474709-71-2Relevant articles and documents
Highly selective electroreductive linear dimerization of electron-deficient vinylarenes
Ning, Shulin,Zheng, Lianyou,Bai, Ya,Wang, Shutao,Wang, Siyu,Shi, Lingling,Gao, Qiansong,Che, Xin,Zhang, Zhuoqi,Xiang, Jinbao
supporting information, (2021/11/16)
A direct electroreductive dimerization of electron-deficient vinylarenes for the synthesis of 1,4-diarylbutane has been developed using a simple undivided cell with inexpensive carbon electrodes at room temperature. The control and deuterium-labeling experiments of electroreductive dimerization suggest that the hydrogen source comes from the solvent CH3CN. This protocol provides a mild and efficient route for the construction of C–C bond in moderate to good yields with high regioselectivity and broad substrate scope.
Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine
Yu, Gang,Chen, Shunhong,He, Feng,Luo, Dexia,Zhang, Yu,Wu, Jian
, p. 1075 - 1085 (2019/09/10)
A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.
Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety
Xu,Wang,Luo,Yu,Guo,Fu,Zhao,Wu
, p. 6306 - 6314 (2018/02/19)
A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds E18 and E27 showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, respectively, which were close to that of avermectin (29.6 mg L-1); compounds E5, E6, E9, E10, E15, E25, E26, and E27 showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.
Discovery of Highly Potent Liver X Receptor β Agonists
Kick, Ellen K.,Busch, Brett B.,Martin, Richard,Stevens, William C.,Bollu, Venkataiah,Xie, Yinong,Boren, Brant C.,Nyman, Michael C.,Nanao, Max H.,Nguyen, Lam,Plonowski, Artur,Schulman, Ira G.,Yan, Grace,Zhang, Huiping,Hou, Xiaoping,Valente, Meriah N.,Narayanan, Rangaraj,Behnia, Kamelia,Rodrigues, A. David,Brock, Barry,Smalley, James,Cantor, Glenn H.,Lupisella, John,Sleph, Paul,Grimm, Denise,Ostrowski, Jacek,Wexler, Ruth R.,Kirchgessner, Todd,Mohan, Raju
supporting information, p. 1207 - 1212 (2016/12/18)
Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. The ag
2-Substituted-oxy-5-methylsulfonyl pyridine piperazine acidamide analogue and preparation method and application thereof
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Paragraph 0176; 0177, (2016/10/08)
The invention discloses 2-substituted-oxy-5-methylsulfonyl pyridine piperazine acidamide analogue and a preparation method and application thereof, and particularly, relates to 2-substituted-oxy-5-methylsulfonyl pyridine piperazine acidamide analogue with
HETEROCYCLIC COMPOUND
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Paragraph 0880, (2015/04/15)
The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
Pesticidal compositions and processes related thereto
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Page/Page column 53; 54, (2016/01/09)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Paragraph 0258; 0259; 0265; 0266, (2015/12/30)
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Page/Page column 53; 54, (2014/07/08)
This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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Paragraph 0244-0245, (2014/06/25)
This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.