36904-76-4

Basic information

• Product Name: α-methyltetronic acid
• Synonyms: tetrinic acid;α-methyltetronic acid;4-Hydroxy-5-methyl-2(5H)-furanone;5-Methyl-4-hydroxyfuran-2(5H)-one;4-hydroxy-5-methyl-5H-furan-2-one
• CAS NO: 36904-76-4
• Molecular Formula: C₅H₆O₃
• Molecular Weight: 114.09934
• Mol File: 36904-76-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-methyltetronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-methyltetronic acid(36904-76-4)
• EPA Substance Registry System: α-methyltetronic acid(36904-76-4)

Safety Data

• Hazardous Substances Data: 36904-76-4(Hazardous Substances Data)

Upstream product

• 4949-44-4 ethyl propanoylacetate 
• 36187-69-6 ethyl 4-bromo-3-oxopentanoate 
• 128766-62-1 6-(1-Acetoxyethyl)-2,2-dimethyl-1,3-dioxin-4-one 
• 72324-46-0 6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one 
• 75-07-0 acetaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 128766-64-3 6-(1-Hydroxyethyl)-2,2-dimethyl-1,3-dioxin-4-one 

Downstream Products

• 69556-76-9 (+/-)-4-Benzyloxy-5-methyl-2,5-dihydrofuran-2-one 
• 94512-60-4 4-(4-Hydroxy-5-methyl-2-oxo-2,5-dihydro-furan-3-ylazo)-benzoic acid ethyl ester 
• 94512-54-6 4-Hydroxy-5-methyl-3-(3-nitro-phenylazo)-5H-furan-2-one 
• 94512-52-4 3-(3,4-Dichloro-phenylazo)-4-hydroxy-5-methyl-5H-furan-2-one 
• 94512-49-9 3-(2-Chloro-phenylazo)-4-hydroxy-5-methyl-5H-furan-2-one 
• 94512-48-8 4-Hydroxy-5-methyl-3-phenylazo-5H-furan-2-one 
• 94512-56-8 4-Hydroxy-5-methyl-3-(4-nitro-phenylazo)-5H-furan-2-one 
• 94512-59-1 4-(4-Hydroxy-5-methyl-2-oxo-2,5-dihydro-furan-3-ylazo)-benzoic acid 
• 94512-50-2 3-(4-Chloro-phenylazo)-4-hydroxy-5-methyl-5H-furan-2-one 
• 94512-58-0 4-Hydroxy-5-methyl-3-(3-trifluoromethyl-phenylazo)-5H-furan-2-one 
• 94512-51-3 3-(2,4-Dichloro-phenylazo)-4-hydroxy-5-methyl-5H-furan-2-one 
• 52599-74-3 3-(2-phenyl-acetyl)-5-methyl-tetronic acid 
• 69556-71-4 (RS)-4-methoxy-5-methyl-5H-furan-2-one 

Relevant articles and documents

IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17

The present application discloses compounds having the following formula: (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

SPIRO - FUSED PIPERIDINE DERIVATIVES FOR USE AS INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir11) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

An effective one-pot synthesis of 5-substituted tetronic acids

An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1,3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.