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6-Phenylpyridine-2-carboxylic acid is an organic compound with the molecular formula C15H11NO2. It is a derivative of pyridine, featuring a phenyl group attached to the 6th position and a carboxylic acid group at the 2nd position. 6-Phenylpyridine-2-carboxylic acid is known for its potential applications in various fields due to its unique chemical structure and properties.

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  • 39774-28-2 Structure
  • Basic information

    1. Product Name: 6-Phenylpyridine-2-carboxylic acid
    2. Synonyms: 6-PHENYLPYRIDINE-2-CARBOXYLIC ACID, 98+%;6-Benzyl-2-pyridinecarboxylic acid;6-Phenylpicolinic acid, 2-Carboxy-6-phenylpyridine;6-PHENYLPICOLINIC ACID;6-PHENYLPYRIDINE-2-CARBOXYLIC ACID;6-PHENYL-2-PYRIDINECARBOXYLIC ACID;2-PHENYL-6-PYRIDINE CARBOXYLIC ACID
    3. CAS NO:39774-28-2
    4. Molecular Formula: C12H9NO2
    5. Molecular Weight: 199.21
    6. EINECS: N/A
    7. Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids;fine chemicals, specialty chemical, Carboxylic Acidss, intermediates, electronic chemical, organic synthesis;Heterocycle-Pyridine series
    8. Mol File: 39774-28-2.mol
  • Chemical Properties

    1. Melting Point: 107.0 to 111.0 °C
    2. Boiling Point: 408.979 °C at 760 mmHg
    3. Flash Point: 201.143 °C
    4. Appearance: /
    5. Density: 1.241 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.613
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: DMSO (Slightly), Methanol (Slightly)
    10. PKA: 4.60±0.10(Predicted)
    11. CAS DataBase Reference: 6-Phenylpyridine-2-carboxylic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Phenylpyridine-2-carboxylic acid(39774-28-2)
    13. EPA Substance Registry System: 6-Phenylpyridine-2-carboxylic acid(39774-28-2)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 39774-28-2(Hazardous Substances Data)

39774-28-2 Usage

Uses

Used in Pharmaceutical Industry:
6-Phenylpyridine-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a building block for the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
In the field of chemical research, 6-Phenylpyridine-2-carboxylic acid serves as a valuable compound for studying the properties and reactivity of pyridine derivatives. It can be used to explore new reaction pathways and develop novel synthetic methods.
Used in the Preparation of Inhibitors:
6-Phenylpyridine-2-carboxylic acid is used in the preparation of inhibitors acting upon 2-Oxoglutarate-dependent nucleic acid demethylase. This enzyme plays a crucial role in nucleic acid repairs and modifications, and its inhibition can have significant implications in the treatment of certain diseases and conditions related to nucleic acid regulation.

Check Digit Verification of cas no

The CAS Registry Mumber 39774-28-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,7,7 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 39774-28:
(7*3)+(6*9)+(5*7)+(4*7)+(3*4)+(2*2)+(1*8)=162
162 % 10 = 2
So 39774-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H9NO2/c14-12(15)11-8-4-7-10(13-11)9-5-2-1-3-6-9/h1-8H,(H,14,15)

39774-28-2 Well-known Company Product Price

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  • TCI America

  • (P2320)  6-Phenylpyridine-2-carboxylic Acid  >98.0%(GC)(T)

  • 39774-28-2

  • 1g

  • 1,390.00CNY

  • Detail
  • TCI America

  • (P2320)  6-Phenylpyridine-2-carboxylic Acid  >98.0%(GC)(T)

  • 39774-28-2

  • 5g

  • 6,500.00CNY

  • Detail

39774-28-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Phenylpyridine-2-Carboxylic Acid

1.2 Other means of identification

Product number -
Other names 6-Phenylpicolinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:39774-28-2 SDS

39774-28-2Relevant articles and documents

Conversion from arenes having a benzene ring to those having a picolinic acid by simple growing cell reactions using Escherichia coli that expressed the six bacterial genes involved in biphenyl catabolism

