373-14-8

Basic information

• Product Name: 1-FLUOROHEXANE
• Synonyms: 1-fluoro-hexan;1-hexylfluoride;Fluorohexane;hexane,1-fluoro-;Hexylfluorid;HEXYL FLUORIDE;1-FLUOROHEXANE;N-HEXYL FLUORIDE
• CAS NO: 373-14-8
• Molecular Formula: C₆H₁₃F
• Molecular Weight: 104.17
• EINECS: 206-763-8
• Product Categories: Organics
• Mol File: 373-14-8.mol

Chemical Properties

• Melting Point: -103°C
• Boiling Point: 93 °C
• Flash Point: 81 °F
• Appearance: clear colorless liquid
• Density: 0.8 g/mL at 25 °C(lit.)
• Vapor Pressure: 60.6mmHg at 25°C
• Refractive Index: n20/D 1.3755(lit.)
• Storage Temp.: Flammables area
• CAS DataBase Reference: 1-FLUOROHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUOROHEXANE(373-14-8)
• EPA Substance Registry System: 1-FLUOROHEXANE(373-14-8)

Safety Data

• Hazard Codes: T,F
• Statements: 10-23/24/25-36/37/38
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2929 6.1/PG 2
• WGK Germany: 3
• RTECS: MO3675000
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 373-14-8(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C6H13F/c1-2-3-4-5-6-7/h2-6H2,1H3

Upstream product

• 544-10-5 1-Chlorohexane 
• 111-25-1 1-bromo-hexane 
• 16156-50-6 n-hexyl methanesulfonate 
• 3839-35-8 4-methylbenzenesulfonic acid n-hexylester 
• 5337-36-0 trihexyl borate 
• 4665-33-2 2-hexyl-1,1-diphenyl-isourea; hydrofluoride 
• 111-27-3 hexan-1-ol 
• 110-54-3 hexane 
• 107-21-1 ethylene glycol 
• 111-46-6 diethylene glycol 
• 81956-87-8 (η(5)-C5Me5)2HfH2 
• 559-40-0 octaperfluorocyclopentene 

Downstream Products

• 18589-27-0 2-iodohexane 
• 638-45-9 1-Iodohexane 
• 110-54-3 hexane 
• 1595-01-3 1-hexyl-4-methyl-benzene 
• 1077-16-3 hexylbenzene 
• 4468-42-2 3-phenylhexane 
• 6031-02-3 2-phenylhexane 

Relevant articles and documents

Molybdenum oxide-mediated facile aliphatic nucleophilic fluorination

A facile aliphatic nucleophilic fluorination with cesium fluoride in the presence of molybdenum oxide as a catalyst has been demonstrated. Reactivity of molybdenum oxide in nanocrystal form was found to be chemoselective in the presence of water. Furthermore, the reaction is highly specific with alkyl sulfonate substrates.

Visible light-promoted metal-free sp3-C-H fluorination

Photoexcited acetophenone can catalyze the fluorination of unactivated C(sp3)-H groups. While acetophenone, a colorless oil, only has a trace amount of absorption in the visible light region, its photoexcitation can be achieved by irradiation with light generated by a household compact fluorescent lamp (CFL). This operational simple method provides improved substrate scope for the direct incorporation of a fluorine atom into simple organic molecules. CFL-irradiation can also be used to promote certain classic UV-promoted photoreactions of colorless monoarylketones and enones/enals.

Activation of aromatic, aliphatic, and olefinic carbon-fluorine bonds using Cp*2HfH2

The hafnium hydride Cp*2HfH2 is reacted with a series of fluorocarbons to examine the scope of C-F bond activation. Aromatic, vinylic, and aliphatic C-F bonds all show some degree of reactivity, and possible mechanisms are discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

A useful conversion of alcohols to alkyl fluorides

A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.

Thermically-Initiated Fluorinations at Saturated Carbon Atoms with Xenon Difluoride

The heating of several hydrocarbons with xenon difluoride at 95-120 deg C in stainless steel reactor equipped with teflon jackets resulted in mono-, di-, and trisubstituted products.