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CAS

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373604-52-5

6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 373604-52-5 Structure

  • Basic information

    1. Product Name: 6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile
    2. Synonyms:
    3. CAS NO:373604-52-5
    4. Molecular Formula:
    5. Molecular Weight: 385.65
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 373604-52-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile(373604-52-5)
    11. EPA Substance Registry System: 6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile(373604-52-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 373604-52-5(Hazardous Substances Data)

373604-52-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 373604-52-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,3,6,0 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 373604-52:
(8*3)+(7*7)+(6*3)+(5*6)+(4*0)+(3*4)+(2*5)+(1*2)=145
145 % 10 = 5
So 373604-52-5 is a valid CAS Registry Number.

373604-52-5Relevant articles and documents

Adenosine kinase inhibitors: Polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

Zheng, Guo Zhu,Mao, Yue,Lee, Chih-Hung,Pratt, John K.,Koenig, John R.,Perner, Richard J.,Cowart, Marlon D.,Gfesser, Gregory A.,McGaraughty, Steve,Chu, Katharine L.,Zhu, Chang,Yu, Haixia,Kohlhaas, Kathy,Alexander, Karen M.,Wismer, Carol T.,Mikusa, Joseph,Jarvis, Michael F.,Kowaluk, Elizabeth A.,Stewart, Andrew O.

, p. 3041 - 3044 (2007/10/03)

We have discovered that polar 7-substituents of pyridopyrimidine derivatives affect not only whole cell AK inhibitory potency, but also selectivity in causing locomotor side effects in vivo animal models. We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity.

Pyridopyrimidine analogues as novel adenosine kinase inhibitors

Zheng, Guo Zhu,Lee, Chih-Hung,Pratt, John K.,Perner, Richard J.,Jiang, Mei Qun,Gomtsyan, Arthur,Matulenko, Mark A.,Mao, Yui,Koenig, John R.,Kim, Ki H.,Muchmore, Steve,Yu, Haixia,Kohlhaas, Kathy,Alexander, Karen M.,McGaraughty, Steve,Chu, Katharine L.,Wismer, Carol T.,Mikusa, Joseph,Jarvis, Michael F.,Marsh, Kennan,Kowaluk, Elizabeth A.,Bhagwat, Shripad S.,Stewart, Andrew O.

, p. 2071 - 2074 (2007/10/03)

A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2′ substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors.

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