38694-48-3

Basic information

• Product Name: DIETHYLPHOSPHONOBUTANOIC ACID
• Synonyms: DIETHYLPHOSPHONOBUTANOIC ACID;DIETHYL-(3-CARBOXYPROPYL)-PHOSPHONATE;4-(DIETHYLPHOSPHONO)BUTANOIC ACID;4-(Diethylphosphono)butanoic acid, 98 %
• CAS NO: 38694-48-3
• Molecular Formula: C₈H₁₇O₅P
• Molecular Weight: 224.19
• Mol File: 38694-48-3.mol

Chemical Properties

• Melting Point: 62°C
• Boiling Point: 358.7 °C at 760 mmHg
• Flash Point: 170.7 °C
• Appearance: /
• Density: 1.167 g/cm³
• Vapor Pressure: 4.07E-06mmHg at 25°C
• Refractive Index: 1.444
• Sensitive: Hygroscopic
• CAS DataBase Reference: DIETHYLPHOSPHONOBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYLPHOSPHONOBUTANOIC ACID(38694-48-3)
• EPA Substance Registry System: DIETHYLPHOSPHONOBUTANOIC ACID(38694-48-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 38694-48-3(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
DIETHYLPHOSPHONOBUTANOIC ACID is used as a research tool for studying enzyme activity and the development of new pharmaceutical compounds. Its unique structure and properties allow for the investigation of various biological processes and interactions.
Used in Enzyme Inhibition:
DIETHYLPHOSPHONOBUTANOIC ACID is used as an enzyme inhibitor, potentially blocking the activity of specific enzymes involved in various biological pathways. This can be useful in understanding enzyme functions and developing targeted therapies for diseases.
Used in Pharmaceutical Synthesis:
DIETHYLPHOSPHONOBUTANOIC ACID is used as a precursor in the synthesis of pharmacologically active compounds. Its chemical properties enable the creation of new drugs with potential therapeutic benefits.
Used in Agrochemicals:
DIETHYLPHOSPHONOBUTANOIC ACID may have applications in the field of agrochemicals, where its unique properties can be utilized for the development of new pesticides, herbicides, or other agricultural products.
Used in Pharmaceutical Industry:
DIETHYLPHOSPHONOBUTANOIC ACID is used as a starting material for the development of new pharmaceuticals, leveraging its potential to inhibit enzyme activity and its role as a precursor in the synthesis of bioactive compounds. This can lead to the discovery of novel treatments for various diseases and conditions.

InChI:InChI=1/C8H17O5P/c1-3-12-14(11,13-4-2)7-5-6-8(9)10/h3-7H2,1-2H3,(H,9,10)

Upstream product

• 2327-69-7 ethyl 4-(diethoxyphosphoryl)butanoate 
• 96-48-0 4-butanolide 
• 762-04-9 phosphonic acid diethyl ester 
• 64-18-6 formic acid 
• 1067-87-4 Diethyl allylphosphonate 

Downstream Products

• 848487-21-8 (S)-2-{(4E,8E)-2-[2-(Diethoxy-phosphoryl)-ethyl]-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino}-3-phenyl-propionic acid 
• 247229-69-2 diethyl 3-[N-[5-chloro-2-(N-methylcarbamoyl)phenyl]carbamoyl]propylphosphonate 
• 63075-64-9 diethyl (4-hydroxybutyl)phosphonate 
• 2327-75-5 benzyl 4-(diethoxyphosphoryl)butanoate 

Relevant articles and documents

Pd-Catalyzed Highly Chemo- And Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid

An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH is described. A wide variety of linear carboxylic acids bearing various functional groups can be obtained with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.

Synthetic method of terminal carboxylic acid

The invention discloses a synthetic method of a terminal carboxylic acid. The synthetic method is characterized by comprising the steps of adding an olefin represented by a formula (3) shown in the description, formic acid, acetic anhydride, Pd(OAc)2 and a monophosphorus ligand TFPP into an organic solvent in a proportion, carrying out hydrogen carbonylation reaction on the olefin represented by the formula (3) shown in the description, formic acid and acetic anhydride at 80-90 DEG C for 48h-72h under the catalysis of the metal palladium salt Pd(OAc)2 and the monophosphorus ligand TFPP so as to obtain the terminal carboxylic acid represented by a formula shown in the description, and separating a target product, namely the terminal carboxylic acid after the reaction is finished, wherein olefin represented by the formula (3) is selected from cycloolefins, or linear olefins of which the R1 is electron donating groups. By virtue of the method disclosed by the invention, corresponding terminal carboxylic acid and a derivative thereof can be prepared through the reaction under mild conditions of low temperature and no high pressure; and the steps of the synthetic method are simple and convenient, the operation is convenient, the yield is high, the energy source can be greatly saved, and the synthetic efficiency can be greatly improved.

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

A series of eleven double prodrug derivatives of a fosmidomycin surrogate were synthesized and investigated for their ability to inhibit in vitro growth of P. falciparum and M. tuberculosis. A pivaloyloxymethyl (POM) phosphonate prodrug modification was c

AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE

[Problem] To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. [Means for Solution] The present inventors conduct

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Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

Synthesis of new phosphonated tripod ligands as putative new therapeutic agents in the chelation treatment of metal intoxications

In a quest for new chelation therapy drugs for the treatment of intoxication by actinides, some new phosphonated chelating tripod ligands have been synthesized. They have been obtained by means of a coupling reaction between a diethylphosphonoalkanoic acid activated with N,N'-disuccinimidyl carbonate (DSC) and a series of polyamines, with subsequent deprotection of the phosphonate groups.

ACTIVATION ANIONIQUE DU PHOSPHITE DE DIETHYLE PAR LE FLUORURE DE POTASSIUM DEPOSE SUR ALUMINE, SYNTHESE DE PHOSPHONATES FONCTIONALISES

Dry reactions of diethylphosphite on KF-AL2O3 with different electrophiles conduct to the synthesis of functionalized phosphonates.

Organophosphorus Chemistry. IV. Synthesis and Reactions of 2-Ethoxy-6-oxo-1,2-azaphosphinane 2-Oxide

2-Ethoxy-6-oxo-1,2-azophosphinane 2-oxide (3) has been prepared by cyclocondensation of ethyl 4(R-amino-R-ethoxyphosphinoyl)butanoate (17).N-Alkylated derivatives of (3) were prepared by cyclocondensation of (17) in the presence of methyl iodide, allyl br