374794-77-1

Basic information

• Product Name: N-Boc-3-Methylpiperidin-4-one
• Synonyms: N-Boc-3-Methylpiperidin-4-one;4-Methyl-3-oxo-1-piperidinecarboxylic acid tert-butyl ester;4-Methyl-3-oxo-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-methyl-3-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-methyl-3-oxo-, 1,1-dimethylethyl ester
• CAS NO: 374794-77-1
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27346
• Mol File: 374794-77-1.mol

Chemical Properties

• Boiling Point: 298.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.060
• PKA: -1.67±0.40(Predicted)
• CAS DataBase Reference: N-Boc-3-Methylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-3-Methylpiperidin-4-one(374794-77-1)
• EPA Substance Registry System: N-Boc-3-Methylpiperidin-4-one(374794-77-1)

Safety Data

• Hazardous Substances Data: 374794-77-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Boc-3-Methylpiperidin-4-one is used as a component of blocks or precursors for the manufacturing of various drugs. Its versatile chemical reactivity and distinct polar as well as nonpolar sections make it a valuable compound in drug synthesis. It plays a crucial role in the development of new pharmaceutical products, contributing to the advancement of medicine and healthcare.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1408076-42-5 4-methylpiperidin-3-one hydrochloride 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 1121-19-3 4-methylpyridin-3-ol 
• 175406-94-7 1-benzyl-3-oxopiperidine-4-carboxylic acid methyl ester 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 1188264-78-9 trans-(RS)-1,1-dimethylethyl 3-hydroxy-4-methylpiperidinecarboxylate 

Downstream Products

• 1260590-51-9 N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-D]pyrimidin-4-amine hydrochloride 
• 1207853-61-9 (3R,4R)-3-amino-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 1312762-43-8 (3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 1312762-44-9 (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 374794-78-2 (RS)-3,3-Difluoro-4-methylpiperidine Hydrochloride 

Relevant articles and documents

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Selective α-Methylation of Ketones

The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.

A method for synthesis of piperidine derivatives (by machine translation)

The invention discloses a method for synthesis of piperidine derivatives. The piperidine derivatives of the formula (I) of the tartrate: Wherein R1 Is an amino protecting group, R2 Is phenyl or alkyl substituted phenyl, R3 Is C1 - C6 alkyl; by the piperidine derivative having the structural formula (II) with a compound L - tartaric acid reaction, then the obtained through separation, In the having piperidine 3 bit reference into the S on amino-substituted radical, can significantly improve the for tartaric acid from L - In the separate The effect of the. The method can be used for the synthesis of pharmaceutical Tofacitinib, in order to improve the yield of drug Tofacitinib. (by machine translation)

The protection of the nitrogen of (3R, 4R) -3 - methylamino -4 - methyl piperidine asymmetric synthesis method, relevant intermediate and a method for preparing raw materials thereof

The invention relates to a preparation method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I). The method comprises the following steps: carrying out a reductive amination reaction on a compound of formula (III) and (R)-1-phenylethylamine to obtain a compound of formula (II), removing chiral prosthetic groups from the compound of formula (II), and adding a methyl group to the amino group of the compound of formula (II) in order to obtain nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I), wherein R in each of the formula (I), the formula (II) and the formula (III) is an amino protection group or hydrogen, and the amino protection group can be C1-4 alkoxycarbonyl, benzyloxycarbonyl or benzyl groups which can be removed through hydrolysis or hydrogenation. The asymmetric synthesis method of nitrogen protected (3R,4R)-3-methylamino-4-methylpiperidine (I) has the advantages of reasonable technology, concise route, obtaining of the required product in a high ee value manner by constructing two chiral centers through chiral induced one-step reductive amination, cheap raw materials, and no waste isomer emission, and is suitable for large-scale industrialized production.

Cyclohexyl derivatives and their use as therapeutic agents

The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Cyclohexane derivatives and their use as therapeutic agents

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.