49609-15-6

Basic information

• Product Name: 2-Chloro-7-Methoxyquinoline
• Synonyms: 2-Chloro-7-Methoxyquinoline;QUINOLINE, 2-CHLORO-7-METHOXY-
• CAS NO: 49609-15-6
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.62962
• Mol File: 49609-15-6.mol

Chemical Properties

• Melting Point: 97-98 °C
• Boiling Point: 145 °C(Press: 0.6 Torr)
• Appearance: /
• Density: 1.267±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.65±0.50(Predicted)
• CAS DataBase Reference: 2-Chloro-7-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-7-Methoxyquinoline(49609-15-6)
• EPA Substance Registry System: 2-Chloro-7-Methoxyquinoline(49609-15-6)

Safety Data

• Hazardous Substances Data: 49609-15-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-7-Methoxyquinoline is utilized as a precursor in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits. 2-Chloro-7-Methoxyquinoline's reactivity and functional groups make it a valuable building block in medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 2-Chloro-7-Methoxyquinoline serves as a key intermediate in the production of various agrochemicals. Its incorporation into these products can enhance their effectiveness in controlling pests and diseases, thereby contributing to improved crop yields and food security.
Used in Antimicrobial Research:
2-Chloro-7-Methoxyquinoline has been studied for its antimicrobial properties, making it a potential candidate for the development of new antimicrobial agents. Its ability to inhibit the growth of various microorganisms could lead to the creation of novel treatments for infectious diseases.
Used in Anticancer Research:
2-Chloro-7-Methoxyquinoline has also been investigated for its anticancer properties, with research exploring its potential to target and inhibit the growth of cancer cells. As a result, 2-Chloro-7-Methoxyquinoline may contribute to the development of innovative cancer therapies, offering new hope for patients and healthcare professionals.

Upstream product

• 375358-19-3 2-chloroquinoline-7-ol 
• 74-88-4 methyl iodide 
• 23981-26-2 7-Methoxy-carbostyril 
• 70500-72-0 quinoline-2,7-diol 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 105905-82-6 (E)-ethyl 3-(4-methoxy-2-nitrophenyl)acrylate 
• 23981-26-2 7-methoxyquinolin-2(1H)-one 
• 15116-41-3 N-(3-methoxyphenyl)cinnamamide 
• 536-90-3 m-Anisidine 

Downstream Products

• 375358-19-3 2-chloroquinoline-7-ol 
• 1013060-14-4 C₂₅H₃₂N₄O₂ 
• 1013060-11-1 C₂₄H₃₀N₄O₂ 
• 1013060-08-6 C₂₃H₂₈N₄O₂ 

Relevant articles and documents

BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS

Described herein are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R 4, Y1, Y2, n and p are as defined herein.

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory dis

TRIAZOLO-PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxylphenoxy}propionic acid (XK469)

XK469 (1) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories. Subsequent developmental studies led to the entry of (R)-(+) 1 (NSC 698215) into phase 1 clinical trials (NIH UO1-CA62487). The antitumor me