265105-63-3

Basic information

• Product Name: 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime
• CAS NO: 265105-63-3
• Molecular Formula: C₂₈H₂₈BrN₇O₂
• Molecular Weight: 574.48506
• Mol File: 265105-63-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime(265105-63-3)
• EPA Substance Registry System: 1-[5-[4-Amino-5-(3-bromophenyl)pyrido[2,3-d]pyrimidin-7-yl]pyridin-2-yl]piperidin-4-one O-(tetrahydropyran-4-yl)oxime(265105-63-3)

Safety Data

• Hazardous Substances Data: 265105-63-3(Hazardous Substances Data)

Upstream product

• 727381-62-6 5'-acetyl-2,3,5,6-tetrahydro-[1,2']bipyridinyl-4-one O-(tetrahydro-pyran-4-yl)-oxime 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 77287-34-4 formamide 
• 727384-71-6 6''-amino-4''-(3-bromo-phenyl)-4-(tetrahydro-pyran-4-yloxyimino)-3,4,5,6-tetrahydro-2H-[1,2';5',2'']terpyridine-5''-carbonitrile 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 923034-23-5 dimethyl 2-(6-chloronicotinoyl)malonate 
• 2972-74-9 2-(3-bromobenzylidene)malononitrile 
• 3132-99-8 m-bromobenzoic aldehyde 
• 373604-52-5 6-amino-4-(3-bromo-phenyl)-6'-chloro-[2,3']bipyridinyl-5-carbonitrile 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 214698-56-3 5-(3-bromo-phenyl)-7-(6-chloro-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine 

Relevant articles and documents

Adenosine kinase inhibitors: Polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

We have discovered that polar 7-substituents of pyridopyrimidine derivatives affect not only whole cell AK inhibitory potency, but also selectivity in causing locomotor side effects in vivo animal models. We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity.