Ethyl 4-BroMo-2-fluorobenzoate

Base Information

• Chemical Name: Ethyl 4-BroMo-2-fluorobenzoate
• CAS No.: 474709-71-2
• Molecular Formula: C9H8BrFO2
• Molecular Weight: 247.064
• Hs Code.: 2916399090
• Mol file: 474709-71-2.mol

Synonyms:ethyl 4-bromo-2-fluoro-benzoate;4-bromo-2-fluorophenyl ethyl carbonate;

Chemical Property of Ethyl 4-BroMo-2-fluorobenzoate

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 287.815oC at 760 mmHg
• Flash Point: 127.866oC
• PSA: 26.30000
• Density: 1.504g/cm3
• LogP: 2.76490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

Ethyl 4-bromo-2-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-BroMo-2-fluorobenzoate

There total 2 articles about Ethyl 4-BroMo-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethanol (64-17-5) + 2-fluoro-4-bromobenzoic acid (112704-79-7) → 4-bromo-2-fluorobenzoic acid ethyl ester (474709-71-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h;

Reference yield: 79.0%

→ 4-bromo-2-fluorobenzoic acid ethyl ester (474709-71-2)

Guidance literature:

Reference yield: 77.0%

4-bromo-2-fluorobenzoic acid ethyl ester (474709-71-2) + potassium vinyltrifluoroborate → Ethyl 2-fluoro-4-vinylbenzoate (1416979-62-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In tetrahydrofuran; water; at 85 ℃; for 22h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tet.2021.132535

upstream raw materials:

ethanol

2-fluoro-4-bromobenzoic acid

Downstream raw materials:

4-bromo-2-fluorobenzohydrazide

ethyl 2-fluoro-4-(2-nitrophenylamino)benzoate

ethyl 4-bromo-2-ethoxybenzoate

3-(4-bromo-2-fluorophenyl)-3-oxopropanenitrile