Shindo, Kazutoshi,Osawa, Ayako,Nakamura, Ryoko,Kagiyama, Yukiko,Sakuda, Shohei,Shizuri, Yoshikazu,Furukawa, Kensuke,Misawa, Norihiko

, p. 15042 - 15043 (2004)

The comprehensive bioconversion of aromatic compounds with a benzene ring to a picolinic acid was achieved with a recombinant Escherichia coli strain that expressed the six genes involved in biphenyl catabolism, these being the bphA1(2072)A2A3A4 genes encoding the evolved biphenyl dioxygenase, the bphB gene encoding dihydrodiol dehydrogenase, and the bphC gene encoding catechol 2,3-dioxygenase. Copyright

New class of NCS-free cyclometalated ruthenium(II) complexes with 6-phenylpyridine-2-carboxylate for use as near-infrared sensitizers in dye-sensitized solar cells

Funaki, Takashi,Otsuka, Hiromi,Onozawa-Komatsuzaki, Nobuko,Kasuga, Kazuyuki,Sayama, Kazuhiro,Sugihara, Hideki

, p. 137 - 139 (2014/06/24)

Three examples, FT102, FT90, and FT117 of a new class of NCS-free cyclometalated ruthenium(II) complexes, Ru(tctpy)(O^N^C) (where O^N^C is a tridentate 6-phenylpyridine-2-carboxylate), were synthesized for use as near-infrared (IR) sensitizers in dye-sensitized solar cells (DSSCs). A tridentate donor ligand, 6-phenylpyridine-2-carboxylate was introduced in order to enhance the light harvesting efficiency in the longer wavelength region for the first time. Modifying the ligand improved the photovoltaic performance, and DSSCs sensitized with FT117 exhibited efficient panchromatic sensitization over the entire visible wavelength, extending into the near-IR region. The highest incident photon-to-current conversion efficiency (68%) was found at 600 nm, and the action spectrum onset was near 920 nm.

2-AMINOCARBONYL-PYRIDINE DERIVATIVES

-

Page/Page column 109-110, (2008/06/13)

The present invention relates to 2-aminocarbonyl-pyridine derivatives and their use as P2Yi2 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Discovery of pyrrolopyridine-pyridone based inhibitors of met kinase: Synthesis, X-ray crystallographic analysis, and biological activities

Kyoung, Soon Kim,Zhang, Liping,Schmidt, Robert,Cai, Zhen-Wei,Wei, Donna,Williams, David K.,Lombardo, Louis J.,Trainor, George L.,Xie, Dianlin,Zhang, Yaquan,An, Yongmi,Sack, John S.,Tokarski, John S.,Darienzo, Celia,Kamath, Amrita,Marathe, Punit,Zhang, Yueping,Lippy, Jonathan,Jeyaseelan Sr., Robert,Wautlet, Barri,Henley, Benjamin,Gullo-Brown, Johnni,Manne, Veeraswamy,Hunt, John T.,Fargnoli, Joseph,Borzilleri, Robert M.

experimental part, p. 5330 - 5341 (2009/07/01)

Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to potent 4-pyridone and pyridine N-oxide inhibitors such as 3 and 4. The X-ray crystallographic data of the inhibitor 2 bound to the ATP binding site of Met kinase protein provided insight into the binding modes of these inhibitors, and the SAR of this series of analogues was rationalized. Many of these analogues showed potent antiproliferative activities against the Met dependent GTL-16 gastric carcinoma cell line. Compound 2 also inhibited Flt-3 and VEGFR-2 kinases with IC50 values of 4 and 27 nM, respectively. It possesses a favorable pharmacokinetic profile in mice and demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model.

A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition.

Malkov, Andrei V,Hand, John B,Kocovsky, Pavel

, p. 1948 - 1949 (2007/10/03)

New N,P-ligands 4-6, derived from valinol and prolinol, respectively, have been developed for the asymmetric, copper(I)-catalysed conjugate addition of diethylzinc to unsaturated ketones; the tertiary amide group has been shown to effectively relay the chiral information from the ligand backbone to the active centre.

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