378-77-8

Basic information

• Product Name: SODIUM PENTAFLUOROPROPIONATE
• Synonyms: SODIUM PENTAFLUOROPROPIONATE;PROPANOIC ACID, PENTAFLUORO-, SODIUM SALT;PENTAFLUORO PROPIONIC SODIUM SALT;PENTAFLUOROPROPIONIC ACID SODIUM SALT;PERFLUOROPROPIONIC ACID SODIUM SALT;pentafluoro-propanoicacisodiumsalt;PENTAFLUOROPROPIONIC ACID SODIUM SALT 98%;Sodium pentafluoropropionate 98%
• CAS NO: 378-77-8
• Molecular Formula: C₃F₅O₂*Na
• Molecular Weight: 186.01
• EINECS: 206-830-1
• Mol File: 378-77-8.mol

Chemical Properties

• Melting Point: 226-229 °C (dec.)(lit.)
• Boiling Point: 93.5 °C at 760 mmHg
• Flash Point: 10.3 °C
• Appearance: White crystalline powder
• Density: 1.64g/cm³
• Vapor Pressure: 35.8mmHg at 25°C
• Sensitive: Hygroscopic
• BRN: 3636648
• CAS DataBase Reference: SODIUM PENTAFLUOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM PENTAFLUOROPROPIONATE(378-77-8)
• EPA Substance Registry System: SODIUM PENTAFLUOROPROPIONATE(378-77-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10
• HazardClass: IRRITANT, HYGROSCOPIC
• Hazardous Substances Data: 378-77-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Sodium Pentafluoropropionate is used as a chemical intermediate for the preparation of various organotin compounds, such as tributyltin pentafluoropropionate (Bu3SnO2CC2F5) and trimethyltin pentafluoropropionate. These organotin compounds have applications in the fields of polymerization, biocides, and as catalysts in the chemical industry.
Used in Pharmaceutical Industry:
Sodium Pentafluoropropionate is used as a synthetic precursor for the development of new o-fluoroalkyl-benzenesulfonamide derivatives. These derivatives hold potential applications in the pharmaceutical industry, particularly in the design and synthesis of novel drugs with improved pharmacological properties and therapeutic effects.

InChI:InChI=1/C3HF5O2/c4-2(5,1(9)10)3(6,7)8/h(H,9,10)/p-1

Upstream product

• 754-34-7 1,1,1,2,2,3,3-heptafluoro-3-iodo-propane 
• 378-75-6 perfluoropropionic acid methyl ester 
• 356-45-6 bis(pentafluoropropionyl)peroxide 
• 24163-39-1 sodium 2-nitropropane 
• 91113-96-1 2-nitro-butane; sodium salt 
• 78726-26-8 methyl 2-cyclohexen-2-yl-n-propionate 
• 87375-48-2 1,1-dichloroperfluoro-2-butanone 
• 74179-26-3 methyl 2-cyclohexen-2-yl-n-butyrate 
• 87375-46-0 1-chloroheptafluoro-2-butanone 
• 87375-47-1 1,1,1-trichloropentafluoro-2-butanone 
• 2723-38-8 cyclopentylacetic acid methyl ester 
• 138805-26-2 cis/trans-1-Chloroheptafluoro-1-butene 
• 18027-10-6 sodium trimethylsilanolate 
• 378-00-7 difluoromethylene-heptafluoropropyl-amine 

Downstream Products

• 60979-14-8 1-nitro-4-(1,1,2,2,2-pentafluoroethyl)-benzene 
• 118559-17-4 1-chloro-4-(pentafluoroethyl)benzene 
• 426-60-8 1,4-bis(perfluoroethyl)benzene 
• 455-13-0 4-Iodobenzotrifluoride 
• 473-28-9 1-(pentafluoroethyl)-4-(trifluoromethyl)benzene 
• 422-61-7 perfluoropropanoyl fluoride 
• 76-15-3 Chloropentafluoroethane 
• 354-55-2 bromopentafluoroethane 
• 422-64-0 pentafluoropropionic acid 
• 177174-48-0 2-Methoxy-5-pentafluoroethyl-benzoic acid methyl ester 
• 205192-98-9 1-methoxy-4-nitro-2-(perfluoroethyl)benzene 
• 116-14-3 polytetrafluoroethylene 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 378-75-6 perfluoropropionic acid methyl ester 

