18027-10-6

Basic information

• Product Name: SODIUM TRIMETHYLSILANOLATE
• Synonyms: SodiuM odiuM triMethylsilanolate;SodiuM triMethylsilanolate, 1.0 M solution in THF, J&KSeal;SodiuM triMethylsilanolate 95%;SodiuM triMethylsilanolate, 1.0 M solution in THF, HySeal Spc;SODIUM TRIMETHYLSILANOLATE;TRIMETHYLSILANOL, SODIUM SALT;trimethyl-silanosodiumsalt;SODIUM TRIMETHYLSILANOLATE, 1.0M SOLUTIO N IN DICHLOROMETHANE
• CAS NO: 18027-10-6
• Molecular Formula: C₃H₉NaOSi
• Molecular Weight: 112.18
• EINECS: 241-939-8
• Product Categories: Chemical Synthesis;Organic Bases;Synthetic Reagents
• Mol File: 18027-10-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 230 °C (dec.)(lit.)
• Boiling Point: 75 °C at 760 mmHg
• Flash Point: −2 °F
• Appearance: /
• Density: 1.283 g/mL at 25 °C
• BRN: 3912148
• CAS DataBase Reference: SODIUM TRIMETHYLSILANOLATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM TRIMETHYLSILANOLATE(18027-10-6)
• EPA Substance Registry System: SODIUM TRIMETHYLSILANOLATE(18027-10-6)

Safety Data

• Hazard Codes: T,C,F
• Statements: 34-40-23/24/25-20/21/22-19-11-37
• Safety Statements: 26-36/37/39-45-28-27-16
• RIDADR: UN 3267 8/PG 2
• WGK Germany: 3
• F: 3-10-21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 18027-10-6(Hazardous Substances Data)

Usage

Purification Methods

It is very soluble in Et2O and *C6H6 but moderately soluble in pet ether. It is purified by sublimation at 130-150o in a high vacuum. [Hyde et al. J Am Chem Soc 75 5615 1953, Tatlock & Rochow J Org Chem 17 1555 1952, Beilstein 4 III 1856.]

InChI:InChI=1/C3H10OSi.Na/c1-5(2,3)4;/h4H,1-3H3;/q;+1

Upstream product

• 107-46-0 Hexamethyldisiloxane 
• 1825-62-3 ethyl trimethylsilyl ether 
• 1066-40-6 Trimethylsilanol 
• 1825-61-2 Trimethylmethoxysilane 

Downstream Products

• 66128-13-0 trimethylsilyldiphenylphosphine oxide 
• 21001-84-3 (2-bromocyclohexyloxy)trimethylsilane 
• 3555-47-3 1,1,1,5,5,5-hexamethyl-3,3-bis(trimethylsiloxy)trisiloxane 
• 823207-19-8 1-chloro-3,3,3-trimethyl-1-phenyl-disiloxane 
• 823207-23-4 1-chloro-3,3,3-trimethyl-1-(2,4,6-trimethylphenyl)-1-phenyl-disiloxane 
• 378-77-8 sodium pentafluoropropionate 
• 17938-52-2 Diphenylstibino-trimethylsiloxan 
• 2116-84-9 1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane 
• 21907-62-0 Trimethylsiloxy-diphenylwismut 
• 97073-73-9 (triphenylphosphine)3cobalt(I) tirmethylsilanolate 
• 54822-48-9 Pt((C₆H₅)3P)2(OSi(CH₃)3)2 
• 54822-46-7 [Ir(CO)(PPh₃)2(trimethylsiloxy)] 
• 872619-02-8 fac-[Re(CO)3(Ph₂PCH₂CH₂PPh₂)(OSiMe₃)] 

Relevant articles and documents

HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS

Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.

Monosodiumoxyorganoalkoxysilanes: Synthesis and properties

The reaction of organoalkoxysilanes with sodium hydroxide was studied in detail. Studies indicate that this reaction involves more than one stage and involves rather complex multistep process, which leads to the formation of both monosodiumoxyorganoalkoxysilanes (MSOAS) and several secondary products. Analysis of experimental evidence makes it possible to advance the mechanism behind this phenomenon and to define the optimum conditions for the preparation of pure MSOAS with high yields. Different MSOAS were synthesized and their basic physicochemical properties were studied. MSOAS are shown to constitute multifunctional reagents with chemically independent functional groups, and their reaction with trimethylchlorosilane selectively proceeds via - ONa groups, whereas their interaction with triethylesilanol and higher alcohols proceeds exclusively via - OAlk groups. Exchange interaction between MSOAS and organoalkoxysilanes via - ONa and - OAlk groups was found and studied in detail. Temperature corresponding to the onset of thermal degradation of MSOAS was estimated to be equal to ～ 180-190°C.