431980-38-0

Basic information

• Product Name: RN-18
• Synonyms: RN-18
• CAS NO: 431980-38-0
• Molecular Formula: C₂₀H₁₆N₂O₄S
• Molecular Weight: 380.41704
• Mol File: 431980-38-0.mol

Chemical Properties

• Boiling Point: 493.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 12.33±0.70(Predicted)
• CAS DataBase Reference: RN-18(CAS DataBase Reference)
• NIST Chemistry Reference: RN-18(431980-38-0)
• EPA Substance Registry System: RN-18(431980-38-0)

Safety Data

• Hazardous Substances Data: 431980-38-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
RN-18 is used as an antiviral agent for the inhibition of HIV-1 replication. By selectively targeting the Vif-APOBEC interactions, RN-18 can potentially reduce the infectivity of the virus and help in the development of new therapeutic strategies against HIV-1.
Additionally, if there are other industries where RN-18 is used, they can be listed as follows:
Used in Research and Development:
RN-18 is used as a research tool for studying the mechanisms of HIV-1 replication and the role of Vif-APOBEC interactions in the virus life cycle. This can help researchers gain a better understanding of the virus and contribute to the development of novel antiviral therapies.
Used in Drug Discovery:
RN-18 serves as a lead compound in the search for new drugs targeting HIV-1. Its selective inhibition of Vif-APOBEC interactions can be a starting point for the design and synthesis of more potent and specific inhibitors, potentially leading to the development of new anti-HIV drugs.

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Relevant articles and documents

Synthesis and structure-activity relationship studies of hiv-1 virion infectivity factor (vif) inhibitors that block viral replication

The human immunodeficiency virus1 (HIV-1) virion infectivity factor (Vif) protein, essential for in vivo viral replication, protects the virus from innate antiviral cellular factor apolipoproteinB mRNA-editing, enzyme-catalytic, polypeptide-like3G (APOBEC

SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor

We describe structure-activity relationship and optimization studies of RN-18, an HIV-1 Vif-APOBEC3G axis inhibitor. Targeted modifications of RN-18 ring C, ring B, ring A, bridge A-B, and bridge B-C were performed to identify the crucial structural features, which generated new inhibitors with similar (4g and 4i) and improved (5, 8b, and 11) activities. Two potent water-soluble RN-18 analogues, 17 and 19, are also disclosed, and we describe the results of pharmacological studies with compound 19. The findings described here will be useful in the development of more potent Vif inhibitors and in the design of probes to identify the target protein of RN-18 and its analogues.

Composition and synthesis of new reagents for inhibition of HIV replication

The present invention provides compounds and compositions for inhibiting Vif and methods for treating viral infection, e.g., HIV infection.