- On the Stereochemistry of 2,6-Dichloro-4-methoxy-heptanes
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2,6-Dichloro-4-methoxy-heptanes may exist as 2 optical active isomers and 2 meso compounds.By double addition of α,α-dichloro-dimethylether to propene a mixture of these stereoisomers was obtained.They were separated by HPLC.Using 1H- and 13C-NMR-spectroscopy their configuration could be established. - Keywords: 2,6-Dichloro-4-methoxy-heptanes; Stereoisomers; NMR-Spectroscopy; Configurational assignment
- Meusinger, Reinhard,Duschek, Christian,Kleinpeter, Erich,Borsdorf, Rolf,Pihlaja, Kalevi,Mattinen, Jorma
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- Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers
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Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.
- Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu
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p. 587 - 593
(2019/07/22)
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- Convenient preparation of dichloromethyl alkyl ethers
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Dichloromethyl alkyl ethers have been synthesized from alkyl formates (C1–C4) and oxalyl chloride in the presence of catalytic amount of N-methylformanilide. N,N-Dimethylformamide is not suitable for the reaction. The method has the advantages of simple experimental procedure, which is applicable to large scale synthesis, without use of harmful reagents.
- Kimura, Yoshikazu,Warashina, Takuya
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p. 4598 - 4599
(2017/11/15)
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- METHOD FOR MANUFACTURING DICHLOROMETHYL ALKYL ETHER COMPOUND
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PROBLEM TO BE SOLVED: To provide a method for manufacturing a dichloromethyl alkylether compound safe, easy to handle and less effect on environment. SOLUTION: There is provided a method for manufacturing a dichloromethyl alkylether compound represented by the general formula [3] by reacting a formic acid ester compound represented by the general formula [2] and a chloride compound represented by the general formula [P] in a presence of a formanilide compound represented by the general formula [1]. In the formulae [1], [2], [3], [P], X represents a methyl group or a phenyl group which may have a substituent, R' represents a lower alkyl group or a halogen atom, m represents an integer of 0 to 5, R represents an alkyl group having 1 to 6 carbon atoms, and n represents 1 or 2. COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0038
(2016/10/07)
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- Process for the preparation of methyl 1,1-dichloromethyl ether or of ethyl 1,1-dichloromethyl ether
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The invention relates to a process for the preparation of methyl 1,1-dichloromethyl ether or of ethyl 1,1-dichloromethyl ether, according to which methyl formate or ethyl formate is reacted with phosgene, diphosgene, triphosgene or oxalyl chloride or one of their mixtures, at a temperature of between 40° C. and 100° C., in the presence of a catalyst chosen from the group consisting of trisubstituted phosphine oxides and sulphides, trisubstituted phosphine dichlorides, formamides, the products of reaction of formamides with chlorinating agents and mixtures thereof. The 1,1-dichloromethyl ethers are obtained in a high purity. They are useful especially for performing the formylation of aromatic compounds.
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- Synthesis of p-Alkyl-, p-Alkoxy-, and p-Acyloxycinnamates with trans-4-Phenylcyclohexyl and 4-Biphenylyl Fragments and Their Mesomorphic Properties
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Acylation of trans-4-phenylcyclohexanol and p-cyano-p'-hydroxybiphenyl with p-n-alkyl-, p-n-alkoxy-, and p-n-alkanoyloxycinnamoyl chlorides yields corresponding cinnamates.
- Bykova, V. V.,Zharova, M. A.,Maidachenko, G. G.
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p. 1143 - 1145
(2007/10/03)
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- Chemotherapeutic agents
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A method of treating or preventing viral infections, in particular rhinovirus infections comprising the administration of an effective amount of a 2-phenyltetralin derivative or a heterocyclic analogue thereof. Pharmaceutical compositions containing these compounds, and some novel compounds are also disclosed.
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- Methoxychlorocarbene. Matrix Spectroscopy and Photochemistry
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Irradiation of 3-chloro-3-methoxydiazirine matrix isolated in argon or nitrogen at 10 K gives methoxychlorocarbene.The carbene was observed by IR and UV spectroscopy.Deuterium and 18O labeling indicated significant C-O double bond character in the carbene, which was exhibited in an intense IR absorption at ca. 1300 cm-1.The time evolution and wavelength dependence of the IR bands indicate two geometric isomers for the carbene, with distinct IR absorptions.The cis-carbene shows a significantly lower energy C-Cl stretch than the trans, consistent with an anomeric interaction.Irradiation of the carbene gives acetyl chloride, ketene, and HCl in argon matrices.In nitrogen, small amounts of CO and methylchloride are also observed.Several mechanisms are proposed to explain the photochemical results.
- Kesselmayer, Mark A.,Sheridan, Robert S.
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