METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE
• CAS No.: 394223-19-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17200
• Hs Code.: 2933990090
• Mol file: 394223-19-9.mol

Synonyms:Methyl 4-azaindole-2-carboxylate;Methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate;

Chemical Property of METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 141-143℃
• Boiling Point: 347.469oC at 760 mmHg
• PKA: 12.63±0.40(Predicted)
• Flash Point: 163.943oC
• PSA: 54.98000
• Density: 1.325g/cm3
• LogP: 1.34950

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-azaindole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE

There total 3 articles about METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester (17288-32-3) → methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (394223-19-9)

Guidance literature:

With potassium carbonate; at 55 ℃; for 1h;

Reference yield: 60.0%

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (17288-35-6) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (394223-19-9)

Guidance literature:

In hexane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

methanol (67-56-1) + 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester (17288-32-3) → methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (394223-19-9) + 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid amide (853685-35-5) + 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (17288-35-6)

Guidance literature:

With ammonia; at 50 ℃; for 36h;

DOI:10.1021/op200171a

upstream raw materials:

methanol

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde

Refernces

• 1、 Huang, Bao-Guo,Kubiak, Gregory,Shay, John J.,Pemberton, Clive,Peers, James,Hanna, Reda G.,Powers, Matthew R.,Gamboa, Juan A.,Gelormini, Ann M.,Yarabe, Hyacinthe,Rudisill, Duane E.. "Chemical development of the casein kinase i - Epsilon inhibitor: 3-(3-fluorophenyl)sulfanyl-1 H -pyrrolo[3,2- b pyridine-2-carboxylic acid amide". body text. p. 1040 - 1045. Retrieved 2011/12/21.