479-83-4

Basic information

• Product Name: 4',6-Dihydroxy-5,7-dimethoxyisoflavone
• Synonyms: 4',6-Dihydroxy-5,7-dimethoxyisoflavone;Muningin
• CAS NO: 479-83-4
• Molecular Formula: C₁₇H₁₄O₆
• Molecular Weight: 314.2895
• Mol File: 479-83-4.mol

Chemical Properties

• Boiling Point: 586.8°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.402g/cm³
• Vapor Pressure: 2.29E-14mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 4',6-Dihydroxy-5,7-dimethoxyisoflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 4',6-Dihydroxy-5,7-dimethoxyisoflavone(479-83-4)
• EPA Substance Registry System: 4',6-Dihydroxy-5,7-dimethoxyisoflavone(479-83-4)

Safety Data

• Hazardous Substances Data: 479-83-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H14O6/c1-21-13-7-12-14(17(22-2)16(13)20)15(19)11(8-23-12)9-3-5-10(18)6-4-9/h3-8,18,20H,1-2H3

Upstream product

• 114330-55-1 6-acetoxy-3-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 121816-57-7 6-benzyloxy-3-(4-benzyloxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 1026471-07-7 1-(3,6-Dihydroxy-2,4-dimethoxy-phenyl)-2-(4-hydroxy-phenyl)-3,3-dimethoxy-propan-1-one 
• 6962-57-8 3,6-dihydroxy-2,4-dimethoxyacetophenone 
• 175988-38-2 1-(3,6-Bis-benzyloxy-2,4-dimethoxy-phenyl)-ethanone 
• 175988-40-6 (E)-3-(4-Benzyloxy-phenyl)-1-(3,6-bis-benzyloxy-2,4-dimethoxy-phenyl)-propenone 
• 22110-04-9 6-hydroxy-2,3,4-trimethoxyphenyl p-methoxybenzyl ketone 
• 13539-26-9 6-Hydroxygenistein 
• 4332-73-4 4',5,6,7-tetramethoxyisoflavone 
• 175988-51-9 6-acetoxy-3-(4-acetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 

Downstream Products

• 135010-75-2 7-methoxy-5,6,4'-trihydroxyisoflavone 
• 114330-55-1 6-acetoxy-3-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 175988-51-9 6-acetoxy-3-(4-acetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 
• 13539-26-9 6-Hydroxygenistein 

Relevant articles and documents

Studies of the selective O-alkylation and dealkylation of flavonoids. XX. A convenient method for synthesizing 5,6,7-trihydroxyisoflavones and 5,6-dihydroxy-7-methoxyisoflavones

3′,6′-Bis(benzyloxy)-2′,4′-dimethoxychalcones, which were derived from dibenzyl ether of 3,6-dihydroxy-2,4-dimethoxyacetophenone, were oxidatively rearranged with thallium(III) nitrate (TTN) in methanol to give 2-aryl-1-[3,6-bis(benzyloxy)-2,4-dimethoxyphenyl]-3,3-dimethoxypropan-1-ones; these products were converted into 6-hydroxy-5,7-dimethoxyisoflavones by hydrogenolysis followed by cyclization. The 5-methoxy group in the acetates of the isoflavones was selectively cleaved with 5% (w/v) anhydrous aluminum bromide in acetonitrile to give quantitatively the corresponding 5-hydroxyisoflavones, which were hydrolyzed to 5,6-dihydroxy-7-methoxyisoflavones. The acetates were also demethylated to 5,6,7-trihydroxyisoflavones with 30% (w/v) anhydrous aluminum chloride in acetonitrile at 70 °C for 36-48 h. The spectral properties of these isoflavones were examined and some natural isoflavones were identified.