N-acetyl-1,6-diaminohexane

Base Information

• Chemical Name: N-acetyl-1,6-diaminohexane
• CAS No.: 49631-88-1
• Molecular Formula: C8H18 N2 O
• Molecular Weight: 158.244
• Mol file: 49631-88-1.mol

Synonyms:6-Acetamidohexylamine;N-(6-Aminohexyl)acetamide; N-Acetyl-1,6-diaminohexane;N-Acetyl-1,6-hexanediamine

Chemical Property of N-acetyl-1,6-diaminohexane

Chemical Property:

• Vapor Pressure: 0.000241mmHg at 25°C
• Boiling Point: 324.7°Cat760mmHg
• Flash Point: 150.2°C
• PSA: 58.61000
• Density: 0.929g/cm³
• LogP: 2.18220

Purity/Quality:

99% ^*data from raw suppliers

HEXA METHYLENDIAMINE MONOACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-acetyl-1,6-diaminohexane

There total 2 articles about N-acetyl-1,6-diaminohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

acetamide (60-35-5) + 1,6-Hexanediamine (124-09-4) → mono-N-acetylhexamethylenediamine (49631-88-1) + hexamethylene bisacetamide (3073-59-4)

Guidance literature:

for 10h; Heating;

Reference yield:

1,6-Hexanediamine (124-09-4) + acetonitrile (75-05-8,26809-02-9) → mono-N-acetylhexamethylenediamine (49631-88-1) + hexamethylene bisacetamide (3073-59-4)

Guidance literature:

With water; copper; at 180 ℃; for 2h; Reagent/catalyst;

DOI:10.1039/c6ra05563j

Reference yield: 56.0%

mono-N-acetylhexamethylenediamine (49631-88-1) + 6-chloro-2-chloromethyl-4-phenylquinoline-3-carboxylic acid ethyl ester (126334-85-8) → 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid (1335025-26-7)

Guidance literature:

mono-N-acetylhexamethylenediamine; 6-chloro-2-chloromethyl-4-phenylquinoline-3-carboxylic acid ethyl ester; With potassium carbonate; for 0.125h; Microwave irradiation;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1016/j.ejmech.2011.05.035

upstream raw materials:

acetamide

1,6-Hexanediamine

acetonitrile

Downstream raw materials:

N-[6-(2-Hydroxy-3-phenoxy-propylamino)-hexyl]-acetamide

1,8,15-triazapentadecane

2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid

1,6-Hexanediamine

Refernces

• 1、 Zaragoza-Doerwald, Florencio,Kiedrowski, Guenter von. "A Simple and Economic Synthesis of Monoacylated Alkanediamines by Thermal Transamidation". . p. 917 - 918. Retrieved 2007/10/02.