- TRI- AND TETRAOXYGENATED XANTHONES FROM SWERTIA PETIOLATA
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A new tetra-oxygenated xanthone glycoside: 1-glucosyloxy-3-hydroxy-5,8-dimethoxyxanthone has been isolated and identified from the methanolic extract of the aerial parts of Sweria petiolata along with 1,8-dihydroxy-3,5-dimethoxyxanthone; 1,3-dihydroxy-7-methoxyxanthone and 1,7-dihydroxy-3-methoxyxanthone
- Khetwal, Khadga S.,Joshi, Binita,Bisht, R. S.
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- A XANTHONE FROM SWERTIA CHIRAYITA
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The structure of new xanthone from Swertia chirayita has been established as 1,5-dihydroxy-3,8-dimethoxy xanthone (chiratol) on the basis of spectral and chemical evidence.Two other xanthones, i. e. swerchirin (1,8-dihydroxy-3,5-dimethoxy xanthone) and 7-O-methyl swertianin (1,8-dihydroxy-3,7-dimethoxy xanthone) have been isolated.Swerchirin was identified as the hypoglycaemic principle of the plant.
- Asthana, Rakesh K.,Sharma, Narendra K.,Kulshreshtha, Dinesh K.,Chatterjee, Sunil K.
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- Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity
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Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC 50 values in the range 126 to 451 μM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 μM).
- Wan, Luo-Sheng,Min, Qiu-Xia,Wang, Yong-Long,Yue, Yao-Dong,Chen, Jia-Chun
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p. 1248 - 1253
(2013/08/23)
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