38580-22-2

Basic information

• Product Name: ASINEX-REAG BAS 03375399
• Synonyms: CHEMBRDG-BB 4014429;ASINEX-REAG BAS 03375399;ASISCHEM C52011;(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)ACETIC ACID;(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetic acid(SALTDATA: FREE);2-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetic acid
• CAS NO: 38580-22-2
• Molecular Formula: C₇H₈N₂O₄
• Molecular Weight: 184.15
• Mol File: 38580-22-2.mol

Chemical Properties

• Appearance: /
• Density: 1.384g/cm³
• Refractive Index: 1.522
• CAS DataBase Reference: ASINEX-REAG BAS 03375399(CAS DataBase Reference)
• NIST Chemistry Reference: ASINEX-REAG BAS 03375399(38580-22-2)
• EPA Substance Registry System: ASINEX-REAG BAS 03375399(38580-22-2)

Safety Data

• Hazardous Substances Data: 38580-22-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ASINEX-REAG BAS 03375399 is used as a reactant for the preparation of pyrimidine derivatives. These derivatives act as viral replication inhibitors, making them useful in the treatment of HIV infection. By inhibiting the replication of the virus, this compound contributes to the development of antiviral drugs that can help manage and treat HIV in patients.
Used in Chemical Research:
In addition to its pharmaceutical applications, ASINEX-REAG BAS 03375399 can also be utilized in chemical research and development. Its unique structure and properties make it a valuable compound for studying the synthesis and properties of pyrimidine derivatives, which can lead to the discovery of new compounds with potential applications in various industries.
Used in Drug Development:
ASINEX-REAG BAS 03375399 can be employed in the development of new drugs targeting viral infections, particularly HIV. By understanding the mechanism of action of ASINEX-REAG BAS 03375399 and its derivatives, researchers can design and synthesize more effective antiviral medications that can combat drug resistance and improve patient outcomes.

InChI:InChI=1/C7H8N2O4/c1-3-4(2-5(10)11)6(12)9-7(13)8-3/h2H2,1H3,(H,10,11)(H2,8,9,12,13)

Upstream product

• 62214-19-1 (6-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetic acid 
• 10420-33-4 dimethyl 2-acetylsuccinate 
• 626-48-2 6-Methyluracil 
• 64-19-7 acetic acid 

Downstream Products

• 1265396-65-3 methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-71-1 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-77-7 methyl 2-(2-[(S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-83-5 2-(2-((S)-3-(dimethylamino)pyrrolidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-89-1 methyl 2-(2-(4-benzamidopiperidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-94-8 2-(2-(4-benzamidopiperidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-99-3 methyl 2-(2-(4-ethyl-1,4-diazepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265397-04-3 2-(2-(4-ethyl-1,4-diazepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265397-10-1 methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265397-16-7 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265393-19-8 methyl 2-(2-chloro-4-methyl-6-phenylpyrimidin-5-yl)acetate 
• 1265400-31-4 methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate 
• 1265400-41-6 methyl 6,6,6-trifluoro-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)hexanoate 
• 1265400-51-8 methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate 

Relevant articles and documents

NOVEL VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

Free Radical Carboxymethylation of Uracils with Benzoyl Peroxide in Acetic Acid

Acetic acid solutions of the uracils and benzoyl peroxide were heated at 80 deg C to give 5-carboxymethyluracils.Similar treatment of caffeine and benzothiazole gave 8-methylcaffeine and 2-methylbenzothiazole, respectively.