39891-04-8

Basic information

• Product Name: 3-FLUORO-5-FORMYLPYRIDINE
• Synonyms: 5-FLUOROPYRIDINE-3-CARBALDEHYDE;3-PYRIDINECARBOXALDEHYDE, 5-FLUORO-;3-FLUORO-5-FORMYLPYRIDINE;3-Fluoropyridine-5-carboxaldehyde;3-Pyridinecarboxaldehyde,5-fluoro-(9CI);5-Fluoronicotinaldehyde;3-fluorine-5-formylpyridine;5-Fluoropyridine-3-carboxaldehyde, 5-Fluoro-3-formylpyridine, 3-Fluoro-5-formylpyridine, 3-Fluoropyridine-5-carboxaldehyde
• CAS NO: 39891-04-8
• Molecular Formula: C₆H₄FNO
• Molecular Weight: 125.1
• EINECS: 206-914-8
• Product Categories: PYRIDINE;pharmacetical;Aldehyde;Building Blocks;Pyridines;Fluorine series;organic building block
• Mol File: 39891-04-8.mol

Chemical Properties

• Boiling Point: 189℃
• Flash Point: 68℃
• Appearance: /
• Density: 1.269
• Vapor Pressure: 0.0362mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.01±0.20(Predicted)
• CAS DataBase Reference: 3-FLUORO-5-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-FORMYLPYRIDINE(39891-04-8)
• EPA Substance Registry System: 3-FLUORO-5-FORMYLPYRIDINE(39891-04-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 39891-04-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-5-formylpyridine is utilized as an intermediate in the synthesis of various active pharmaceutical ingredients. Its distinctive structure and reactivity contribute to the development of new drugs, enhancing the therapeutic potential of medications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-fluoro-5-formylpyridine serves as a key component in the creation of novel pesticides. Its chemical properties allow for the design of effective and targeted pest control agents.
Used in Medicinal Chemistry and Drug Discovery:
3-Fluoro-5-formylpyridine is also being explored for its potential applications in medicinal chemistry and drug discovery. Its unique attributes make it a promising candidate for the advancement of new therapeutic agents and the improvement of existing ones.

InChI:InChI=1/C9H6F3NS/c1-5-13-7-4-6(9(10,11)12)2-3-8(7)14-5/h2-4H,1H3

Upstream product

• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 107756-01-4 C₁₃H₁₂FN₃O₃S 
• 701-40-6 5-fluoropyridine-3-carbohydrazide 
• 22620-29-7 Ethyl 5-fluoronicotinate 
• 591-22-0 3,5-Lutidine 
• 407-21-6 5-methyl-3-fluoropyridine 
• 3430-19-1 5-methylpyridin-3-amine 
• 3222-49-9 5-methylnicotinic acid 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 884494-95-5 5-methyl-nicotinic acid chloride 
• 70-57-5 5-methylpyridinylcarboxamide 
• 455-70-9 5-fluoro-3-pyridinecarboxylic acid methyl ester 

Downstream Products

• 114995-63-0 (2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone 
• 118420-35-2 N-[3-(5-fluoro-pyridin-3-yl)acryloyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine 
• 1029052-71-8 [5-((1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-4-chloro-thiazol-2-yl]-(5-fluoro-pyridin-3-ylmethyl)-amine 
• 1029052-76-3 [5-((1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-pyridin-2-yl]-(5-fluoro-pyridin-3-ylmethyl)-amine 
• 1062205-01-9 [3-(9-{1-[(5-fluoropyridin-3-yl)methyl]piperidin-4-yl}-6-morpholin-4-yl-9H-purin-2-yl)phenyl]methanol 
• 1198353-49-9 5-fluoronicotinaldehyde oxime 
• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 1426899-73-1 2-(5-fluoro-pyridin-3-yl)-6-hydroxy-chroman-4-one 
• 1426899-72-0 (E)-1-(2,5-dihydroxy-phenyl)-3-(5-fluoro-pyridin-3-yl)propenone 
• 1448520-29-3 4-(5-fluoropyridin-3-yl)-4-hydroxy-1-(1-(4-isopropoxy-3-methylbenzoyl)piperidin-4-ylidene)butan-2-one 
• 1426388-99-9 4-(2-(4-(5-fluoropyridin-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile 
• 2205871-61-8 6-chloro-3-[3-(5-fluoropyridin-3-yl)acryloyl]-4-phenyl-1H-quinolin-2-one 
• 1095380-97-4 (4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine 
• 1095381-12-6 (4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine 

Relevant articles and documents

PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.

Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same

The present invention relates to novel pyridine compounds having antiallergic activity mainly through 5-lipoxygenase inhibitory activity, antihistamine activity and/or inhibiting activity against chemical mediator release

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.

A General Synthesis of Substituted Fluorenones and Azafluorenones

Twenty-one variously substituted fluorenones and azafluorenones have been synthesized via photochemical Pschorr cyclizations of 2-diazoniodiaryl ketones as the key ring-forming step.Direct, (bipy)3RuII-, or (bipy)3RuII/CuII-photosensitized conditions were used, depending on the system to be cyclized.Where selectivities were possible in the ring closure, the isomer ratios obtained were in accord with an aryl radical as the reactive intermediate.The precursor aminodiaryl ketones were obtained from the sequence ortho lithiation of an arylpivalamide, reaction withan aryl aldehyde to give a 2-pivalamidodiarylcarbinol, oxidation to give a 2-pivalamidodiaryl ketone, and hydrolysis to give the 2-aminodiaryl ketone.