369-33-5

Basic information

• Product Name: 3',4'-Difluoroacetophenone
• Synonyms: 1-(3,4-Difluorophenyl)ethan-1-one;1-(3,4-DIFLUORO-PHENYL)-ETHANONE;3',4'-DIFLUOROACETOPHENONE;3,4-DIFLUOROACETOPHENONE;OTAVA-BB BB7020410077;Ethanone, 1-(3,4-difluorophenyl)-;3,4-Difluoroacetophenone,98%;3',4'-Difluoro
• CAS NO: 369-33-5
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.13
• EINECS: 206-717-7
• Product Categories: Acetophenone Series;Aromatic Acetophenones & Derivatives (substituted);ketone;Miscellaneous;Adehydes, Acetals & Ketones;Fluorine Compounds;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 369-33-5.mol

Chemical Properties

• Melting Point: 19-20 °C(lit.)
• Boiling Point: 94-95 °C13 mm Hg(lit.)
• Flash Point: 167 °F
• Appearance: clear yellowish liquid after melting
• Density: 1.246 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.237mmHg at 25°C
• Refractive Index: n20/D 1.4916(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: INSOLUBLE
• BRN: 2206856
• CAS DataBase Reference: 3',4'-Difluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-Difluoroacetophenone(369-33-5)
• EPA Substance Registry System: 3',4'-Difluoroacetophenone(369-33-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 369-33-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3',4'-Difluoroacetophenone is used as an intermediate in the synthesis of various organic compounds, particularly those requiring fluorinated aromatic rings. Its application in this field is due to its unique reactivity and the ability to introduce fluorine atoms into the molecular structure, which can significantly alter the properties of the final product.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3',4'-Difluoroacetophenone is used as a building block for the development of new drugs with potential applications in various therapeutic areas. The presence of fluorine atoms can enhance the lipophilicity, metabolic stability, and overall pharmacokinetic profile of the resulting drug molecules, making them more effective and suitable for clinical use.
Used in Material Science:
3',4'-Difluoroacetophenone can also be employed in the field of material science, where it may be used to synthesize novel materials with specific properties. The incorporation of fluorine atoms into the molecular structure can lead to materials with improved thermal stability, chemical resistance, and other desirable characteristics for various applications, such as in coatings, adhesives, or polymers.

InChI:InChI=1/C8H6F2O/c1-5(11)6-2-3-7(9)8(10)4-6/h2-4H,1H3

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 676-58-4 methylmagnesium chloride 
• 188345-25-7 3,4-difluoro-N-methoxy-N-methylbenzamide 
• 76903-88-3 3,4-difluorobenzoyl chloride 
• 276875-21-9 1-(3,4-difluorophenyl)ethanamine 
• 143874-13-9 4-ethynyl-1,2-difluorobenzene 
• 17049-49-9 octylmagnesium bromide 
• 455-86-7 3,4-Difluorobenzoic acid 

Downstream Products

• 455-86-7 3,4-Difluorobenzoic acid 
• 79784-34-2 3,4-difluorophenylglyoxal 
• 71682-97-8 3-(3,4-difluorophenyl)-3-oxopropanenitrile 
• 40706-98-7 3,4-difluorophenacyl bromide 
• 252955-07-0 ethyl 3-(3,4-difluorophenyl)-3-oxopropanoate 
• 244263-36-3 Allyl-[1-(3,4-difluoro-phenyl)-eth-(E)-ylidene]-amine 
• 74445-75-3 1-(3,4-difluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione 

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