394223-19-9

Basic information

• Product Name: METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE
• Synonyms: Methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate, 2-(Methoxycarbonyl)-1H-pyrrolo[3,2-b]pyridine;METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE;Methyl 4-azaindole-2-carboxylate;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, Methyl ester
• CAS NO: 394223-19-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.18
• Mol File: 394223-19-9.mol

Chemical Properties

• Melting Point: 141-143℃
• Boiling Point: 347.469°C at 760 mmHg
• Flash Point: 163.943°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• PKA: 12.63±0.40(Predicted)
• CAS DataBase Reference: METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE(394223-19-9)
• EPA Substance Registry System: METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE(394223-19-9)

Safety Data

• Hazardous Substances Data: 394223-19-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE is used as a synthetic intermediate for the development of various drugs due to its unique core structure and potential biological activities. Its presence in drug molecules can contribute to their therapeutic effects and pharmacological properties.
Used in Chemical Research:
In the field of chemical research, METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE serves as a valuable component in the synthesis of complex organic molecules. Its versatile structure allows for the exploration of new chemical pathways and the creation of novel compounds with potential applications in various industries.
Safety Precautions:
It is crucial to handle METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE with appropriate safety measures, as it may pose health hazards if not properly managed. Adequate protective equipment and handling procedures should be followed to minimize risks associated with its use.

InChI:InChI=1/C9H8N2O2/c1-13-9(12)8-5-7-6(11-8)3-2-4-10-7/h2-5,11H,1H3

Upstream product

• 17288-35-6 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 17288-32-3 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 17288-52-7 1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde 

Relevant articles and documents

INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

Chemical development of the casein kinase i - Epsilon inhibitor: 3-(3-fluorophenyl)sulfanyl-1 H -pyrrolo[3,2- b pyridine-2-carboxylic acid amide

The development of a scalable process for 3-arylsulfanyl-1H-pyrrolo[3,2- bpyridine-2-carboxylic acid amides (1), potent casein kinase I inhibitors, is described. The rapid identification of suitable reaction conditions expedited the lab scale synthesis of drug substances for early toxicological evaluations. Further improvements were made to achieve a safe and cost-effective process to meet increasing demands for drug substances to support clinical studies. This paper describes the synthesis at multikilogram scale.

Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon

The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.