Relevant articles and documents

Products formed at intermediate stages of electrochemical perfluorination of propionyl and n-butyryl chlorides. Further evidence in support of NiF 3 mediated free radical pathway

The partially fluorinated HF soluble intermediates formed during the electrochemical perfluorination of propionyl chloride (PC) and n-butyryl chloride (n-BC) were analyzed after passing 0%, 25%, 50%, 75% and 100% of theoretical charge required for the fluorination of PC and n-BC. The acid fluorides formed were converted to their corresponding sodium salt by alkali treatment and were separated by methanol extraction. The methanol was subsequently removed from the extract by vacuum distillation and the residue containing partially fluorinated sodium carboxylates was analyzed using 19F and 1H NMR spectra. Initial perfluorination on activated electrode surface indicates the operation of 'zipper-mechanism'. Formation of partially fluorinated product mixture, initial selectivity towards primary and secondary carbon, carbon chain isomerization and formation of cleaved and coupled products support the general operation of free radical pathway in the overall electrochemical process.

Synthesis and some properties of 1-chloro(bromo)heptafluoro-1-butenes and their epoxy derivatives

1-Chloro- and 1-bromoheptafluoro-1-butenes have been synthesized by chlorination (bromination) of 1,2,3,3,4,4,4-heptafluoro-1-butene and subsequent dehydrohalogenation of the resulting 1,2-dichloro-and 1,2-dibromo-l,2,3,3,4,4,4-heptafluorobutanes with aqueous alkali. 1-Chloro- and l-bromo-l,2-epoxy-heptafluorobutanes have been obtained by oxidation of the title alkenes with molecular oxygen under UV irradiation. In the presence of fluoride ion, the epoxy derivatives undergo isomerization into α-chloro(bromo)-hexafluorobutyryl fluorides; the reaction with antimony pentafluoride yields 1-chloro(bromo)-heptafluoro-2-butanones.

Preparation of anhydrous organic acid salts

One-step process for preparing anhydrous, organic acid alkali or alkaline earth metal salts by contacting and reacting an organic or polymeric acid fluoride, anhydride or ester and an organic alkali or alkaline earth metal silanolate.

A NEW METHOD FOR THE PREPARATION OF PERFLUOROCARBOXYLIC ACIDS

The reaction of both primary perfluoroalkyl iodides and bromides containing 3-12 carbon atoms with a rongalite-NaHCO3 reagent in aqueous dipolar aprotic solvents, such as DMF or DMSO, has been investigated.The reaction gave sodium perfluorocarboxylates in 51-86percent yields, and these were transformed to the respective perfluorocarboxylic acids by treatment with sulfuric acid.This provides a new method for the synthesis of perfluorocarboxylic acids.

SYNTHESIS OF PERFLUOROBICYCLIC ETHERS . THE ELECTROCHEMICAL FLUORINATION OF α-CYCLOHEXENYL-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

The electrochemical fluorination of α-cyclohexenyl-substituted carboxylic esters afforded both perfluoro (9-alkyl-7-oxa-bicyclononane)s and perfluoro(8-alkoxy-9-alkyl-7-oxabicyclononane)s in fairly good yields.As the driving force for the ring-closure in this fluorination, a mechanism which involves a resonance stabilized intermediate radical is proposed. Perfluoro(8-chloro-8-methoxy-9-ethyl-7-oxabicyclononane) and perfluoro(8,8-dichloro-9-ethyl-7-oxabicyclononane) were obtained by the controlled chlorination of perfluoro(8-methoxy-9-ethyl-7-oxabicyclo nonane) with anhydrous aluminum chloride in low yields.Some new fused perfluorobicyclic ethers and a perfluoroacid fluoride obtained in this experiment have been characterized by infrared, mass and 19F nmr spectra and elemental analysis.

METAL SILANOLATES: ORGANIC SOLUBLE EQUIVALENTS FOR O-2

Alkali metal trimethylsilanolates, M+ -OSiMe3, convert carboxylic acid derivatives into their corresponding anhydrous acid salts under mild non-aqueous conditions.