385405-50-5

Basic information

• Product Name: 1-acetyl-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
• Synonyms: 1-acetyl-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
• CAS NO: 385405-50-5
• Molecular Formula: C₁₇H₁₄BrFN₂O
• Molecular Weight: 361.2082632
• Mol File: 385405-50-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-acetyl-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole(385405-50-5)
• EPA Substance Registry System: 1-acetyl-3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole(385405-50-5)

Safety Data

• Hazardous Substances Data: 385405-50-5(Hazardous Substances Data)

Upstream product

• 98991-32-3 1-(4-bromophenyl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 64-19-7 acetic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1365656-18-3 1-[3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-3-(2-thienyl)-2-propen-1-one 
• 1365656-19-4 1-[3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-3-(4-fluorophenyl)-2-propen-1-one 
• 1365656-20-7 1-[3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-yl]-3-(4-bromophenyl)-2-propen-1-one 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some 3, 5-diaryl-2-pyrazoline derivatives

Eleven new 3-(4-bromophenyl)-5-(4-flirorophenyl)-2-pyrazoline derivatives 4-9 and 11-15 were synthesized by using 1-(4-bromophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (3). The newly synthesized compounds were evaluated for anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compound of this series, 7 was found to be most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.

Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors

Fatty acid biosynthesis is essential for bacterial survival. FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Fifty-six 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and developed as potent inhibitors of FabH. This inhibitor class demonstrates strong antibacterial activity. Escherichia coli FabH inhibitory assay and docking simulation indicated that the compounds 1-(5-(4-fluorophenyl)- 3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (12) and 1-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone (13) were potent inhibitors of E. coli FabH.