- Titanyl phthalocyanine and its soluble derivatives: Highly efficient photosensitizers for singlet oxygen production
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The photophysical properties of titanyl phthalocyanine (TiOPc), tetra(β-phenoxy) titanyl phthalocyanine (TiOPc(β-OPh)4) and tetra(α-phenoxy) titanyl phthalocyanine (TiOPc(α-OPh)4), were investigated in homogeneous solution. Absorptio
- Zhang, Xian-Fu,Wang, Yun,Niu, Lihong
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Read Online
- Novel axially substituted lanthanum phthalocyanines: Synthesis, photophysical and nonlinear optical properties
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Materials with excellent nonlinear optical (NLO) properties are usually applied in optoelectronics and optical limiting devices. Photoinduced intramolecular electron transfer (PET) and energy transfer (ET) play an important role in enhanced NLO properties
- Cui, Zengduo,Ding, Jiale,Han, Yuping,Jiang, Zhenhua,Li, Bolong,Zhang, Yunhe
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- Synthesis and structural characterization of Cr(III) complex of porphyrazine and phthalocyanine derivatives: Kinetic studies of metalation and redox activity
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Chromium(III) complexes of 2,3,7,8,12,13,17,18-octakis(propyl)porphyrazine and 2,3,9,10,16,17,23,24-octa substituted phthalocyanine were synthesized, characterized and the kinetics of metalation and redox activity studied and reported. The results obtained indicated that the rate of incorporation of Cr(III) into the central cavity of the ligands is a function of the kinetic inertness and size of the metal ion as well as the peripheral substituents of the ligand. The Cr(III) complex of 2,3,7,8,12,13,17,18-octakis(propyl)porphyrazine exhibited a metal based reduction. Hence it was concluded that the nature of the incorporated metal ions has an influence on the rate and mechanism of incorporation of the metal ion and also the redox activities of these complexes.
- Isabirye, David A.,Seheri, Naledi H.,Aiyelabola, Temitayo O.
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p. 489 - 495
(2017/02/19)
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- Lipophilic N-Hydroxyphthalimide Catalysts for the Aerobic Oxidation of Cumene: Towards Solvent-Free Conditions and Back
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A new class of lipophilic N-hydroxyphthalimide (NHPI) catalysts designed for the aerobic oxidation of cumene in solvent-free conditions was synthesized and tested. The specific strategy proposed for the introduction of lipophilic tails on the NHPI moiety
- Petroselli, Manuel,Melone, Lucio,Cametti, Massimo,Punta, Carlo
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p. 10616 - 10625
(2017/08/09)
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- CRYSTAL TYPES OF COMPOUNDS INHIBITING ACTIVITY OF PROLYL HYDROXYLASE AND USE THEREOF
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The invention relates to crystal types of compound shown as structural formula I, methods of preparing the compound, intermediate, pharmaceutical composition, and use of treating disease or pharmaceutical preparations for treating disease.
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Paragraph 0145; 0147; 0148
(2017/10/27)
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- POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF
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The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder o
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Paragraph 0144
(2015/02/19)
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- Synthesis and structural characterization of 2,3,7,8,12,13,17,18- octakis(propyl), N, N, N′, N′-tetramethylaminoporphyrazines and 2,3,9,10,16,17,23,24-octa substituted phthalocyanine and the kinetic studies of their Co(II) and Cu(II) metalated complexes
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Three tetrapyrrole macrocyclic compounds 2,3,7,8,12,13,17,18- octakis(propyl)porphyrazine, N, N, N′, N′-tetramethylamino porphyrazine hybrid and 2,3,9,10,16,17,23,24-octa substituted phthalocyanine were synthesized and characterized using elemental analys
- Isabirye, David A.,Mtunzi, Fanyana M.,Aiyelabola, Temitayo O.
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p. 214 - 222
(2014/07/07)
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- POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF
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The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder o
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Page/Page column 16
(2013/03/26)
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- Monoamine oxidase inhibition by C4-substituted phthalonitriles
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It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms numerous polar interactions with the polar region of the MAO-B substrate cavity while the C5 side chain extends to, and interacts via Van der Waals interactions with the hydrophobic regions of the enzyme entrance cavity. Interactions with both cavities appear to be requirements for high affinity binding. In the present study we have examined an analogs series of C4-substituted phthalonitriles as potential human MAO inhibitors. The phthalonitriles were found to be highly potent reversible MAO-B inhibitors with most analogs exhibiting IC50 values in the low nM range. The phthalonitriles also interacted with human MAO-A, although with lower binding affinities compared to MAO-B. Modeling studies suggest that the high binding affinities of the phthalonitriles to MAO-B may depend, at least in part, on the formation of polar interactions between the nitrile functional groups and the enzyme substrate cavity. Examination of a homologs series of benzonitriles established that the phthalonitrile moiety is more optimal for MAO-B inhibition than the corresponding benzonitrile moiety, and that C3-substituted benzonitriles are better MAO-B inhibitors than C4-substituted benzonitriles. Since elimination of the nitrile functional group yielded compounds with only moderate MAO-B inhibition potencies, it may be concluded that this functional group is privileged for MAO-B inhibition.
- Manley-King, Clarina I.,Bergh, Jacobus J.,Petzer, Jacobus P.
