2798-25-6

Usage

Uses

Used in Pharmaceutical Applications:
Bellidifolin is used as a hepatoprotective agent for its notable protective effects against carbon tetrachloride (CCl4)-induced HepG2 cell damage. It helps in alleviating the levels of aspartate transaminase (AST), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and malonic dialdehyde, thereby supporting liver health and functioning.
Used in Traditional Medicine:
Bellidifolin is also utilized in traditional medicine, particularly in the Swertia genus, for its various therapeutic properties. As a chemotaxonomic marker, it aids in the identification and classification of plant species within the Swertia genus, which are known for their medicinal values.

InChI:InChI=1/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3

Upstream product

• 23445-00-3 swertianolin 
• 108-73-6 3,5-dihydroxyphenol 
• 303-07-1 2,6-Dihydroxybenzoic acid 
• 2980-32-7 1,3,5,8-tetrahydroxyxanthone 
• 74-88-4 methyl iodide 

Downstream Products

• 2980-32-7 1,3,5,8-tetrahydroxyxanthone 
• 5557-27-7 1,3,5-Trimethoxy-8-hydroxyxanthone 
• 49599-09-9 1,8-dihydroxy-3,5,8-trimethoxyxanthone 

Relevant academic research and scientific papers

A bellidifodin preparing method

A bellidifodin preparing method is disclosed. The method includes preparing methanesulfonic acid and phosphorus pentoxide according to a ratio into a composite medium, adding 2,6-dihydroxybenzoic acid and phloroglucinol into the medium, performing a reaction to obtain 1,3,8-trihydroxy xanthenone, performing selective oxidation under alkaline conditions through using potassium persulfate to obtain 1,3,5,8-tetrahydroxy xanthenone, and subjecting the 1,3,5,8-tetrahydroxy xanthenone and iodomethane to methylation to obtain the target compound that is the bellidifodin. According to the method, reaction steps are shortened, reaction operation is simplified, the yield is increased and the method has certain application value.

XANTHONE AND FLAVONOL CONSTITUENTS OF SWERTIA HOOKERI

The whole plant of Swertia hookeri, collected at flowering has been shown to contain two tri- and nine tetraoxygenated free, glucosyloxy, and stearyl ester xanthones and one flavonol stearyl ester.Among these, three are previously unreported in nature and one was known previously only as a synthetic compound.The xanthones are based on 1,3,5-, 1,3,5,8- and 1,3,7,8-oxygenated systems with the middle oxygenation pattern predominating.The two ester compounds appeared only at the flowering stage.Plants collected at the pre-flowering stage gave the corresponding free compounds.The biochemical and biological significance of these findings are appraised.Key Word Index - Swertia hookeri; Gentianaceae; 1-O-stearyl-3,5-dimethoxyxanthone; 3-O-stearyl-3',4',5,7-tetra-O-methylquercetin; 1-hydroxy-3,5-dimethoxyxanthone; tetraoxygenated xanthones; 8-O-β-D-glucosyl-1,3-dihydroxy-5-methoxyxanthones; 8-O-β-D-glucosyl-1,5-dihydroxy-3-methoxyxanthone.

A New Xanthone Glycoside from Swertia angustifolia Buch-Ham ex. D. Don

The structure of a new xanthone glycoside isolated from the whole plant of Swertia angustifolia Buch-Ham ex.D.Don has been established as 1,5-dihydroxy-3-methoxyxanthone-8-O-β-D-glucoside (I) on the basis of spectral data (IR, UV, PMR) and chemical studies.