- Deuterium-modified carbapenem derivatives
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The invention belongs to the technical field of medicines, and particularly relates to deuterium-modified carbapenem derivatives or pharmaceutically acceptable salts thereof, a method for preparing the compounds, pharmaceutical preparations and pharmaceut
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Paragraph 0073-0077
(2021/01/12)
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- Method for preparing amine compound by alkali-catalyzed decarboxylation (by machine translation)
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The method is simple and convenient (reaction conditions ;), more stable,atom utilization rate, by-products are only carbon dioxide pollution, and the yield can reach. suitable for industrial production Curtis; and the method, Lossen is suitable for industrial production . The method disclosed by the invention is simple and convenient to operate under the action of a base as, rearrangement, rearrangement reaction of an alkyl, aryl or heterocyclic aromatic carboxylic acid or an ester and hydroxylamine compound, 90%. (by machine translation)
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- Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates
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A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.
- Li, Peihe,Ma, Nuannuan,Wang, Zheng,Dai, Qipu,Hu, Changwen
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p. 8233 - 8240
(2018/05/31)
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- Alpha-oxidation of amine derivatives by bis(2,2,2-tri-chloroethyl) azodicarboxylate and application of its products as iminium ion equivalents
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Alpha-oxidation of amine derivatives by azodicarboxylate was examined. Among several azodicarboxylate esters and amides tested, bis(2,2,2-trichloroethyl) azodicarboxylate, that has highly electrophilic 2,2,2-trichloroethoxycarbonyl functional groups, was found to have excellent oxidation reactivity. Acylated or carbamoylated amines were suitable substrates for this reaction condition. Tertially amines could react in the same manner, but spontaneous elimination of hydrazinyl group occurred to give dimerized products. The reaction products were found to react with nucleophiles in the presence of Lewis or Br?nsted acid catalyst. This strongly suggests that the reaction products, alpha-hydrazinated amine derivatives, might serve as carbonyl group equivalents, very useful intermediates in synthetic organic chemistry.
- Honzawa, Shinobu,Uchida, Mitsuaki,Tashiro, Takuya,Sugihara, Takumichi
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p. 994 - 1029
(2017/07/27)
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- Electrophilic amination of diorganozinc reagents by oxaziridines
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Electrophilic amination of organozinc reagents by oxaziridines has been studied. Diorganozinc reagents R2Zn (R = alkyl or aryl) react with N-Boc oxaziridine to afford N-Boc protected primary amines BocNHR in moderate to good yields. No additive
- Ghoraf, Mohammed,Vidal, Jo?lle
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scheme or table
p. 7383 - 7385
(2009/05/07)
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- Reductive BOC-amination of aldehydes
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Base-assisted elimination-reduction of α-amidoalkyl sulfones with sodium borohydride proceeds in tetrahydrofuran at room temperature leading to the corresponding BOC-amines in good yields.
- Bernacka, Elbieta,Klepacz, Anna,Zwierzak, Andrzej
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p. 5093 - 5094
(2007/10/03)
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- N-Boc ethyl oxamate: A new nitrogen nucleophile for use in Mitsunobu reactions
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N-Boc ethyl oxamate can be directly coupled with primary and secondary alcohols under Mitsunobu conditions to afford various N-Boc mines after mild deprotection.
- Berree, Fabienne,Michelot, Gwendal,Le Corre, Maurice
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p. 8275 - 8276
(2007/10/03)
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- A New Method for the Synthesis of Amides from Amines: Ruthenium Tetroxide Oxidation of N-Protected Alkylamines
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A simple synthetic method for the preparation of amides from the corresponding primary alkylamines was elaborated using ruthenium tetroxide (RuO4) oxidation as a key step.
- Tanaka, Ken-Ichi,Yoshifuji, Shigeyuki,Nitta, Yoshihiro
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p. 3125 - 3129
(2007/10/02)
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