42088-91-5

Basic information

• Product Name: 1-PYRIDIN-2-YL-ETHYLAMINE
• Synonyms: 1-PYRIDIN-2-YL-ETHYLAMINE;1-(2-Pyridyl)ethylamine;2-(1-Aminoethyl)pyridine;1-Pyridin-2-yl-ethylamine oxalate;1-(2-Pyridyl)ethaneamine;1-(2-Pyridinyl)ethylamine;1-Pyridine-2-yl-ethylamine;2-Pyridinemethanamine, .alpha.-methyl-
• CAS NO: 42088-91-5
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Product Categories: pharmacetical
• Mol File: 42088-91-5.mol

Chemical Properties

• Boiling Point: 194.5 °C at 760 mmHg
• Flash Point: 78℃
• Appearance: /
• Density: 1.002 g/mL at 25 °C
• Vapor Pressure: 0.44mmHg at 25°C
• Refractive Index: n20/D1.528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.05±0.39(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-PYRIDIN-2-YL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PYRIDIN-2-YL-ETHYLAMINE(42088-91-5)
• EPA Substance Registry System: 1-PYRIDIN-2-YL-ETHYLAMINE(42088-91-5)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-37/38-41
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2735
• WGK Germany: nwg
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 42088-91-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Pyridin-2-yl-ethylamine is used as a precursor in the synthesis of various pharmaceuticals and biologically active compounds, leveraging its ability to modulate neurotransmitter levels in the brain for potential therapeutic benefits.
Used in Central Nervous System Applications:
In the field of neuroscience, 1-Pyridin-2-yl-ethylamine is utilized for its potential therapeutic effects on the central nervous system, where it can influence neurotransmitter levels, offering possible treatments for neurological conditions.
Used in Psychoactive Drug Development:
Due to its psychoactive properties, 1-Pyridin-2-yl-ethylamine is used in the development of stimulant drugs, contributing to the advancement of medications targeting cognitive function and mood regulation.
Used in Agricultural Chemical Production:
1-Pyridin-2-yl-ethylamine is employed as a key component in the production of agricultural chemicals, where it may contribute to the development of more effective and targeted crop protection agents.
Used in Dyes and Pigments Industry:
In the dyes and pigments industry, 1-Pyridin-2-yl-ethylamine is used for its ability to create a range of colors and shades, enhancing the variety and quality of products available for various applications.

InChI:InChI=1/C7H10N2/c1-6(8)7-4-2-3-5-9-7/h2-6H,8H2,1H3/p+1/t6-/m1/s1

Upstream product

• 1122-62-9 2-acetylpyridine 
• 110-60-1 1,4-diaminobutane 
• 87227-77-8 bishydrochloride salt of cis-1,4-diamino-but-2-ene 

Downstream Products

• 1013624-57-1 C₁₄H₁₄N₂O₂ 
• 689177-81-9 4-nitro-N-[1-(2-pyridinyl)ethyl]benzamide 
• 115519-41-0 5-[4-(1,1-dimethylethyl)phenoxy]-2,2-dimethyl-N-[1-(2-pyridinyl)ethyl]pentanamide 
• 115519-43-2 5-(4-hexylphenoxy)-2,2-dimethyl-N-[1-(2-pyridinyl)ethyl]pentanamide 
• 115519-39-6 2,2-dimethyl-5-(4-methylphenoxy)-N-[1-(2-pyridinyl)ethyl]pentanamide 
• 515160-13-1 (C₄H₂NC(C₆H₅))3C₄H₂NC(C₆H₄NHC(O)C₅H₃NC(O)NHCH(CH₃)C₅H₄N)Zn 
• 1038281-69-4 2-((1-(2-pyridyl)ethylamino)methyl)phenol 
• 580-35-8 2,4,6-triphenylpyridine 
• 854701-06-7 N-[((1-pyridin-2-yl)ethyl)]formamide 

Relevant articles and documents

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.

But-2-ene-1,4-diamine and But-2-ene-1,4-diol as Donors for Thermodynamically Favored Transaminase- and Alcohol Dehydrogenase-Catalyzed Processes

Both cis- and trans-but-2-ene-1,4-diamines have been prepared and efficiently applied as sacrificial cosubstrates in enzymatic transamination reactions. The best results were obtained with the cis-diamine. The thermodynamic equilibrium of the stereoselective transamination process is shifted to the amine formation due to tautomerization of 5H-pyrrole into 1H-pyrrole, achieving high conversions (78–99%) and enantiomeric excess (up to >99%) by using a small excess of the amine donor. Furthermore, when the reaction proceeded, a strong coloration was observed due to polymerization of 1H-pyrrole. A structurally related compound, cis-but-2-ene-1,4-diol, has been utilized as cosubstrate in different alcohol dehydrogenase (ADH)-mediated bioreductions. In this case, high conversions (91–99%) were observed due to a lactonization process. Both strategies are convenient from both synthetic and atom economy points of view in the production of valuable optically active products. (Figure presented.).

Voltammetric, potentiometric and spectrophotometric studies of some hydrazones and their metal complexes in ethanolic-aqueous buffered solutions

The electrochemical behavior of some hydrazones derived from 6-chloro-2-hydrazinopyridine in the Britton-Robinson universal buffer of pH 2-11 containing 35% ethanol was investigated at the mercury electrode using dc-polarography, controlled-potential coulometry, and cyclic voltammetry techniques. The examined hydrazones were reduced in solutions of pH 2 single bond. The mechanistic pathway of the electrode reaction of the studied compounds was elucidated and discussed. The pK a values of the examined hydrazones and the stoichiometry of their complexes in solution with some transition metal ions were determined spectrophotometrically. The dissociation constants and the thermodynamic parameters of the investigated hydrazones, and the stability constants of their metal complexes in solution were determined potentiometrically. Springer-Verlag 2006.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.