375358-19-3

Basic information

• Product Name: 2-CHLORO-QUINOLIN-7-OL
• Synonyms: 2-CHLORO-QUINOLIN-7-OL;2-chloro-7-Quinolinol
• CAS NO: 375358-19-3
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.6
• Mol File: 375358-19-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-QUINOLIN-7-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-QUINOLIN-7-OL(375358-19-3)
• EPA Substance Registry System: 2-CHLORO-QUINOLIN-7-OL(375358-19-3)

Safety Data

• Hazardous Substances Data: 375358-19-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-QUINOLIN-7-OL is used as an active pharmaceutical ingredient for the development of antiseptics and disinfectants. Its antimicrobial properties make it effective in killing or inhibiting the growth of microorganisms, thus preventing infections and promoting wound healing.
Used in Agrochemical Industry:
2-CHLORO-QUINOLIN-7-OL is used as a key component in the formulation of pesticides. Its antifungal properties help protect crops from fungal infections, ensuring higher crop yields and better quality produce.
Used in Synthesis of Pharmaceuticals and Agrochemicals:
2-CHLORO-QUINOLIN-7-OL serves as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new and innovative products with improved efficacy and safety profiles.
Used in Material Science and Nanotechnology:
2-CHLORO-QUINOLIN-7-OL has potential applications in the field of material science and nanotechnology. Its unique properties can be harnessed to develop new materials with enhanced performance characteristics, such as improved conductivity, stability, or biocompatibility.

Upstream product

• 70500-72-0 7-hydroxy-1H-quinolin-2-one 
• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 49609-15-6 2-chloro-7-methoxyquinoline 
• 23981-26-2 7-methoxyquinolin-2(1H)-one 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 105905-82-6 (E)-ethyl 3-(4-methoxy-2-nitrophenyl)acrylate 
• 70500-72-0 quinoline-2,7-diol 

Downstream Products

• 913611-97-9 Brexpiprazole 
• 49609-15-6 2-chloro-7-methoxyquinoline 
• 1374107-24-0 2-(4-diethylaminophenyl)-7-(2-hydroxy-1-tosyloxymethylethoxy)quinoline 
• 1374109-09-7 C₃₃H₃₃F₃N₂O₇S 
• 1374109-08-6 C₂₈H₂₅F₃N₂O₆S 
• 1374109-07-5 C₃₄H₃₉F₃N₂O₆SSi 
• 1374109-06-4 C₁₈H₁₃F₃N₂O₂ 
• 1374107-50-2 2-(4-ethylmethylaminophenyl)-7-[(3-fluoro-2-hydroxy)propoxy]quinoline 
• 1374109-05-3 C₂₈H₃₀N₂O₅S 
• 1374109-04-2 C₃₄H₄₄N₂O₅SSi 
• 1374109-03-1 C₁₈H₁₈N₂O 
• 1374109-02-0 THK-951 
• 1374109-01-9 C₂₅H₃₀N₂O₄ 
• 1374107-48-8 7-[(3-fluoro-2-hydroxy)propoxy]-2-(4-dimethylaminophenyl)quinoline 

Relevant articles and documents

METTL3 MODULATORS

Provided are compounds of Formula (I') or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.

SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5

The disclosure is directed to methods of treating disease using compounds of Formula (I).

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND ITS INTERMEDIATES

The present invention discloses to a process for the preparation of brexpiprazole and its pharmaceutically acceptable salt. The present invention further discloses novel intermediates and process for the preparation of the novel intermediates of brexpiprazole. The invention also discloses a process for purification of brexpiprazole to reduce or eliminate impurities.

Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)

The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory dis

TAU IMAGING PROBE

An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.