- Synthesis of 2-tetralone derivatives by Bi(OTf)3-catalyzed intramolecular hydroarylation/isomerization of propargyl alcohols
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Compared to 1-tetralones, 2-tetralones are expensive, less stable, and difficult to synthesize. A concise Bi-catalyzed method was developed for the synthesis of 2-tetralones from 5-phenylpent-1-yn-3-ol derivatives. Diverse 2-tetralones were obtained in moderate to good yields under mild conditions.
- Yun, Jihee,Park, Jungmin,Kim, Jaehyun,Lee, Kooyeon
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p. 1045 - 1048
(2015/02/19)
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- PREPARATION METHOD OF 2-TETRALONE DERIVATIVES CATALYZED BY BISMUTH/SILVER MIXED SALTS
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The present invention relates to a method for preparing a 2-tetralone derivative using a bismuth/silver mixed catalyst in a simple and efficient manner. According to the method, a target material can be obtained within short time as the bismuth/silver mixed catalyst is used. The 2-tetralone derivative, prepared by the method, can be used to synthesize pharmaceutical products and intermediates of natural materials. The 2-tetralone derivative is represented by Chemical formula 1.COPYRIGHT KIPO 2015
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Paragraph 0072; 0073; 0074; 0075
(2016/10/17)
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- An unexpected double-bond isomerization catalyzed by Crabtree's iridium(I) catalyst
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The first iridium-catalyzed isomerization of an exocyclic into an endocyclic double bond is described. A mechanism is proposed for this reaction. Crabtree's catalyst thus allows the migration of a double bond that does not occur under classical conditions. Georg Thieme Verlag Stuttgart.
- Krel, Michael,Lallemand, Jean-Yves,Guillou, Catherine
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p. 2043 - 2046
(2007/10/03)
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- ENANTIOSELECTIVE PREPARATION OF KEY INTERMEDIATES FOR STEROID SYNTHESIS THROUGH THE ASYMMETRIC MICHAEL ADDITION PROCESS INVOLVING CHIRAL IMINES.
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(S)-Phenanthrone 7, prepared from ketone 4 (80 percent yield, 93 percent ee), was transformed into compounds 8, 9, 13, 15 and 16, useful intermediates in steroid synthesis.
- d'Angelo, Jean,Revial, Gilbert,Volpe, Tony,Pfau, Michel
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p. 4427 - 4430
(2007/10/02)
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- Syntheses of 5-, 7-, and 8-Methoxy-3-methyl-2-tetralone
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Two efficient syntheses of 5-methoxy- and 8-methoxy-3-methyl-2-tetralone and the synthesis of the 7-methoxy isomer via a different route are described.Also reported is the synthesis of 8-methoxy-3,3-dimethyl-2-tetralone.The regioselectivity of lithium carbanion formation in 1,6-, 1,7-, and 2,7-dihydroxynaphthalene is discussed.The latter compound undergoes dimetalation more easily than the other isomers.
- Johansson, Anette M.,Mellin, Charlotta,Hacksell, Uli
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p. 5252 - 5258
(2007/10/02)
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- Benzobicycloalkane ketones
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Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.
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- Benzobicycloalkanone oximes
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Benzobicycloalkanone oximes which are intermediates for the preparation of benzobicycloalkane amines. The amines exert analgesic and antiinflammatory effects in warm-blooded animals.
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