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experimental part
p. 114 - 124
(2012/03/27)
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- Physico-chemical properties of lutetium phthalocyanine complexes in solution and in solid polystyrene polymer fibers and their application in photoconversion of 4-nitrophenol
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The photophysical and photochemical behavior of two phthalocyanine complexes of lutetium peripherally substituted with tetraphenoxy and tetra-2-pyridiloxy groups were studied in solution and when dispersed in polystyrene polymer fiber. The phthalocyanines were found not to fluoresce significantly in solution and not at all within the fiber matrix as compared with standard unsubstituted zinc phthalocyanine. They showed very promising photoactivity in solution with high singlet oxygen quantum yields. Their photoactivity within the polymer fiber matrix was also demonstrated with the photoconversion of 4-nitrophenol, a water pollutant. The photodegradation process with both phthalocyanines follows first order kinetics similar to that observed for the zinc phthalocyanine and the photo-products were found to be hydroquinone, benzoquinone and 4-nitrocatechol.
- Zugle, Ruphino,Nyokong, Tebello
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scheme or table
p. 49 - 57
(2012/06/16)
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- Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
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Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding affinity to both MAO isozymes compared to isatin and in most instances result in selective binding to the MAO-B isoform. Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond interactions between the NH and the C2 carbonyl oxygen of the dioxoindolyl moiety and water molecules present in the substrate cavities of MAO-A and -B. Based on these observations and the close structural resemblances between isatin and its phthalimide isomer, a series of phthalimide analogues were synthesized and evaluated as MAO inhibitors. While phthalimide and N-aryl-substituted phthalimides were found to be weak MAO inhibitors, phthalimide homologues containing C5 substituents were potent reversible inhibitors of recombinant human MAO-B with IC50 values ranging from 0.007 to 2.5 μM and moderately potent reversible inhibitors of recombinant human MAO-A with IC50 values ranging from 0.22 to 9.0 μM. By employing molecular docking the importance of hydrogen bonding between the active sites of MAO-A and -B and the phthalimide inhibitors are highlighted.
- Manley-King, Clarina I.,Bergh, Jacobus J.,Petzer, Jacobus P.
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body text
p. 4829 - 4840
(2011/09/20)
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- Synthesis, photophysical and photochemical properties of aryloxy tetra-substituted gallium and indium phthalocyanine derivatives
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The synthesis, photophysical and photochemical properties of the tetra-substituted aryloxy gallium(III) and indium(III) phthalocyanines are reported for the first time. General trends are described for photodegradation, singlet oxygen, fluorescence, and t
- Durmu?, Mahmut,Nyokong, Tebello
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p. 1385 - 1394
(2007/10/03)
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- 4-Tetraphenyl- and 4-tetraphenoxy-substituted meso- tetraphenyltetrabenzoporphyrins. Synthesis and spectral properties
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The reactions of 4-phenyl- and 4-phenoxyphthalimide with benzoic acid in the presence of zinc(II) oxide gave zinc complexes of meso-tetraphenyltetra(4- phenylbenzo)porphyrin and meso-tetraphenyltetra-(4-phenoxybenzo)porphyrin, respectively, and the latter
- Galanin,Kudrik,Shaposhnikov
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p. 603 - 606
(2007/10/03)
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- Poly-substituted phthalocyanines
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The use of substituted phthalocyanines for the generation of singlet oxygen in which at least one of the peripheral carbon atoms in the 1-16 positions of the phthalocyanine nucleus (Mk Pc) of Formula (1): STR1 wherein: M is selected from H, met
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- SUBSTITUTION OF THE NITRO GROUP IN 4-NITROPHTHALONITRILE WITH THE PHENOL-METAL CARBONATE SYSTEM AS NUCLEOPHILE
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Substitution of the nitro group in 4-nitrophthalonitrile by an aryloxy group under the influence of the phenol-metal carbonate system in DMFA apparently takes place at the surface of the carbonate, and the controlling stage is deprotonation of the phenol.
- Kaninskii, P. S.,Abramov, I. G.,Yasinskii, O. A.,Mironov, G. S.,Plakhtinskii, V. V.
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p. 964 - 967
(2007/10/02)
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- Poly(oxyalkylene) modified phthalocyanine colorants
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A colorant for natural or synthetic resinous or polymeric materials, having the formula: wherein; R2 is selected from hydrogen, methyl, cyclohexyl, phenyl or Y; A is a nonionic metallophthalocyanine chromophore which can be substituted for example with halogen, alkyl, alkoxy, alkylthio, or aryloxy; Z is an arylene moiety; D is a linking group being or containing at least one of --O--, --S--, --SO2 --, --N(R3)--, or --N(SO2 R4)-- as the linking moiety, wherein R4 is unsubstituted or substituted alkyl, cycloalkyl or aryl, and R3 is R4 or hydrogen; Y is a poly(oxyalkylene) moiety containing at least three monomeric units of the formula (--RO--) wherein each R is straight or branched alkylene of 1-4 carbons or mixtures thereof, up to about 20 mole percent of said monomeric units may be connected by one or more linking groups such as alkyleneoxy, --NH--, or --NHCONH--, and wherein Y can be terminated by hydrogen, or by or contain as branch substituents, 1-3 groups or moieties selected from alkyl, cycloalkyl, acyl, or aryl; wherein any of the above recited hydrocarbon groups, moieties or substituents may themselves be substituted with up to four substituents selected, for example, from alkyl, halogen, mercapto, alkoxycarbonyl, hydroxy, alkoxy, or the like; and wherein each aliphatic hydrocarbon portion or moiety of the groups, moieties or substituents recited above contains from 1-20 carbons.
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