49631-88-1

Basic information

• Product Name: N-acetyl-1,6-diaminohexane
• Synonyms: N-acetyl-1,6-diaminohexane
• CAS NO: 49631-88-1
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.24
• Mol File: 49631-88-1.mol

Chemical Properties

• Boiling Point: 324.7°Cat760mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 0.929g/cm³
• Vapor Pressure: 0.000241mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: N-acetyl-1,6-diaminohexane(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-1,6-diaminohexane(49631-88-1)
• EPA Substance Registry System: N-acetyl-1,6-diaminohexane(49631-88-1)

Safety Data

• Hazardous Substances Data: 49631-88-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H18N2O/c1-8(11)10-7-5-3-2-4-6-9/h2-7,9H2,1H3,(H,10,11)

Upstream product

• 60-35-5 acetamide 
• 124-09-4 1,6-Hexanediamine 
• 75-05-8 acetonitrile 

Downstream Products

• 53671-77-5 N-[6-(2-Hydroxy-3-phenoxy-propylamino)-hexyl]-acetamide 
• 143-23-7 1,8,15-triazapentadecane 
• 1335025-26-7 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid 
• 124-09-4 1,6-Hexanediamine 

Relevant articles and documents

Amide exchange reaction: A simple and efficient CuO catalyst for diacetamide synthesis

A highly copper-catalysed amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O for the synthesis of hexamethylenebisacetamide (HMBA) without an organic solvent or gas protection was developed. 100% HDA conversion and >99% HMBA selectivity was obtained. X-ray diffraction, scanning emission microscopy, and temperature-programmed reduction of hydrogen were used to characterize the structural properties of the catalyst. The reaction mechanism was also investigated.

A Simple and Economic Synthesis of Monoacylated Alkanediamines by Thermal Transamidation

N-(ω-Aminoalkyl)amides 2 are easily synthesized by heating mixtures of excess α,ω-alkanediamines 1 and primary amides to temperatures between 150 deg C and 200 deg C, at which thermal transamidation occurs.Under the reaction conditions ammonia is released, and 2 is in equilibrium with the alkanediamine 1 and the α,ω-bis(acylamino)alkane 3.Thus, thermal transamidation is a practicable way to overcome the problem of diacylation which appears as an often recognized problem even in the latest literature.