Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells
Caspase-3/8 are key members of the cysteine-aspartyl protease family with pivotal roles in apoptosis. We have designed and synthesized self-assembling probes, Nap-GFFpYDEVD-AFC and Nap-GFFpYIETD-AFC, with fluorescence 'turn-on' properties for real-time mo
Self-assembling peptide-etoposide nanofibers for overcoming multidrug resistance
We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug. This journal is
QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF
Compounds and methods for their preparation and use as therapeutic or prophylactic agents, fo example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1).
-
Paragraph 00247-00248
(2020/10/09)
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
We report the characterization and optimization of drug-like smallmolecule inhibitors of tissue-nonspecific alkaline phosphatase (TNAP), an enzyme critical for the regulation of extracellular matrix calcification during bone formation and growth.High-thro
Dahl, Russell,Sergienko, Eduard A.,Su, Ying,Mostofi, Yalda S.,Yang, Li,Simao, Ana Maria,Narisawa, Sonoko,Brown, Brock,Mangravita-Novo, Arianna,Vicchiarelli, Michael,Smith, Layton H.,O'Neill, W. Charles,Millán, José Luis,Cosford, Nicholas D. P.
experimental part
p. 6919 - 6925
(2010/04/24)
More Articles about upstream products of 496014-13-2