42263-75-2

Basic information

• Product Name: 5-methoxy-1-methyl-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 42263-75-2
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.2384
• Mol File: 42263-75-2.mol

Chemical Properties

• Boiling Point: 321.6°C at 760 mmHg
• Flash Point: 146.3°C
• Density: 1.076g/cm³
• Vapor Pressure: 0.000295mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 5-methoxy-1-methyl-3,4-dihydronaphthalen-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-1-methyl-3,4-dihydronaphthalen-2(1H)-one(42263-75-2)
• EPA Substance Registry System: 5-methoxy-1-methyl-3,4-dihydronaphthalen-2(1H)-one(42263-75-2)

Safety Data

• Hazardous Substances Data: 42263-75-2(Hazardous Substances Data)

Upstream product

• 32940-15-1 5-methoxy-2-tetralone 
• 90295-47-9 1,2-dihydro-4-methyl-8-methoxynaphthalene 
• 73739-49-8 5-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydronaphthalin-1-thiocarbonsaeuremethylester 
• 74-88-4 methyl iodide 
• 105372-18-7 1,2,3,4-tetrahydro-1,2-methano-2,5-dimethoxynaphthalene 
• 77-78-1 dimethyl sulfate 
• 575-44-0 1,6-dihydroxynaphthalene 
• 33892-75-0 5-Methoxy-1-tetralone 
• 73067-20-6 5-Methoxy-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carbothioic acid S-methyl ester 
• 6099-03-2 3-(2'-methoxyphenyl)propenoic acid 

Downstream Products

• 79548-61-1 (3bR,9bS)-6-hydroxy-7-isopropyl-9b-methyl-3b,4,10,11-tetrahydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione 
• 5095-09-0 (+/-)-Δ¹⁶-Kauren-19-saeure 
• 90295-51-5 (+/-)-trans-5-methoxy-1-methyl-2-(α-propylamino)tetralin 
• 95999-15-8 (-)-cis-5-methoxy-1-methyl-2-<(1-phenylethyl)amino>tetralin 
• 95999-17-0 (1S,2R,αR)-cis-5-methoxy-2-<(α-phenylethyl)amino>tetralin 
• 5720-82-1 8-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-2-one 
• 120303-35-7 (5-Methoxy-1-methyl-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 

Relevant articles and documents

Synthesis of 2-tetralone derivatives by Bi(OTf)3-catalyzed intramolecular hydroarylation/isomerization of propargyl alcohols

Compared to 1-tetralones, 2-tetralones are expensive, less stable, and difficult to synthesize. A concise Bi-catalyzed method was developed for the synthesis of 2-tetralones from 5-phenylpent-1-yn-3-ol derivatives. Diverse 2-tetralones were obtained in moderate to good yields under mild conditions.

PREPARATION METHOD OF 2-TETRALONE DERIVATIVES CATALYZED BY BISMUTH/SILVER MIXED SALTS

The present invention relates to a method for preparing a 2-tetralone derivative using a bismuth/silver mixed catalyst in a simple and efficient manner. According to the method, a target material can be obtained within short time as the bismuth/silver mixed catalyst is used. The 2-tetralone derivative, prepared by the method, can be used to synthesize pharmaceutical products and intermediates of natural materials. The 2-tetralone derivative is represented by Chemical formula 1.COPYRIGHT KIPO 2015

An unexpected double-bond isomerization catalyzed by Crabtree's iridium(I) catalyst

The first iridium-catalyzed isomerization of an exocyclic into an endocyclic double bond is described. A mechanism is proposed for this reaction. Crabtree's catalyst thus allows the migration of a double bond that does not occur under classical conditions. Georg Thieme Verlag Stuttgart.

ENANTIOSELECTIVE PREPARATION OF KEY INTERMEDIATES FOR STEROID SYNTHESIS THROUGH THE ASYMMETRIC MICHAEL ADDITION PROCESS INVOLVING CHIRAL IMINES.

(S)-Phenanthrone 7, prepared from ketone 4 (80 percent yield, 93 percent ee), was transformed into compounds 8, 9, 13, 15 and 16, useful intermediates in steroid synthesis.

Syntheses of 5-, 7-, and 8-Methoxy-3-methyl-2-tetralone

Two efficient syntheses of 5-methoxy- and 8-methoxy-3-methyl-2-tetralone and the synthesis of the 7-methoxy isomer via a different route are described.Also reported is the synthesis of 8-methoxy-3,3-dimethyl-2-tetralone.The regioselectivity of lithium carbanion formation in 1,6-, 1,7-, and 2,7-dihydroxynaphthalene is discussed.The latter compound undergoes dimetalation more easily than the other isomers.

Benzobicycloalkane ketones

Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.

Benzobicycloalkanone oximes

Benzobicycloalkanone oximes which are intermediates for the preparation of benzobicycloalkane amines. The amines exert analgesic and antiinflammatory effects in warm-blooded animals.