452-14-2

Basic information

• Product Name: 3-FLUORO-4-METHOXYPHENYLACETIC ACID
• Synonyms: 3-FLUORO-4-METHOXYPHENYLACETIC ACID;RARECHEM AL BO 1534;3-Fluoro-4-methyloxyphenylaceticacid;3-Fluoro-4-methoxyphenylacetic acid 98%;3-Fluoro-4-methoxyphenylaceticacid98%;2-(3-fluoro-4-methoxyphenyl)acetic acid;4-(3-Fluoro-4-Methyloxyphenylacetic acid;4-(Carboxymethyl)-2-fluoroanisole
• CAS NO: 452-14-2
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.16
• EINECS: 224-854-0
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Fluorine series
• Mol File: 452-14-2.mol

Chemical Properties

• Melting Point: 111-113°C
• Boiling Point: 309 °C at 760 mmHg
• Flash Point: 140.7 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.000284mmHg at 25°C
• Storage Temp.: Store below +30°C.
• PKA: 4.25±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-METHOXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHOXYPHENYLACETIC ACID(452-14-2)
• EPA Substance Registry System: 3-FLUORO-4-METHOXYPHENYLACETIC ACID(452-14-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 452-14-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methoxyphenylacetic acid is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be modified into different derivatives, contributing to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluoro-4-methoxyphenylacetic acid serves as a key intermediate in the production of agrochemicals, such as pesticides and herbicides, due to its potential to be tailored into compounds with targeted biological activities for crop protection.
Used in Organic Chemistry Research:
3-Fluoro-4-methoxyphenylacetic acid is utilized as a valuable building block in organic chemistry research for its versatility in being modified into a range of derivatives, enabling the exploration of novel chemical reactions and the synthesis of new organic compounds with potential applications in various fields.

InChI:InChI=1/C9H9FO3/c1-13-8-3-2-6(4-7(8)10)5-9(11)12/h2-4H,5H2,1H3,(H,11,12)/p-1

Upstream product

• 345-72-2 ethyl 3-fluoro-4-methoxy-α-oxobenzeneacetate 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 404-90-0 2-(3-fluoro-4-methoxyphenyl)acetonitrile 

Downstream Products

• 1259307-80-6 3-[(3-fluoro-4-methoxyphenyl)acetyl]-9-methyl-3,9-diazaspiro[5.5]undecane trifluoroacetic acid salt 
• 404-91-1 2-(3-fluoro-4-methoxyphenyl)ethan-1-ol 
• 1265773-90-7 2-[6-(3-fluoro-4-methoxybenzyl)-1,2,3,7-tetrahydro-4H-indolo[2,3-c][1,8]naphthyridin-4-yl]acetamide 
• 1265774-76-2 4-(3-chloropropyl)-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-amine 
• 1265773-80-5 6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c][1,8]naphthyridine 
• 1265774-47-7 3-[3-amino-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-4-yl]propan-1-ol 
• 1265774-36-4 tert-butyl 3-(benzylamino)-4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carboline-9-carboxylate 
• 1265774-33-1 tert-butyl 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-3-{[(trifluoromethyl)sulfonyl]oxy}-9H-β-carboline-9-carboxylate 
• 1265774-29-5 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-yl trifluoromethanesulfonate 
• 1265774-24-0 4-[3-(benzyloxy)propyl]-1-(3-fluoro-4-methoxybenzyl)-9H-β-carbolin-3-ol 
• 1207516-23-1 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline 
• 1207516-22-0 11-bromo-6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline 
• 1207516-21-9 11-fluoro-6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinoline 
• 1207516-28-6 ethyl 10-fluoro-6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridine-3-carboxylate 

Relevant articles and documents

Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors

A series of 4-(2-fluorophenoxy)quinoline derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and five cancer cell lines (A549, H460, HT-29, MKN-45, and U87MG). Most compounds showed weak to excellent antiproliferative activity. The most promising analog, 40 (c-Met IC50 Combining double low line 1.86 nM), displayed 1.3-, 6.8-, 1.5-, 3.5-fold increase against HT-29, H460, A549 and U87MG cell lines, respectively, compared with Foretinib. An analysis of structure-activity relationships revealed that an acylhydrazone scaffold with an unsubstituted sp2 hybridized carbon adjacent to the 4-CF3 phenyl ring is favorable for antitumor activity.

USE OF QSAR IN DESIGN OF ANTIINFLAMMATORY FLUORINATED ARYLALKANOIC ACIDS

A series of 3-fluoro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated.The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected.Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations.Good coincidence was found out, as well as similarity of the regression equations derived for the originalseries of acids extended by the acids III.Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.