and electrochemical properties. CuI and CuII complexes of DMEG6buqu and TMG6buqu turned out to be perfectly soluble in pure styrene even at room temperature, which makes them excellent catalysts in the ATRP of apolar monomers. The key characteristics of the ATRP equilibrium, KATRP and kact, were determined for the new complexes. In addition, we used our recently developed DFT methodology, NBO analysis, and isodesmic reactions to predict the influence of the introduced alkyl substituents. It turned out that high conformational freedom in the complex structures leads to a significant uncertainty in prediction of the thermodynamic properties.

PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONISTS

-

Page/Page column 36, (2011/02/24)

Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other PAF-mediated disorders, including inflammatory, cardiovascular, and immune disorders.

Concise total synthesis of

Buszek, Keith R.,Brown, Neil,Luo, Diheng

supporting information; experimental part, p. 201 - 204 (2009/06/20)

An efficient nine-step total synthesis of the annulated indole natural products.

Heterocyclic compounds as inhibitors of factor VIIa

-

Page/Page column 83, (2008/06/13)

The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders

-

, (2008/06/13)

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.

2-(4-pyridylaminomethyl)-benzimidazole derivatives having antiviral activity

-

, (2008/06/13)

Provided herein is an antiviral 2-(4-pyridylaminomethyl)-benzimidazole of the formula: STR1 wherein R is a radical selected from the groups consisting of hydrogen, short-chain alkyl, short-chain alkoxy, benzoyl, halogenomethyl, halogen, nitro and amino groups; the preparation of these compounds and antiviral composition containing such compounds.

Process for the production of 2-aryl-2H-benzotriazoles

-

, (2008/06/13)

A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an alkaline medium at a pH over 10 in the presence of a nickel catalyst, preferably molybdenum-promoted Raney nickel. High yields of pure product are obtained directly with a concomitant reduction of undesired by-product and a reduction in effluent pollution problems.

Process for the production of 2-aryl-2H-benzotriazoles

-

, (2008/06/13)

A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an organic solvent mixture containing an organic amine at a pH over 10 in the presence of noble metal hydrogenation catalyst, preferably palladium. High yields of pure product are obtained with a concomitant reduction of undesired by-products and a reduction in effluent pollution problems.

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